Abstract: A closure and container for specimens or the like have interlockable detents which connect together when the closure is forcibly disposed in closing relationship with the container. The upper portion of the container has a dome portion and the closure member has a cooperating dome portion, the detents being formed in the respective dome portions. The detents have surfaces which permit a sealing connection but prevent the release of the closure from the container. The closure member has a neck including a frangible section which must be broken in order to gain entry into the container once closed by the closure member. The closure member also has a cap above the frangible section having screw threads about the exterior periphery which threadedly connect to internal threads within the neck of the closure member adjacent the frangible section so that the container may be reclosed for further use.