Abstract: The present disclosure relates to antisense oligonucleotides that are capable of modulating expression of TMEM106B in a target cell. The antisense oligonucleotides hybridize to TMEM106B mRNA. The present disclosure further relates to methods of using the antisense oligonucleotides described herein.

Abstract: A system includes a product delivery tube having an air inlet, an agricultural product inlet, and an exit nozzle. The agricultural product inlet is disposed between the air inlet and the exit nozzle, and the first product delivery tube is configured to receive the agricultural product from the agricultural product inlet, and to use an air flow received by the air inlet to convey the agricultural product through the exit nozzle. The system also includes a drop tube configured to receive the agricultural product, and to convey the agricultural product at a drop tube angle to the agricultural product inlet. The drop tube angle is formed by a junction between the first drop tube and the first product delivery tube, and the drop tube angle is greater than approximately 0 degrees and less than approximately 90 degrees relative to the product delivery tube.

Abstract: A system includes a product delivery tube having an air inlet, an agricultural product inlet, and an exit nozzle. The agricultural product inlet is disposed between the air inlet and the exit nozzle, and the first product delivery tube is configured to receive the agricultural product from the agricultural product inlet, and to use an air flow received by the air inlet to convey the agricultural product through the exit nozzle. The system also includes a drop tube configured to receive the agricultural product, and to convey the agricultural product at a drop tube angle to the agricultural product inlet. The drop tube angle is formed by a junction between the first drop tube and the first product delivery tube, and the drop tube angle is greater than approximately 0 degrees and less than approximately 90 degrees relative to the product delivery tube.

Abstract: A tool is disclosed, for measuring the important thermal characteristics of a unit of electronic equipment, which obtains air flow and temperature readings at both air inlet and air outlet openings of the unit without disturbing cable or wiring connections or otherwise interrupting device operation. The tool pressure sensing element is rotatable between detented positions to permit the tool to be used at both air inlet and air outlet openings. The tool air duct portion may be formed of separate duct portions to enable a single duct portion including the sensing instrumentation to be used with multiple duct portions that conform to electronic device air inlet and outlet openings to impart added flexibility to the tool.

Abstract: A tool is disclosed, for measuring the important thermal characteristics of a unit of electronic equipment, which obtains air flow and temperature readings at both air inlet and air outlet openings of the unit without disturbing cable or wiring connections or otherwise interrupting device operation. The tool pressure sensing element is rotatable between detented positions to permit the tool to be used at both air inlet and air outlet openings. The tool air duct portion may be formed of separate duct portions to enable a single duct portion including the sensing instrumentation to be used with multiple duct portions that conform to electronic device air inlet and outlet openings to impart added flexibility to the tool.

Abstract: The universal joint includes an outer joint member having a rotational axis and three guide grooves extending parallel to its rotational axis. The three guide grooves are equally circumferentially spaced about the axis and each has opposed side portions. The universal joint also includes an inner joint member disposed inside the outer member. The inner joint member has a rotational axis and three arms equally spaced about this rotational axis extending radially into the guide grooves of the outer joint member. Each aim carries a roller having an external surface which engages the opposed side portions of the guide groove into which the arm extends. The roller is constrained to roll along the guide groove and each roller being able to rotate about, move lengthwise of, and tilt relative to the arm by which it is carried.

Abstract: The present invention relates to a continuous process and a system for macromolecular assembly and capture (refolding or proteins (e.g. refolding of HAT human ?2-microglobulin), hybridization of nucleic acid, nucleic acid analogues, and protein-nucleic acid chimera, aggregation of carbohydrates, and assembly of nanostructures/nanomaterials.

Abstract: The invention provides a constant velocity ratio universal joint of the tripot type. The universal joint includes an outer joint member having a rotational axis and three guide grooves extending parallel to its rotational axis. The three guide grooves are equally circumferentially spaced about the axis and each has opposed side portions. The universal joint also includes an inner joint member disposed inside the outer member. The inner joint member has a rotational axis and three arms equally spaced about this rotational axis extending radially into the guide grooves of the outer joint member. Each arm carries a roller having an external surface which engages the opposed side portions of the guide groove into which the arm extends. The roller is constrained to roll along the guide groove and each roller being able to rotate about, move lengthwise of, and tilt relative to the arm by which it is carried.

Abstract: A system for retaining a fastener within an opening of a first component. The system comprises a fastener including a fastening portion for engaging a portion of a second component to secure the fastener to the second component, and a bearing portion for bearing against the first component when the fastening portion is engaged with the second component, to secure the first component to the second component. At least one tab extends from the first component for retaining the fastener within the opening of the first component so as to permit unobstructed movement of the fastener within the opening, between the bearing portion and the fastening portion, along an axis of the fastener.

Abstract: A multi-purpose trucker's power puller tool with a hook rod that slides in the bore of a handle, and a weighted head at an end of the handle. The weighted head provides momentum to the hooked end for yanking free stuck objects, such as a truck's fifth wheel pin. The slidable rod also allows the tool to be locked in extended or collapsed positions. The invention also allows interchangeable hook rods to be used, so that the tool may be adapted to different purposes, such as grabbing and pulling eyelets of truck load covers, or pulling chains.

Abstract: An apparatus for intraluminal energy treatment and method thereof includes an energy source for insertion into a lumen of a body and having an output end for energy-emission within the lumen and a cooling device with a cooling member adapted to be positioned on the skin surface proximate the lumen along a part of the lumen to be treated for cooling tissue proximate that part of the lumen.

Abstract: A multi-purpose trucker's power puller tool with a hook rod that slides in the bore of a handle, and a weighted head at an end of the handle. The weighted head provides momentum to the hooked end for yanking free stuck objects, such as a truck's fifth wheel pin. The slidable rod also allows the tool to be locked in extended or collapsed positions. The invention also allows interchangeable hook rods to be used, so that the tool may be adapted to different purposes, such as grabbing and pulling eyelets of truck load covers, or pulling chains.

Abstract: The invention provides an apparatus and method that can be applied, for example, to seal a constant velocity joint. In a first aspect, the invention includes a primary boot having a body defining a substantially smooth interior surface and a secondary boot associated with the primary boot and spaced from the interior surface. In a second aspect, the invention includes a constant velocity joint having an outer joint member, an inner joint member positioned in the outer joint member, a plurality of ball members positioned between said outer and inner joint members, and a shaft engaged with and extending from the inner joint member. The primary boot is fixedly associated with respect to the outer joint member and slidably associated with said shaft.

Abstract: A system and method for providing a transmission fluid heat exchanger which is external to an engine radiator, an in-line with respect to radiator hose coupled to the engine radiator.

Abstract: A hot-melt adhesive of ethylene/vinyl acetate copolymer and tackifying resin can be spread into a thin layer that remains tacky for more than 5 seconds, after which a bond can be made without applying heat or more than hand pressure. Within a short period of time, the adhesive crystallizes so that the bond becomes creep-resistant. The temperature at which this hot-melt adhesive can be spread into thin layers is significantly lower than could be used with prior hot-melt adhesives that develop creep resistance.