Patents by Inventor Dennis E. Kyle

Dennis E. Kyle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemosensitizing agents against chloroquine resistant plasmodium falciparum and methods of making and using thereof
    Publication number: 20030032801
    Abstract: A compound having the structural formula 1
    Type: Application
    Filed: May 7, 2001
    Publication date: February 13, 2003
    Inventors: Ai J. Lin, Jian Guan, Dennis E. Kyle, Wilbur K. Milhous
  • Indolo[2,1-b] quinazole-6,12-dione antimalarial compounds and methods of treating malaria therewith
    Publication number: 20010034350
    Abstract: Compounds, compositions and methods are provided for treating malaria parasites in vitro and in vivo by administering indolo[2,1-b]quinazoline-6,12-dione compounds of Formula I.
    Type: Application
    Filed: May 8, 2001
    Publication date: October 25, 2001
    Inventors: Kevin K. Pitzer, John P. Scovill, Dennis E. Kyle, Lucia Gerena
  • Indolo[2,1-B] quinazole-6,12-dione antimalarial compounds and methods of treating malaria therewith
    Patent number: 6284772
    Abstract: Compounds, compositions and methods are provided for treating malaria parasites in vitro and in vivo by administering indolo[2,1-b]quinazoline-6,12-dione compounds of Formula I.
    Type: Grant
    Filed: September 28, 1999
    Date of Patent: September 4, 2001
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Kevin K. Pitzer, John P. Scovill, Dennis E. Kyle, Lucia Gerena
  • Method for the treatment of malaria
    Patent number: 5206236
    Abstract: A method for treating malaria which comprises to an afflicted host patient a therapeutically effective amount of a compound have the structure of formula I: ##STR1## wherein X is O or NH; R.sub.1 is H or two R.sub.1 groups on the same amidine group together represents --(CH.sub.2).sub.m --, wherein m=2, 3 or 4; R.sub.2 is H, NH.sub.2, Cl, NO.sub.2 ; R.sub.3 is H, CH.sub.3 or CH.sub.2 CH.sub.3 and n=2-6 or a pharmaceutically acceptable salt thereof provided that when X is O, both R.sub.2 and both R.sub.3 can not be H.
    Type: Grant
    Filed: September 5, 1991
    Date of Patent: April 27, 1993
    Inventors: Richard R. Tidwell, J. Dieter Geratz, James E. Hall, Dennis E. Kyle, Max Grogl, Kwasi A. Ohemeng
  • Method for treating leishmaniasis
    Patent number: 5202320
    Abstract: This invention relates to a method for treating leishmaniasis which comprises administering to an afflicted host patient, a therapeutically effective amount of a compound having the following structure; ##STR1## wherein X is O or NH; R.sub.1 is H or two R.sub.1 of the same amidine group together represent --(CH.sub.2).sub.m -- wherein m=2, 3 or 4; R.sub.2 is H, NH.sub.2, OCH.sub.3, Cl or NO.sub.2 ; R.sub.3 is H, CH.sub.3 or CH.sub.2 CH.sub.3 and n=2-6 or a pharmaceutical acceptable salt thereof provided that X is O both R.sub.2 and both R.sub.3 cannot be H.
    Type: Grant
    Filed: April 6, 1989
    Date of Patent: April 13, 1993
    Inventors: Richard R. Tidwell, J. Dieter Geratz, James E. Hall, Dennis E. Kyle, Max Grogl, Kwasi A. Ohemeng