Patents by Inventor Dennis J. Hlasta

Dennis J. Hlasta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the ORL-1 receptor
    Patent number: 8741916
    Abstract: The present invention is directed to novel 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor.
    Type: Grant
    Filed: February 14, 2008
    Date of Patent: June 3, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Gilles C. Bignan, Dennis J. Hlasta, Richard R. Ryan
  • 4,4-disubstituted piperidine derivatives useful as inhibitors of dipeptidyl peptidase-1 (DPP-1)
    Patent number: 8686152
    Abstract: The present invention is directed to 4,4-di-substituted piperidine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: April 1, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Bart L. DeCorte, Renee L. DesJarlais, Yifang Huang, Michael H. Parker, Dennis J. Hlasta
  • Alkynyl derivatives useful as DPP-1 inhibitors
    Patent number: 8633322
    Abstract: The present invention is directed to novel alkynyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: January 21, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Michael H. Parker, Dennis J. Hlasta, Yifang Huang, Allen B. Reitz, Edward C. Lawson, Carsten Schubert, Eric Strobel, Brett A. Tounge, Kimberly White, Michael P. Winters, Shyamali Ghosh
  • Bicyclic derivatives useful as inhibitors of DPP-1
    Patent number: 8552032
    Abstract: The present invention is directed to novel bicyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: October 8, 2013
    Assignee: Janssen Pharmaceutica NV
    Inventors: Edward C. Lawson, Dennis J. Hlasta, Shyamali Ghosh, Renee L. DesJarlais, Carsten Schubert
  • Method of producing highly functionalized 1,3-diamino-propan-2-ols from solid support
    Patent number: 8501937
    Abstract: The invention is directed to compounds and methods of synthesizing hydroxyethlamino amides and their use in treatment of aspartyl protease mediated diseases and conditions.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: August 6, 2013
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Steven J. Coats, Dennis J. Hlasta, Mark J. Schulz
  • Substituted benzothiazole and benzoxazole derivatives useful as inhibitors of DPP-1
    Patent number: 8481547
    Abstract: The present invention is directed to substituted benzothiazole and benzoxazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: July 9, 2013
    Assignee: Janssen Pharmaceutica NV
    Inventors: Alfonzo D. Jordan, Renee L. DesJarlais, Dennis J. Hlasta, Michael H. Parker, Carsten Schubert, Kimberly White
  • ?-ketoamide derivatives useful endothelial lipase inhibitors
    Patent number: 8476302
    Abstract: The present invention is directed to ?-ketoamide derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by endothelial lipase, for example, cardiovascular disorders.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: July 2, 2013
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Michael N. Greco, Margery A. Connelly, Shyamali Ghosh, Dennis J. Hlasta, Edward C. Lawson, Eric Strobel, Michele A. Weidner-Wells, Hong Ye
  • METHOD OF PRODUCING HIGHLY FUNCTIONALIZED 1,3-DIAMINO-PROPAN-2-OLS FROM SOLID SUPPORT
    Publication number: 20120184737
    Abstract: The invention is directed to compounds and methods of synthesizing hydroxyethlamino amides and their use in treatment of aspartyl protease mediated diseases and conditions.
    Type: Application
    Filed: March 28, 2012
    Publication date: July 19, 2012
    Inventors: Steve J. Coats, Dennis J. Hlasta, Mark J. Schulz
  • Radiolabelled TRP M8 receptor ligands
    Patent number: 8216547
    Abstract: The present invention is directed to radiolabelled ligands, useful for the labeling and imaging of TRP M8 (transient receptor potential M8 channel) functionality. The present invention is further directed to pharmaceutical compositions comprising the radiolabelled ligands and methods for the preparation of the radiolabelled ligands.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: July 10, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Paul D. Acton, Dennis J. Hlasta, Jay M. Matthews, James J. McNally
  • Method of producing highly functionalized 1,3-diamino-propan-2-ols from solid support
    Patent number: 8168826
    Abstract: The invention is directed to compounds and methods of synthesizing hydroxyethylamino amides and their use in treatment of aspartyl protease mediated diseases and conditions.
    Type: Grant
    Filed: December 3, 2009
    Date of Patent: May 1, 2012
    Assignee: Janssen Pharamcuetica N.V.
    Inventors: Steve J. Coats, Dennis J. Hlasta, Mark J. Schulz
  • ALPHA-KETOAMIDE DERIVATIVES USEFUL ENDOTHELIAL LIPASE INHIBITORS
    Publication number: 20120077847
    Abstract: The present invention is directed to ?-ketoamide derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by endothelial lipase, for example, cardiovascular disorders.
    Type: Application
    Filed: September 26, 2011
    Publication date: March 29, 2012
    Inventors: Michael N. Greco, Margery A. Connelly, Shyamali Ghosh, Dennis J. Hlasta, Edward C. Lawson, Eric Strobel, Michele A. Weidner-Wells, Hong Ye
  • 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1)
    Publication number: 20110224209
    Abstract: The present invention is directed to 4,4-di-substituted piperidine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
    Type: Application
    Filed: March 9, 2011
    Publication date: September 15, 2011
    Inventors: Bart L. DeCorte, Renee L. DesJarlais, Yifang Huang, Michael H. Parker, Dennis J. Hlasta
  • SUBSTITUTED BENZOTHIAZOLE AND BENZOXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF DPP-1
    Publication number: 20110152287
    Abstract: The present invention is directed to substituted benzothiazole and benzoxazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
    Type: Application
    Filed: December 16, 2010
    Publication date: June 23, 2011
    Inventors: Alfonzo D. Jordan, Renee L. DesJarlais, Dennis J. Hlasta, Michael H. Parker, Carsten Schubert, Kimberly White
  • BICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF DPP-1
    Publication number: 20110152321
    Abstract: The present invention is directed to novel bicyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
    Type: Application
    Filed: December 16, 2010
    Publication date: June 23, 2011
    Inventors: Edward C. Lawson, Dennis J. Hlasta, Shyamali Ghosh, Renee L. DesJarlais, Carsten Schubert
  • ALKYNYL DERIVATIVES USEFUL AS DPP-1 INHIBITORS
    Publication number: 20110105562
    Abstract: The present invention is directed to novel alkynyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
    Type: Application
    Filed: October 28, 2010
    Publication date: May 5, 2011
    Inventors: Michael H. Parker, Dennis J. Hlasta, Yifang Huang, Allen B. Reitz, Edward C. Lawson, Carsten Schubert, Eric Strobel, Brett A. Tounge, Kimberly White, Michael P. Winters, Shyamali Ghosh
  • METHOD OF PRODUCING HIGHLY FUNCTIONALIZED 1,3-DIAMINO-PROPAN-2-OLS FROM SOLID SUPPORT
    Publication number: 20100081806
    Abstract: The invention is directed to compounds and methods of synthesizing hydroxyethlamino amides and their use in treatment of aspartyl protease mediated diseases and conditions.
    Type: Application
    Filed: December 3, 2009
    Publication date: April 1, 2010
    Inventors: Steve J. Coats, Dennis J. Hlasta, Mark J. Schulz
  • RADIOLABELLED TRP M8 RECEPTOR LIGANDS
    Publication number: 20100015053
    Abstract: The present invention is directed to radiolabelled ligands, useful for the labeling and imaging of TRP M8 (transient receptor potential M8 channel) functionality. The present invention is further directed to pharmaceutical compositions comprising the radiolabelled ligands and methods for the preparation of the radiolabelled ligands.
    Type: Application
    Filed: July 9, 2009
    Publication date: January 21, 2010
    Inventors: Paul D. Acton, Dennis J. Hlasta, Jay M. Matthews, James J. McNally
  • Method of producing highly functionalized 1,3-diamino-propan-2-ols from solid support
    Patent number: 7649055
    Abstract: The invention is directed to compounds and methods of synthesizing hydroxyethylamino amides and their use in treatment of aspartyl protease mediated diseases and conditions.
    Type: Grant
    Filed: July 1, 2008
    Date of Patent: January 19, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Steve J. Coats, Dennis J. Hlasta, Mark J. Schulz
  • METHOD OF PRODUCING HIGHLY FUNCTIONALIZED 1,3-DIAMINO-PROPAN-2-OLS FROM SOLID SUPPORT
    Publication number: 20080281095
    Abstract: The invention is directed to compounds and methods of synthesizing hydroxyethlamino amides and their use in treatment of aspartyl protease mediated diseases and conditions.
    Type: Application
    Filed: July 1, 2008
    Publication date: November 13, 2008
    Inventors: Steve J. Coats, Dennis J. Hlasta, Mark J. Schulz
  • 1,3,8-TRISUBSTITUTED-1,3,8-TRIAZA-SPIRO[4.5]DECAN-4-ONE DERIVATIVES AS LIGANDS OF THE ORL-1 RECEPTOR
    Publication number: 20080249122
    Abstract: The present invention is directed to novel 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor.
    Type: Application
    Filed: February 14, 2008
    Publication date: October 9, 2008
    Inventors: Gilles C. BIGNAN, Dennis J. Hlasta, Richard R. Ryan