Abstract: A medical instrument clamp for removably securing an elongated medical instrument within a housing to be conductively connected to a conduit. The present invention generally includes a housing having a first opening at its first end and a second opening at its second end. The first opening leads to a first channel adapted to receive an elongated medical instrument such as a catheter guide wire. The second opening leads to a second channel adapted to receive a conduit such as a connection conduit for a medical device. A contact internal to the housing is positioned between the first and second channels to conductively connect the medical instrument with the conduit. A pair of arms and clamp are included which may be transitioned to open or close in response to manipulation of a knob. By closing the arms and clamp, the medical instrument may be removably secured within the first channel.