Patents by Inventor Dennis Fordham

Dennis Fordham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of interferon-? purification and recovery
    Patent number: 8388942
    Abstract: Improved methods for purification and recovery of interferon-beta (IFN-?) and compositions comprising substantially monomeric IFN-? are provided. In one purification method, substantially purified IFN-? or variant thereof is precipitated and then dissolved in a guanidine hydrochloride (HCl) solution. Renaturation of the protein occurs by dilution with a suitable buffer. A similar purification method absent the precipitation step is also provided. Following renaturation of the IFN-?, residual guanidine HCl is removed by diafiltration or dialysis with a pharmaceutically acceptable buffer to prepare pharmaceutical compositions comprising substantially monomeric IFN-?.
    Type: Grant
    Filed: April 29, 2008
    Date of Patent: March 5, 2013
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Sidney N Wolfe, Bret A Shirley, Susan Babuka, Dennis Fordham, Irina Esikova
  • Methods of protein purification and recovery
    Patent number: 7544354
    Abstract: Improved methods for purification and recovery of interferon-beta (IFN-?) and compositions comprising substantially monomeric IFN-? are provided. In one purification method, substantially purified IFN-? or variant thereof is precipitated and then dissolved in a guanidine hydrochloride (HCl) solution. Renaturation of the protein occurs by dilution with a suitable buffer. A similar purification method absent the precipitation step is also provided. Following renaturation of the IFN-?, residual guanidine HCl is removed by diafiltration or dialysis with a pharmaceutically acceptable buffer to prepare pharmaceutical compositions comprising substantially monomeric IFN-?.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: June 9, 2009
    Assignee: Novartis Vaccines and Diagnostics
    Inventors: Sidney N. Wolfe, Bret A. Shirley, Susan Babuka, Dennis Fordham, Irina Esikova
  • Methods of protein purification and recovery
    Publication number: 20090123424
    Abstract: Improved methods for purification and recovery of interferon-beta (IFN-?) and compositions comprising substantially monomeric IFN-? are provided. In one purification method, substantially purified IFN-? or variant thereof is precipitated and then dissolved in a guanidine hydrochloride (HCl) solution. Renaturation of the protein occurs by dilution with a suitable buffer. A similar purification method absent the precipitation step is also provided. Following renaturation of the IFN-? residual guanidine HCl is removed by diafiltration or dialysis with a pharmaceutically acceptable buffer to prepare pharmaceutical compositions comprising substantially monomeric IFN-?.
    Type: Application
    Filed: April 29, 2008
    Publication date: May 14, 2009
    Inventors: Sidney N. Wolfe, Bret A. Shirley, Susan Babuka, Dennis Fordham, Irina Esikova
  • Methods of protein purification and recovery
    Publication number: 20040115169
    Abstract: Improved methods for purification and recovery of interferon-beta (IFN-&bgr;) and compositions comprising substantially monomeric IFN-&bgr; are provided. In one purification method, substantially purified IFN-&bgr; or variant thereof is precipitated and then dissolved in a guanidine hydrochloride (HCl) solution. Renaturation of the protein occurs by dilution with a suitable buffer. A similar purification method absent the precipitation step is also provided. Following renaturation of the IFN-&bgr;, residual guanidine HCl is removed by diafiltration or dialysis with a pharmaceutically acceptable buffer to prepare pharmaceutical compositions comprising substantially monomeric IFN-&bgr;.
    Type: Application
    Filed: December 31, 2003
    Publication date: June 17, 2004
    Applicant: Chiron Corporation
    Inventors: Sidney N. Wolfe, Bret A. Shirley, Susan Babuka, Dennis Fordham, Irina Esikova
  • Methods of protein purification and recovery
    Publication number: 20020137895
    Abstract: Improved methods for purification and recovery of interferon-beta (IFN-&bgr;) and compositions comprising substantially monomeric IFN-&bgr; are provided. In one purification method, substantially purified IFN-&bgr; or variant thereof is precipitated and then dissolved in a guanidine hydrochloride (HCl) solution. Renaturation of the protein occurs by dilution with a suitable buffer. A similar purification method absent the precipitation step is also provided. Following renaturation of the IFN-&bgr;, residual guanidine HCl is removed by diafiltration or dialysis with a pharmaceutically acceptable buffer to prepare pharmaceutical compositions comprising substantially monomeric IFN-&bgr;.
    Type: Application
    Filed: October 25, 2001
    Publication date: September 26, 2002
    Applicant: Chiron Corporation
    Inventors: Sidney N. Wolfe, Bret A. Shirley, Susan Babuka, Dennis Fordham, Irina Esikova