Abstract: Described embodiments include a system, method, and computer program product. A described system includes a receiver circuit that receives a first reference image that includes an objective landmark subsurface feature of a mammalian body part, and a second reference image that includes a present-location landmark subsurface feature of the mammalian body part. A feature matching circuit determines a substantial correspondence between the objective landmark subsurface feature and a first atlas subsurface feature, and a substantial correspondence between the present-location landmark subsurface feature and a second atlas subsurface feature. A location analysis circuit determines a fourth spatial relationship between the destination region of interest and a distal end portion of the body-insertable device deployed operationally proximate to the mammalian body part. An indicator circuit generates informational data indicative of the determined fourth spatial relationship.

Abstract: Described embodiments include a system, method, and computer program product. A described system includes an image coregistration circuit that coregisters a first depiction of a region of interest of a mammalian body part during a first condition by a reference medical image and a second depiction of the region of interest of the mammalian body part during a second condition by a target medical image. The coregistration is at least partially based on the first spatial relationship and on the second spatial relationship. The described system includes a computer-readable media configured to maintain informational data corresponding to the coregistration of the first depiction of the region of interest and the second depiction of the region of interest.

Abstract: Described embodiments include a system, method, and computer program product. A described system includes a receiver circuit configured to receive a medical image that includes a region of interest of a mammalian body part, and a reference image that includes a landmark subsurface feature of the mammalian body part, the landmark subsurface feature having a spatial relationship to the region of interest. The system includes a registration circuit configured to register the region of interest and the landmark subsurface feature of the mammalian body part. The system includes a computer-readable, recordable-type media configured to maintain informational data corresponding to the registration of the region of interest and the landmark subsurface feature of the mammalian body part.

Abstract: A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more substrates configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to monitor movement of the one or more body contours; and one or more applicators supported by the one or more substrates and configured to respond to the movement of the one or more body contours by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.

Abstract: A device, a system, or a method is described for treating a disease or condition of one or more joints of articulating bone in a mammalian subject. A device is described which includes one or more substrates configured to contact one or more body contours at one or more joints of articulating bone of a mammalian subject; and an applicator supported by the one or more substrates and configured to inject one or more medicaments to one or more joint tissues of the mammalian subject.

Abstract: Systems, devices, methods, and compositions are described for providing an actively controllable shunt configured to, for example, monitor, treat, or prevent an infection.

Abstract: An active torso support is described. The active torso support may be, for example, an active back brace, and may include one or multiple force applying elements that apply force to localized regions of the torso of a subject. Force applying elements are controlled based upon detection of posture or activity of the subject with a sensor system located at a distance from the active torso support. A signal indicative of posture or activity of the subject is transmitted to the active torso support. In various aspects, the system may include a base station and/or a network of computing devices in communication with the active torso support. Related methods and systems are also described.

Abstract: Described embodiments include a system, method, and computer program product. A described system includes a receiver circuit that receives at least two reference images that each includes a respective landmark subsurface feature of a mammalian body part; and that receives data indicative of a respective spatial relationship among each respective landmark subsurface feature. The system includes a coordinate analysis circuit that determines a common frame of reference at least partially based on a landmark subsurface feature included in a reference image. The system includes a registration circuit that registers the respective landmark subsurface feature of the mammalian body part included in each reference image. The registration is based on the determined common frame of reference and on the data indicative of a respective spatial relationship.

Abstract: Implants responsive to spatiotemporal signal sequences, and methods of operating implants by transmitting spatiotemporal signal sequences.

Abstract: Systems and methods are described for obtaining and acting upon information indicative of circulatory health and related phenomena in human beings or other subjects. Some involve implementing or deploying therapeutic administration systems, for example, for obtaining a priori implant information and signaling a decision whether to initiate implant-site-targeting treatment; or obtaining a flow-change-indicative measurement and signaling a decision whether to administer a clot-reducing agent; or obtaining an indication of a lytic material in a vicinity of a body lumen and accelerating a decrease in a local concentration of the lytic material to extract at least a portion of the lytic material in response to the indication; or a capture component configured to accelerate a decrease in a local concentration of a therapeutic structure along a downstream portion of a vasculature and a dispensation component configured to release the therapeutic structure into an upstream portion of the vasculature.

Abstract: In an aspect, an eating utensil includes a controllable odorant emitter for delivering an odorant to a person who is eating or drinking from the eating utensil. The odorant may be delivered orthonasally or retronasally. The odorant may be used to stimulate or suppress appetite. In an aspect, a controllable odorant emitter is provided in an attachment that may be removably secured to an eating utensil. Related methods and systems for delivering odorant in connection with use of an eating utensil are described.

Abstract: Described embodiments include a handheld or hand operated surgical instrument. The instrument includes an elongated member having a longitudinal axis and a handle portion. The instrument includes a working tip coupled to the elongated member. The instrument includes a sensor configured to detect a user-imparted hand tremble motion. The instrument includes a flexible beam element of the elongated member located in-between the handle portion and the working tip, and configured to reversibly bend, extend, or rotate with respect to the longitudinal axis. The instrument includes an actuator physically coupled to the flexible beam element and configured to reversibly bend, extend, or rotate the flexible beam element with respect to the longitudinal axis. The instrument includes a controller configured to stabilize the working tip by activating the actuator in a manner responsive to the detected user-imparted hand tremble motion in at least one degree of freedom.

Abstract: Breast implants including sensor modules and related methods are described herein. Breast implants include those with: a shell configured to be substantially filled with a viscous material; at least one fluid-permeable cover, the cover completely enveloping the shell; and a plurality of sensor modules attached to the shell and positioned at a distance from each other, each of the sensor modules oriented to detect one or more analytes in a fluid between the shell and the cover, wherein each of the plurality of sensor modules includes a unique identifier and is configured to utilize energy transmitted from an external source.

Abstract: Breast implants including sensor modules and related methods are described herein. Breast implants include those with: a shell configured to be substantially filled with a viscous material; a plurality of projections extending from an external surface of the shell, the projections forming a plurality of compartments adjacent to the external surface of the shell; at least one fluid-permeable cover attached to the projections, the cover completely enveloping the shell and the plurality of projections; a plurality of sensor modules attached to the shell, each of the sensor modules oriented to detect one or more analytes in a fluid within one of the plurality of compartments, wherein each of the plurality of sensor modules includes a unique identifier; and at least one power source operably attached to the plurality of sensor modules.

Abstract: Prosthetic artificial joints are described, including hip, knee and shoulder joints. In some embodiments, a artificial joint prosthesis includes: a bone-facing surface of a artificial joint prosthesis, the bone-facing surface configured to face a bone-prosthesis interface in vivo; a non-contact surface of the artificial joint prosthesis, the non-contact surface adjacent to the bone-facing surface of the artificial joint prosthesis; at least one fluid deflection structure positioned adjacent to the non-contact surface, the fluid deflection structure positioned to deflect synovial fluid away from the bone-prosthesis interface in vivo; and a mechanism attached to the fluid deflection structure, the mechanism operable to move the fluid deflection structure to direct synovial fluid away from the bone-prosthesis interface in vivo.

Abstract: Prosthetic artificial joints are described, including hip, knee and shoulder joints.

Abstract: Prosthetic artificial joints are described, including hip, knee and shoulder joints. In some embodiments, an artificial joint prosthesis includes: a bone-facing surface of a artificial joint prosthesis, the bone-facing surface configured to face a bone-prosthesis interface in vivo; a first component of the artificial joint prosthesis including a contact surface of the artificial joint prosthesis, the first component fabricated from at least one polymer and a plurality of magnetic particles; and a second component of the artificial joint prosthesis including at least one magnet configured to create a magnetic field within the artificial joint, the at least one magnet positioned to form a magnetic field directed to influence a location of debris including the magnetic particles in the joint to a position distinct from the bone-prosthesis interface in vivo.

Abstract: A multilayer material is described herein that includes at least one signaling layer configured to propagate at least one electromagnetic signal; and a flexible layer configured to enclose the at least one signaling layer, wherein the flexible layer is substantially impermeable to an environment and to the at least one electromagnetic signal. The multilayer material including the at least one signaling layer is configured to transmit a change in the at least one electromagnetic signal upon exposure of the signaling layer to the environment. A system, an article of clothing, or a method is described herein.

Abstract: Breast implants including sensor modules and related methods are described herein. Breast implants include those with: a shell configured to be substantially filled with a viscous material; a plurality of projections extending from an external surface of the shell, the projections forming a plurality of compartments adjacent to the external surface of the shell; at least one fluid-permeable cover attached to the projections, the cover completely enveloping the shell and the plurality of projections; and a plurality of sensor modules attached to the shell and positioned at a distance from each other, each of the sensor modules oriented to detect one or more analytes in a fluid within one of the plurality of compartments, wherein each of the plurality of sensor modules includes a unique identifier and is configured to utilize energy transmitted from an external source.

Abstract: Artificial joint prosthetic components including synovial fluid deflection structures are described. Embodiments of artificial joint prosthesis include those with: a bone-facing surface of a artificial joint prosthesis, the bone-facing surface configured to face a bone-prosthesis interface in vivo; a non-contact surface of the artificial joint prosthesis; and at least one fluid deflection structure positioned on the non-contact surface, the fluid deflection structure positioned to deflect synovial fluid away from the bone-prosthesis interface in vivo.