Abstract: A bone cement formed from a hydrogel formed by crosslinking a macromer having a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure and at least two pendant chains bearing crosslinkable groups and an amphiphilic comonomer.

Abstract: Spinal disc implants containing one or more swellable articles such as dehydrated microspheres.

Abstract: A prosthetic spinal disc nucleus pulposus formed from a hydrogel formed by crosslinking a macromer having a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure and at least two pendant chains bearing crosslinkable groups and an amphiphilic comonomer.

Abstract: Compositions comprising macromers having a backbone comprising units having a 1,2-diol and/or 1,3-diol structure for tissue bulking and coating. Such polymers include poly(vinyl alcohol) (PVA) and hydrolyzed copolymers of vinyl acetate, for example, copolymers with vinyl chloride, N-vinylpyrrolidone, etc. The backbone polymer contains pendant chains bearing crosslinkable groups and, optionally, other modifiers. When crosslinked, the macromers form hydrogels having many properties advantageous for use as agents to hulk and coat tissues.

Abstract: A method and device for endoluminally bypassing blood flow through an aneurysm in the vicinity of a branched blood vessel, having a main branch, a first branch, and a second branch.

Abstract: An apparatus and method for insertion of a catheter, such as an IAB catheter, into a blood vessel such that the cross-sectional area of the catheter will be minimized while the circumference of the catheter is maximized. The apparatus is formed as an oval tube of flexible plastic. When placed in a blood vessel, the catheter retains its oval configuration to minimize obstruction to blood flow. During inflation of the balloon bladder at the end of the catheter, the catheter retains its general oval shape. When the catheter is placed in the blood vessel by pre-loading the catheter over a guide wire and inserting the catheter and guide wire without an introducer sheath into the blood vessel both the catheter and its leading balloon bladder are approximately of the same perimeter thereby reducing the possibility of arterial bleeding.

Abstract: Embolic compositions comprising macromers having a backbone comprising a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure, such as polyvinyl alcohol, and pendant chains bearing crosslinkable groups and, optionally, other modifiers. When crosslinked, the macromers form hydrogels having many properties advantageous for use as embolic agents to block and fill lumens and spaces. The embolic compositions can be used as liquid embolic agents and crosslinked in situ or as preformed embolic articles, such as microspheres.