Patents by Inventor Dennis H. Leung

Dennis H. Leung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for preparing stabilized amorphous drug formulations using acoustic fusion
    Patent number: 11344496
    Abstract: The present invention relates to methods for producing a stable amorphous dispersion of a pharmaceutically active substance having poor water solubility by applying low frequency acoustic energy to a mixture comprising the active substance and at least one polymer and heating the mixture until a stable amorphous dispersion is formed. The methods of the invention are an effective means of converting a crystalline API to a substantially amorphous and stable form, i.e., wherein the crystallinity is less than about 5%. The methods of the invention result in more complete amorphization, increased solubility, drug loading and stability as compared typical amorphization or literature methods.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: May 31, 2022
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Dennis H. Leung, Zhiqiang Guo, Christopher W. Boyce
  • METHODS FOR PREPARING STABILIZED AMORPHOUS DRUG FORMULATIONS USING ACOUSTIC FUSION
    Publication number: 20210154138
    Abstract: The present invention relates to methods for producing a stable amorphous dispersion of a pharmaceutically active substance having poor water solubility by applying low frequency acoustic energy to a mixture comprising the active substance and at least one polymer and heating the mixture until a stable amorphous dispersion is formed. The methods of the invention are an effective means of converting a crystalline API to a substantially amorphous and stable form, i.e., wherein the crystallinity is less than about 5%. The methods of the invention result in more complete amorphization, increased solubility, drug loading and stability as compared typical amorphization or literature methods.
    Type: Application
    Filed: August 20, 2018
    Publication date: May 27, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Dennis H. Leung, Zhiqiang Guo, Christopher W. Boyce