Abstract: A vector friendly instruction format and execution thereof. According to one embodiment of the invention, a processor is configured to execute an instruction set. The instruction set includes a vector friendly instruction format. The vector friendly instruction format has a plurality of fields including a base operation field, a modifier field, an augmentation operation field, and a data element width field, wherein the first instruction format supports different versions of base operations and different augmentation operations through placement of different values in the base operation field, the modifier field, the alpha field, the beta field, and the data element width field, and wherein only one of the different values may be placed in each of the base operation field, the modifier field, the alpha field, the beta field, and the data element width field on each occurrence of an instruction in the first instruction format in instruction streams.

Abstract: There is described herein compounds, compositions and methods for inducing synthetic lethality in a cancer cell(s).

Abstract: The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions.

Abstract: There is described herein compounds, compositions and methods for inducing synthetic lethality in a cancer cell(s).

Abstract: The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions.

Abstract: There is described herein compounds, compositions and methods for inducing synthetic lethality in a cancer cell(s).

Abstract: The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions.

Abstract: There is described herein compounds, compositions and methods for inducing synthetic lethality in a cancer cell(s).

Abstract: The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions.

Abstract: The invention provides novel solid supports comprising dihydroxyalkyl aminoalkyl and dihydroxyalkylaminobenzyl groups, and methods for making and using them. The supports are particularly useful for immobilizing and derivatizing functionalized boronic acids for use in solid phase synthesis, such as those used in combinatorial chemistries. The compositions and methods of the invention are also useful as scavenger solid supports, e.g., in solution-phase parallel synthesis of small molecule libraries, and for use in resin-to-resin transfer reactions via phase transfer of solid supported boronic acids under both aqueous and anhydrous conditions. The methods of the invention provide convergent solid-phase synthesis of symmetrically or unsymmetrically functionalized compounds, such as biphenyl compounds. Also provided are synthesizer devices, e.g., semiautomated parallel synthesizers.

Abstract: The methods of the invention are directed to preparation of dihydroxyalkylaminoalkyl-conjugated solid supports, such as a diethanolamine- or a dipropanolamine-conjugated resin or polystyrene under non-pressurized conditions. The invention also provides novel methods for immobilizing boronic acids.

Abstract: The invention provides novel solid supports comprising dihydroxyalkyl aminoalkyl and dihydroxyalkylaminobenzyl groups, and methods for making and using them. The supports are particularly useful for immobilizing and derivatizing functionalized boronic acids for use in solid phase synthesis, such as those used in combinatorial chemistries. The compositions and methods of the invention are also useful as scavenger solid supports, e.g., in solution-phase parallel synthesis of small molecule libraries, and for use in resin-to-resin transfer reactions via phase transfer of solid supported boronic acids under both aqueous and anhydrous conditions. The methods of the invention provide convergent solid-phase synthesis of symmetrically or unsymmetrically functionalized compounds, such as biphenyl compounds. Also provided are synthesizer devices, e.g., semiautomated parallel synthesizers.

Abstract: Propagation modes within a corrugated optical waveguide are used to excite fluorescence from a layer of material which defines a wall of the waveguide. The fluorescence is emitted at discrete angles, which are a function of the wavelength and polarization of the emitted fluorescence. The intensity of fluorescence detected at the discrete angles of detection can approach 2000 times the intensity detected from the same fluorescence material coated on a glass slide. These features enable a number of tests to be performed simultaneously on an unknown sample, as well as providing a finer and more accurate determination of concentration of a substance over prior art systems.

Abstract: An efficient solid state light emitting device wherein sulphur is used to provide isoelectronic centers in silicon which bind excitons which emit light at a wavelength of 1.32 microns (um) and are particularly adapted for use in integrated opto-electronic circuits and in launching optical signals in single mode optical fibers.

Abstract: Fluorescence enhancement is obtained using an optical waveguide consisting essentially of films of fluorescent molecules and of conductive material separated by a dielectric layer. The enhancement is believed to be due to the near field interaction between the molecules of the fluorescent material and the waveguide modal fields. No special couplers (prisms or gratings) are needed between the fluorescent material and the waveguide. The enhancement factor is in excess of two orders of magnitude over fluorescence from the material without the use of the waveguide.

Abstract: An adjustable holder for mounting a magnetic head so that it can be adjusted for both lateral and angular deviation with respect to the center line of a recording track. The holder includes a carriage adapted to receive guide pins and a yoke carrying the magnetic head on a leg at one end. The yoke is attached to the carriage by a fastener which permits vertical and rotational displacement. The leg of the yoke includes three equally-spaced openings to receive rotational coupling elements, each of which includes a shank having an enlarged head at one end and a flange with a diametrical groove at the other end. The carriage has three fixed pins received within the grooves of respective coupling elements. The axes of the coupling elements define the corners of one equilateral triangle while the axes of the fixed pins define the corners of a similar but non-congruent equilateral triangle.