Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: A method for implementing a Keno-type wagering game may involve providing game tickets. Each game ticket may include a plurality of numbers. The method may also involve receiving completed game tickets from participating players. Each completed game ticket may include a player selection of a certain quantity of the plurality of numbers. The method may also involve holding a drawing in which multiple numbers are chosen. The method may also involve providing payouts to winning players based on how closely the players' number selections on the game tickets match the numbers chosen in the drawing. At least one number chosen in the drawing may be a bonus number that has greater value than other numbers chosen in the drawing.

Abstract: A method for providing personalized rewards to slot machine players may involve defining multiple player categories. The method may also involve providing player category rules. The method may also involve assigning slot machine players to the player categories based on the player category rules. During a gaming session on a slot machine, the method may involve identifying a current player on the slot machine and identifying a player category to which the current player is assigned. In response to detecting a triggering event involving the current player's activity on the slot machine, bonus credits may be awarded to the current player based on the player category that is assigned to the current player.

Abstract: A method for providing a personalized rewards program for slot machine players may involve monitoring activity of slot machine players on one or more slot machines during a reward event. The method may also involve determining reward credits to be provided to the slot machine players. The reward credits that are provided to a player may depend on that player's level of play during the reward event. The method may also involve distributing the reward credits to the slot machine players.