Patents by Inventor Dennis J. Hlavinka
Dennis J. Hlavinka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210016943Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and an occlusion zone encompassing a boundary between the non-breathable section and the breathable section. The non-breathable section is configured to accommodate any of a liquid, a solid, a gas or combination thereof. The breathable section is configured to accommodate only a gas.Type: ApplicationFiled: September 2, 2020Publication date: January 21, 2021Applicant: Terumo BCT Biotechnologies, LLCInventors: Kirk L. WEIMER, Nate T. JOHNSON, Dennis J. HLAVINKA, Kestas P. PARAKININKAS
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Publication number: 20200368645Abstract: Embodiments relate to systems, chambers, and methods for processing particles by washing, concentrating, and/or treating the particles. Some embodiments provide for the processing of cells that may be in a liquid medium (e.g., a liquid in which the cells were grown) and are processed by being washed and concentrated for later use in research or other therapies.Type: ApplicationFiled: August 12, 2020Publication date: November 26, 2020Applicant: Terumo BCT, Inc.Inventors: Timothy Michael TAGA, Anne Baker ORAM, Linda A. TAYLOR, Dennis J. HLAVINKA
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Publication number: 20200368644Abstract: Embodiments relate to systems, chambers, and methods for processing particles by washing, concentrating, and/or treating the particles. Some embodiments provide for the processing of cells that may be in a liquid medium (e.g., a liquid in which the cells were grown) and are processed by being washed and concentrated for later use in research or other therapies.Type: ApplicationFiled: August 12, 2020Publication date: November 26, 2020Applicant: Terumo BCT, Inc.Inventors: Timothy Michael TAGA, Anne Baker ORAM, Linda A. TAYLOR, Dennis J. HLAVINKA
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Patent number: 10793327Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and an occlusion zone encompassing a boundary between the non-breathable section and the breathable section. The non-breathable section is configured to accommodate any of a liquid, a solid, a gas or combination thereof. The breathable section is configured to accommodate only a gas.Type: GrantFiled: October 9, 2018Date of Patent: October 6, 2020Assignee: Terumo BCT Biotechnologies, LLCInventors: Kirk L. Weimer, Nate T. Johnson, Dennis J. Hlavinka, Kestas P. Parakininkas
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Publication number: 20200292231Abstract: Provided is a gas fill fixture for use in lyophilization, a related system and method. The gas fill fixture includes a chassis, fill indicator and a lid, such that the chassis and lid together form a cavity for receiving a flexible lyophilization container. The system includes a lyophilization container, a lyophilizer and a gas fill fixture incorporating a chassis, a fill indicator and a lid. The method includes process steps for using the system to lyophilize a fluid.Type: ApplicationFiled: March 11, 2020Publication date: September 17, 2020Applicant: Terumo BCT Biotechnologies, LLCInventors: Nathaniel T. JOHNSON, Rylan A. SUMMIT, Dennis A. BRIDGES, Dennis J. HLAVINKA, Kestas P. PARAKININKAS, Kirk L. WEIMER, Michael Lawrence GLOVER, Alexander Du NGUYEN, Margaret V. KWIAT
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Publication number: 20200288703Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and a peelable region including a peelable seal encompassing a boundary between the non-breathable section and the breathable section. The method includes inputting a fluid into a non-breathable section of the container, freezing the fluid, applying, in a lyophilization chamber, vacuum pressure, opening the peelable seal using a pressure differential, applying heat energy, sublimating the fluid and creating a temporary occlusion in a peelable region of the container.Type: ApplicationFiled: March 11, 2020Publication date: September 17, 2020Applicant: Terumo BCT Biotechnologies, LLCInventors: Kestas P. PARAKININKAS, Eric T. HANSEN, Kirk L. WEIMER, Nathaniel T. JOHNSON, Dennis J. HLAVINKA
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Patent number: 10765971Abstract: Embodiments relate to systems, chambers, and methods for processing particles by washing, concentrating, and/or treating the particles. Some embodiments provide for the processing of cells that may be in a liquid medium (e.g., a liquid in which the cells were grown) and are processed by being washed and concentrated for later use in research or other therapies.Type: GrantFiled: August 14, 2015Date of Patent: September 8, 2020Assignee: Terumo BCT, Inc.Inventors: Timothy Michael Taga, Anne Baker Oram, Linda A. Taylor, Dennis J. Hlavinka
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Publication number: 20200239822Abstract: Embodiments described herein generally provide for the expansion of cells in a cell expansion system using an active promotion of a coating agent(s) to a cell growth surface in some embodiments. A coating agent may be applied to a surface, such as the cell growth surface of a hollow fiber in a bioreactor, by controlling the movement of a fluid in which a coating agent is suspended, by changing flow rates, by changing flow directions, by rotation of the bioreactor, and/or combinations thereof.Type: ApplicationFiled: April 10, 2020Publication date: July 30, 2020Applicant: Terumo BCT, Inc.Inventors: Nathan D. FRANK, Brian J. NANKERVIS, Dennis J. HLAVINKA, Thomas G. DILORENZO
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Publication number: 20200239819Abstract: Embodiments described herein generally provide for the expansion of cells in a cell expansion system using an active promotion of a coating agent(s) to a cell growth surface. A coating agent may be applied to a surface, such as the cell growth surface of a hollow fiber, by controlling the movement of a fluid in which a coating agent is suspended. Using ultrafiltration, the fluid may be pushed through the pores of a hollow fiber from a first side, e.g., an intracapillary (IC) side, of the hollow fiber to a second side, e.g., an extracapillary (EC) side, while the coating agent is actively promoted to the surface of the hollow fiber. In so doing, the coating agent may be hydrostatically deposited onto a wall, e.g., inner wall, of the hollow fiber.Type: ApplicationFiled: April 10, 2020Publication date: July 30, 2020Applicant: Terumo BCT, Inc.Inventors: Nathan D. FRANK, Brian J. NANKERVIS, Dennis J. HLAVINKA, Thomas G. DILORENZO
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Publication number: 20200149814Abstract: Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.Type: ApplicationFiled: January 7, 2020Publication date: May 14, 2020Applicant: Terumo BCT, Inc.Inventors: Frank CORBIN, III, Dennis J. HLAVINKA, Rajesh PARETA, Mark E. HILLAM
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Publication number: 20200141644Abstract: Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.Type: ApplicationFiled: January 7, 2020Publication date: May 7, 2020Applicant: Terumo BCT, Inc.Inventors: Frank CORBIN, III, Dennis J. HLAVINKA, Rajesh PARETA, Mark E. HILLAM
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Publication number: 20200141646Abstract: Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.Type: ApplicationFiled: January 7, 2020Publication date: May 7, 2020Applicant: Terumo BCT, Inc.Inventors: Frank CORBIN, III, Dennis J. HLAVINKA, Rajesh PARETA, Mark E. HILLAM
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Publication number: 20200141645Abstract: Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.Type: ApplicationFiled: January 7, 2020Publication date: May 7, 2020Applicant: Terumo BCT, Inc.Inventors: Frank CORBIN, III, Dennis J. HLAVINKA, Rajesh PARETA, Mark E. HILLAM
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Publication number: 20200030520Abstract: Embodiments are described for treating a fluid, e.g., a biological fluid. The embodiments may include systems, apparatuses, and methods. Embodiments may provide for a flow cell, with a plurality of manipulation elements, through which a fluid is flowed. The fluid may be treated (e.g., exposed to energy) as it moves through the flow cell. In embodiments, the flow cell may be used to inactivate pathogens in the fluid.Type: ApplicationFiled: July 26, 2019Publication date: January 30, 2020Applicant: Terumo BCT Biotechnologies, LLCInventors: Jon A. DODD, Daniel R. CLEMENT, Dennis J. HLAVINKA, Jeremy T. PARSONS, Haralambos P. APOSTOLOPOULOS
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Publication number: 20200030790Abstract: Embodiments are described for treating a fluid, e.g., a biological fluid. The embodiments may include systems, apparatuses, and methods. Embodiments may provide for a flow cell, with a plurality of manipulation elements, through which a fluid is flowed. The fluid may be treated (e.g., exposed to energy) as it moves through the flow cell. In embodiments, the flow cell may be used to inactivate pathogens in the fluid.Type: ApplicationFiled: July 26, 2019Publication date: January 30, 2020Applicant: Terumo BCT Biotechnologies, LLCInventors: Jon A. DODD, Daniel R. CLEMENT, Dennis J. HLAVINKA, Jeremy T. PARSONS, Haralambos P. APOSTOLOPOULOS
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Patent number: 10539367Abstract: Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.Type: GrantFiled: January 5, 2018Date of Patent: January 21, 2020Assignee: TERUMO BCT, INC.Inventors: Frank Corbin, III, Dennis J. Hlavinka, Rajesh Pareta, Mark E. Hillam
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Publication number: 20190106254Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and an occlusion zone encompassing a boundary between the non-breathable section and the breathable section. The non-breathable section is configured to accommodate any of a liquid, a solid, a gas or combination thereof. The breathable section is configured to accommodate only a gas.Type: ApplicationFiled: October 9, 2018Publication date: April 11, 2019Applicant: Terumo BCT Biotechnologies, LLCInventors: Kirk L. WEIMER, Nate T. JOHNSON, Dennis J. HLAVINKA
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Publication number: 20180304001Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.Type: ApplicationFiled: April 20, 2018Publication date: October 25, 2018Applicant: Terumo BCT, Inc.Inventors: Thomas J. FELT, Dennis J. HLAVINKA, Brian M. HOLMES
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Publication number: 20180128544Abstract: Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.Type: ApplicationFiled: January 5, 2018Publication date: May 10, 2018Applicant: Terumo BCT, Inc.Inventors: Frank CORBIN, III, Dennis J. HLAVINKA, Rajesh PARETA, Mark E. HILLAM
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Publication number: 20180093270Abstract: A modular cassette and method for separating a composite fluid into at least two component parts thereof during centrifugation is provided. The modular cassette includes a fluid inlet portion, at least one fluid separation portion, at least one media chamber in fluid communication with the fluid separation portion, a fluid collection portion, at least one fluidic channel configured to form a fluid communication between at least two components of the cassette, at least one wax valve including undulating flow channel portions configured to close at least one of the fluidic channels, and at least one heating element configured to actuate the at least one wax valve.Type: ApplicationFiled: September 28, 2017Publication date: April 5, 2018Applicant: Terumo BCT, Inc.Inventors: James R. LADTKOW, Dennis J. Hlavinka, Thomas J. Felt, Andrew Gloor, Jesse Janzen, Taylor Polodna, Luke Edwin Ladtkow