Abstract: A liquid, water-repellent, substantially anhydrous, spray-pumpable skin protectant composition is disclosed. The composition is designed for spraying directly onto skin, has suitable adherence to the skin, and resists running. The composition contains one or more actives for whichever indication the composition has been formulated, one or more rheology modifiers, and a carrier. The rheology modifiers help give the composition rheological properties such that it can be sprayed using a spray pump dispenser (i.e., a propellant-free, non-pressurized dispenser) but still resist running after it has been applied to the skin. The rheological modifiers can be waxes and/or associative thickeners such as some forms of silica. The carrier can be mineral oil or a mineral oil replacement (e.g., isohexadecane, cyclomethicone). Film-forming components also help the composition resist running. One indication for which the composition may be formulated is diaper rash.