Patents by Inventor Dennis J. Stelzner

Dennis J. Stelzner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nanosphere/microsphere delivery system for the treatment of spinal cord injury
    Patent number: 8765122
    Abstract: A formulation including injectable biodegradable nanospheres and/or microspheres as a delivery system for chondroitinase ABC (cABC) or a functional derivative of cABC to treat acute and chronic spinal chord injury in a mammal having the same is provided. The biodegradable nanosphere/microsphere formulation releases cABC or a functional derivative of cABC in a time-released manner at the site of the spinal cord injury. cABC infusion can promote axon regrowth and some behavioral recovery. The nanospheres and/or microspheres provided herein include cABC or a functional derivative of cABC loaded within and/or on a biodegradable polymer matrix. In some embodiments of the present invention, the surface of the biodegradable polymer matrix can be modified to target a specific scar site. In addition to providing a nanosphere formulation that include polymeric incorporated cABC, a method of treating a mammal having a spinal cord injury is also provided.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: July 1, 2014
    Assignees: The Research Foundation of State University of New York, Syracuse University
    Inventors: Donna J. Osterhout, Julie M. Hasenwinkel, Dennis J. Stelzner
  • Nanosphere/Microsphere Delivery System for the Treatment of Spinal Cord Injury
    Publication number: 20110212136
    Abstract: A formulation including injectable biodegradable nanospheres and/or microspheres as a delivery system for chondroitinase ABC (cABC) or a functional derivative of cABC to treat acute and chronic spinal chord injury in a mammal having the same is provided. The biodegradable nanosphere/microsphere formulation releases cABC or a functional derivative of cABC in a time-released manner at the site of the spinal cord injury. cABC infusion can promote axon regrowth and some behavioral recovery. The nanospheres and/or microspheres provided herein include cABC or a functional derivative of cABC loaded within and/or on a biodegradable polymer matrix. In some embodiments of the present invention, the surface of the biodegradable polymer matrix can be modified to target a specific scar site. In addition to providing a nanosphere formulation that include polymeric incorporated cABC, a method of treating a mammal having a spinal cord injury is also provided.
    Type: Application
    Filed: September 27, 2010
    Publication date: September 1, 2011
    Applicants: The Research Foundation of State University of New York, Syracuse University
    Inventors: Donna J. Osterhout, Julie M. Hasenwinkel, Dennis J. Stelzner