Patents by Inventor Dennis Eshima
Dennis Eshima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11904289Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutiType: GrantFiled: December 22, 2020Date of Patent: February 20, 2024Assignee: Cardinal Health 414, LLCInventors: Dennis Eshima, Mehmet Husnu, James Stone, Derrick Alcaide, Joseph E. Zambanini, Thomas A. Klausing, Chad E. Bouton, Henry Padgett, Brian C. Kelley, Scott N. Danhof, David A. Holley, Jeffrey T. Stroup, James B. Gleeson, Eric Hassenpflug, James A. Prescott, Herman Benecke, Daniel B. Garbark
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Publication number: 20210187467Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutiType: ApplicationFiled: December 22, 2020Publication date: June 24, 2021Inventors: Dennis ESHIMA, Mehmet HUSNU, James STONE, Derrick ALCAIDE, Joseph E. ZAMBANINI, Thomas A. KLAUSING, Chad E. BOUTON, Henry PADGETT, Brian C. KELLEY, Scott N. DANHOF, David A. HOLLEY, Jeffrey T. STROUP, James B. GLEESON, Eric HASSENPFLUG, James A. PRESCOTT, Herman BENECKE, Daniel B. GARBARK
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Patent number: 10906020Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutiType: GrantFiled: September 30, 2015Date of Patent: February 2, 2021Assignee: CARDINAL HEALTH 414, LLCInventors: Dennis Eshima, Mehmet Husnu, James Stone, Derrick Alcaide, Joseph E. Zambanini, Thomas A. Klausing, Chad E. Bouton, Henry Padgett, Brian C. Kelley, Scott N. Danhof, David A. Holley, Jeffrey T. Stroup, James B. Gleeson, Eric Hassenpflug, James A. Prescott, Herman Benecke, Daniel B. Garbark
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Patent number: 10226401Abstract: A closed path vial fill system includes a bulk product vial, a peristaltic pump operated by a stepper motor, a dispensing manifold assembly to which may be coupled at least one final product vial, an optional quality check station, and an optional waste collection system. A concentration, activity, and volume (CAV) sensor may be incorporated into the system to receive a radiopharmaceutical product directly from a synthesizing unit. A control system may be integrated into the system to provide automated control of various aspects of the radiopharmaceutical dispensing process. The system is used to aseptically dispense finished radiopharmaceuticals into receiving vessels, such as a Quality Control vial, a sterility vial, and/or final product vials, while providing users an efficient means for removing and discarding contaminated disposable components.Type: GrantFiled: August 10, 2015Date of Patent: March 12, 2019Assignee: Cardinal Health 414, LLCInventors: Mehmet Husnu, Dennis Eshima, Derrick Michael Alcaide, Scott Nicholas Danhof, James B. Gleeson, Eric Gustin Hassenpflug, James Alan Prescott
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Patent number: 9480962Abstract: Compact modular cassette systems and methods for the synthesis of radiopharmaceutical products are provided, the compact modular cassette system including a modular unit having valve plates, a reaction cassette, a reagent pack, and other seal and connector plates to ensure that reagents can be mixed together inside one or more chambers of the reaction cassette in a timely and efficient manner. When a new chamber for each new reaction or process should be used, a valveless modular system having removable reaction cassettes and the reagent packs may be used. In such a system, the reagent container, the reaction cassette, or both, can be removed from the modular cassette system and discarded after a desired reaction or process has taken place.Type: GrantFiled: March 2, 2015Date of Patent: November 1, 2016Assignee: Cardinal Health 414, LLCInventors: Thomas Alan Klausing, Brian Charles Kelley, Joseph Edward Zambanini, David Arthur Holley, Jeffrey Taylor Stroup, Mehmet Husnu, Dennis Eshima
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Publication number: 20160263545Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutiType: ApplicationFiled: September 30, 2015Publication date: September 15, 2016Applicant: CARDINAL HEALTH 414, LLCInventors: DENNIS ESHIMA, MEHMET HUSNU, JIM STONE, DERRICK ALCAIDE, JOSEPH E. ZAMBANINI, THOMAS A. KLAUSING, CHAD E. BOUTON, HENRY PADGETT, BRIAN C. KELLEY, SCOTT N. DANHOF, DAVID A. HOLLEY, JEFFREY T. STROUP, JAMES B. GLEESON, ERIC HASSENPFLUG, JAMES A. PRESCOTT, HERMAN BENECKE, DANIEL B. GARBARK
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Publication number: 20160199257Abstract: A closed path vial fill system includes a bulk product vial, a peristaltic pump operated by a stepper motor, a dispensing manifold assembly to which may be coupled at least one final product vial, an optional quality check station, and an optional waste collection system. A concentration, activity, and volume (CAV) sensor may be incorporated into the system to receive a radiopharmaceutical product directly from a synthesizing unit. A control system may be integrated into the system to provide automated control of various aspects of the radiopharmaceutical dispensing process. The system is used to aseptically dispense finished radiopharmaceuticals into receiving vessels, such as a Quality Control vial, a sterility vial, and/or final product vials, while providing users an efficient means for removing and discarding contaminated disposable components.Type: ApplicationFiled: August 10, 2015Publication date: July 14, 2016Applicant: CARDINAL HEALTH 414, LLCInventors: MEHMET HUSNU, DENNIS ESHIMA, DERRICK ALCAIDE, SCOTT N. DANHOF, JIM GLEESON, ERIC HASSENPFLUG, JIM PRESCOTT
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Patent number: 9139316Abstract: A closed path vial fill system includes a bulk product vial, a peristaltic pump operated by a stepper motor, a dispensing manifold assembly to which may be coupled at least one final product vial, an optional quality check station, and an optional waste collection system. A concentration, activity, and volume (CAV) sensor may be incorporated into the system to receive a radiopharmaceutical product directly from a synthesizing unit. A control system may be integrated into the system to provide automated control of various aspects of the radiopharmaceutical dispensing process. The system is used to aseptically dispense finished radiopharmaceuticals into receiving vessels, such as a Quality Control vial, a sterility vial, and/or final product vials, while providing users an efficient means for removing and discarding contaminated disposable components.Type: GrantFiled: December 28, 2011Date of Patent: September 22, 2015Assignee: Cardinal Health 414, LLCInventors: Mehmet Husnu, Dennis Eshima, Derrick Alcaide, Scott N. Danhof, Jim Gleeson, Eric Hassenpflug, Jim Prescott
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Publication number: 20130102772Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutiType: ApplicationFiled: July 16, 2012Publication date: April 25, 2013Applicant: CARDINAL HEALTH 414, LLCInventors: Dennis ESHIMA, Mehmet Husnu, Jim Stone, Derrick Alcaide, Henry Padgett, Joseph E. Zambanini, Thomas A. Klausing, Chad E. Bouton, Brian C. Kelley, Scott N. Danhof, David A. Holley, Jeffrey T. Stroup, James B. Gleeson, Eric Hassenpflug, James A. Prescott, Herman Benecke, Daniel B. Garbark
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Publication number: 20130060017Abstract: The invention relates to methods for synthesizing compounds on solid supports. The invention also relates to synthesizing labeled compounds, such as those used in the field of radiopharmaceuticals. The invention relates to methods for synthesizing halogenated radiopharmaceuticals such as fludeoxyglucose (also known as fluorodeoxyglucose or FDG).Type: ApplicationFiled: July 16, 2012Publication date: March 7, 2013Applicant: CARDINAL HEALTH 414, LLCInventors: Dennis ESHIMA, Mehmet HUSNU, Jim STONE, Brian C. KELLEY
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Publication number: 20130060134Abstract: A tumor treatment apparatus may include an array of collimated CZT detectors configured to intersect a known coordinate and measure gamma radiation activity, for example at 511 keV. A radiation delivery system may be configured to direct radiation through the known coordinate on the basis of the gamma radiation activity. A translatable and rotatable table may be configured to support a tumor host, wherein the tumor is positionable relative to the known coordinate on the basis of the gamma radiation activity emitted by the tumor and measured by the array of collimated CZT detectors. Radiation from the radiation delivery system may be delivered to the tumor at the known coordinate, and may be delivered in an intra-operative surgical environment.Type: ApplicationFiled: September 7, 2012Publication date: March 7, 2013Applicant: CARDINAL HEALTH 414, LLCInventors: Dennis ESHIMA, Mehmet HUSNU, Jim STONE
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Publication number: 20130018618Abstract: A method and system for performing automated quality control analysis of a plurality of radiopharmaceuticals are provided. The method includes uniquely identifying each of the plurality of radiopharmaceuticals, and identifying and implementing a tailored quality control program for each of the radiopharmaceuticals. The method further includes automatically performing a plurality of selected quality control tests for each of the radiopharmaceuticals based on the tailored quality control program, and collecting information produced by the plurality of selected quality control tests.Type: ApplicationFiled: July 16, 2012Publication date: January 17, 2013Applicant: CARDINAL HEALTH 414, LLCInventors: Dennis Eshima, Mehmet Husnu, Jim Stone
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Publication number: 20120222774Abstract: A closed path vial fill system includes a bulk product vial, a peristaltic pump operated by a stepper motor, a dispensing manifold assembly to which may be coupled at least one final product vial, an optional quality check station, and an optional waste collection system. A concentration, activity, and volume (CAV) sensor may be incorporated into the system to receive a radiopharmaceutical product directly from a synthesizing unit. A control system may be integrated into the system to provide automated control of various aspects of the radiopharmaceutical dispensing process. The system is used to aseptically dispense finished radiopharmaceuticals into receiving vessels, such as a Quality Control vial, a sterility vial, and/or final product vials, while providing users an efficient means for removing and discarding contaminated disposable components.Type: ApplicationFiled: December 28, 2011Publication date: September 6, 2012Applicant: CARDINAL HEALTH 414, LLCInventors: Mehmet HUSNU, Dennis Eshima, Derrick Alcaide, Scott N. Danhof, Jim Gleeson, Eric Hassenpflug, Jim Prescott
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Publication number: 20110029445Abstract: A computer includes a memory and a processor, the memory having instrul. A computer-implemented method, a computer comprising a storage device, a memory and a processor, the storage device having instructions stored therein. The instructions, which when executed by the processor, causes the computer to (1) receive, at the production module, a request for production of a radioactive pharmaceutical; (2) verify, utilizing a training module on the computer, completion by the user of at least a training program corresponding to production of the radioactive pharmaceutical; (3) verify completion by the user of equipment calibration requirements and equipment qualification requirements for the equipment that is used in the production of the radioactive pharmaceutical; and (4) prevent access to further operations of the production module if the training program has not been completed, the equipment calibration requirements have not been completed or the equipment qualification requirements have not been completed.Type: ApplicationFiled: July 30, 2010Publication date: February 3, 2011Applicant: BIODOSE, LLCInventors: Bretten Whittacre, Dennis Eshima, Arris Robinson, Troy Connelly
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Publication number: 20030194373Abstract: The present invention relates to compounds that are effective for targeting sites of angiogenesis for diagnostic and therapeutic purposes. The compounds are of the Formula (I) A-(B)n-C, wherein A is a chelator moiety capable of complexing a radionuclide metal or a moiety capable of binding to a halogen; B is a spacer group; C is an angiogenesis targeting molecule; and n is selected from the integers 0 and 1. The invention also relates to a method of imaging sites of angiogenesis and treating patients through the administration of the compounds of the present invention.Type: ApplicationFiled: April 22, 2003Publication date: October 16, 2003Inventors: Theresa Fauconnier, Alfred Pollak, John Thornback, Dennis Eshima
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Patent number: 6375927Abstract: Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance up-take of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body.Type: GrantFiled: February 17, 2000Date of Patent: April 23, 2002Inventors: Jerry L. Born, Dennis Eshima, Paul L. Mann, Nicholas A. Matwiyoff
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Patent number: 6033644Abstract: Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance uptake of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body.Type: GrantFiled: November 5, 1998Date of Patent: March 7, 2000Assignee: University of New MexicoInventors: Jerry L. Born, Dennis Eshima, Paul L. Mann, Nicholas A. Matwiyoff
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Patent number: 5906807Abstract: Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance uptake of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body.Type: GrantFiled: March 16, 1995Date of Patent: May 25, 1999Assignee: University of New MexicoInventors: Jerry L. Born, Dennis Eshima, Paul L. Mann, Nicholas A. Matwiyoff
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Patent number: 5401489Abstract: Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance uptake of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body.Type: GrantFiled: May 1, 1991Date of Patent: March 28, 1995Assignee: University of New MexicoInventors: Jerry L. Born, Dennis Eshima, Paul L. Mann, Nicholas A. Matwiyoff
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Patent number: 5399338Abstract: Biomodulators, in conjunction with antibodies, tumor-specific agents or conjugates thereof, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radioimages, preferably by increasing aberrant tissue signal intensity.Type: GrantFiled: May 1, 1991Date of Patent: March 21, 1995Assignee: University of New MexicoInventors: Jerry L. Born, Dennis Eshima, Paul L. Mann, Nicholas A. Matwiyoff, Buck A. Rhodes