Patents by Inventor Dennis Henner

Dennis Henner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENRICHMENT METHOD FOR VARIANT PROTEINS WITH ALTERED BINDING PROPERTIES
    Publication number: 20080038717
    Abstract: A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13. The gene fusion is mutated to form a library of structurally related fusion proteins that are expressed in low quantity on the surface of a phagemid particle. Biological selection and screening are employed to identify novel ligands useful as drug candidates. Disclosed are preferred phagemid expression vectors and selected human growth hormone variants.
    Type: Application
    Filed: June 11, 2007
    Publication date: February 14, 2008
    Applicant: Genentech, Inc.
    Inventors: Lisa Garrard, Dennis Henner, Steven Bass, Ronald Greene, Henry Lowman, James Wells, David Matthews
  • Enrichment method for variant proteins with altered binding properties
    Publication number: 20060115874
    Abstract: A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13. The gene fusion is mutated to form a library of structurally related fusion proteins that are expressed in low quantity on the surface of a phagemid particle. Biological selection and screening are employed to identify novel ligands useful as drug candidates. Disclosed are preferred phagemid expression vectors and selected human growth hormone variants.
    Type: Application
    Filed: August 8, 2005
    Publication date: June 1, 2006
    Inventors: Lisa Garrard, Dennis Henner, Steven Bass, Ronald Greene, Henry Lowman, James Wells, David Matthews