Abstract: The instant disclosure provides antibodies that specifically bind to T-cell immunoreceptor with Ig and ITIM domains (TIGIT) (e.g., human TIGIT) and antagonize TIGIT function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: A method executed by a computing device includes determining a set of identigens for each query word of a query to produce sets of identigens, where a set of identigens represents different meanings of a word of the query. The method further includes obtaining a first identigen selection for a first query word from the first set of identigens. The method further includes interpreting, using identigen pairing rules and based on the first identigen selection, the sets of identigens to produce a query entigen group. The method further includes accessing a knowledge database utilizing the query entigen group to produce a response entigen group. The method further includes generating a response to the query using the response entigen group, where the response includes at least one response word.

Abstract: A computer system identifies supplemental materials most effective at increasing adherence for each of a plurality of different medications and provides the materials at an optimal point in time. An example method generates a first user interface for receiving an electronic prescription for a patient for a prescribed substance. Responsive to receiving the electronic prescription, the method includes obtaining adherence data for the patient, identifying supplemental programs associated with the prescribed substance from a database of supplemental programs, generating a second user interface that presents the supplemental programs for selection by the health care provider, and responsive to receiving selection of at least one of the supplemental programs in the second user interface, providing the supplemental programs to the patient. The supplemental programs identified from the database are associated with at least one rule relating to adherence data that is met by the adherence data for the patient.

Abstract: A method performed by a computing device includes generating a comparative query entigen group set based on a comparative query in accordance with identigen rules, where the comparative query entigen group set represents a most likely interpretation of the comparative query. The method further includes obtaining a first response entigen group from a knowledge database based on a first comparative query entigen group of the comparative query entigen group set, where the first response entigen group substantially includes the first comparative query entigen group. The method further includes obtaining a second response entigen group from the knowledge database based on a second comparative query entigen group of the comparative query entigen group set, where the second response entigen group substantially includes the second comparative query entigen group. The method further includes generating a comparative response based on the first response entigen group and the second response entigen group.

Abstract: The present disclosure generally relates to camera and visitor user interfaces. In some examples, the present disclosure relates to techniques for switching between configurations of a camera view. In some examples, the present disclosure relates to displaying indications of visitors detected by an accessory device of the home automation system. In some examples, the present disclosure relates to displaying a multi-view camera user interface.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: A method executed by a computing device includes determining a set of identigens for each phrase word of a phrase to produce sets of identigens. A set of identigens of the sets of identigens represents one or more different meanings of a phrase word of the phrase. The method further includes obtaining sensor information for one or more phrase words of the phrase. The method further includes selecting an identigen of a first set of identigens based on the sensor information to produce a first identigen selection for the first set of identigens having a selected meaning of one or more different meanings of the first phrase word. The method further includes interpreting remaining sets of identigens of the sets of identigens to produce an entigen group so that the entigen group represents a most likely meaning interpretation of the phrase.

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

Abstract: Antibodies that specifically bind to TIM 3 and antagonize TIM-3 function pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: A method of deliquification of production wells includes placing an artificial lift tool in a gas wellbore, where the artificial lift tool includes a rack and multiple piezoelectric transducers. The rack includes multiple trays. Each piezoelectric transducer of the multiple piezoelectric transducers is positioned on a respective tray of the multiple trays. The method further includes providing, by a pump, a liquid on surfaces of the multiple piezoelectric transducers and providing, by a signal source, an electrical signal to the multiple piezoelectric transducers. The method also includes generating, by the multiple piezoelectric transducers, acoustic waves from the electrical signal, where at least some of the liquid provided to the multiple piezoelectric transducers is atomized by the acoustic waves.

Abstract: A phytosanitary treatment blockchain is generated from automatically gathered phytosanitary treatment records. The phytosanitary treatment records are generated by matching authenticated treatment data with authenticated identification data. Matching may be based on geolocation, timestamps, or both. Authentication may be based on digital signatures using private key encryption. Separate treatment sensors and identification sensors automatically gather information about a phytosanitary treatment and the item being treated. The gathered information is encrypted and transmitted to blockchain members that perform authentication, matching, and generation of the phytosanitary treatment blockchain. A tracking code may be issued for each treatment. The tracking code is used to obtain an authentication of the treatment that indicates whether the treatment passed or failed.

Abstract: The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: An airport runway arrangement for commercial aircraft comprises a first runway section, a second runway section extending substantially in prolongation of the first runway section and an intermediate section between the first and second runway sections.

Abstract: Provided are novel antigenic polypeptides comprising tumor-associated peptides, and compositions comprising the same. Such antigenic polypeptides and compositions are particularly useful as immunotherapeutics (e.g., cancer vaccines). Also provided are methods of inducing a cellular immune response using the polypeptides and compositions, methods of treating a disease using the polypeptides and compositions, kits comprising the polypeptides and compositions, methods of making the compositions, and antibodies and T cell receptors that specifically bind to the polypeptides.

Abstract: The instant disclosure provides antibodies that specifically bind to CD137 (e.g., human CD137) and increases CD137 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: A phytosanitary treatment blockchain is generated from automatically gathered phytosanitary treatment records. The phytosanitary treatment records are generated by matching authenticated treatment data with authenticated identification data. Matching may be based on geolocation, timestamps, or both. Authentication may be based on digital signatures using private key encryption. Separate treatment sensors and identification sensors automatically gather information about a phytosanitary treatment and the item being treated. The gathered information is encrypted and transmitted to blockchain members that perform authentication, matching, and generation of the phytosanitary treatment blockchain. A tracking code may be issued for each treatment. The tracking code is used to obtain an authentication of the treatment that indicates whether the treatment passed or failed.

Abstract: A system for servicing cable includes a field-end assembly and a live-end assembly, each mounted on a support structure having at least one drive mechanism operable to cause relative linear movement between the field-end assembly and the live-end assembly. A drilling-and-shorting assembly can create a short circuit in a field-end of the cable, and a continuity tester can test the integrity of the short-circuit. The field end of the cable can then be ejected from the system, and an end-cap-cradle assembly can position an end cap on a live end of an electrical cable and test its installation.

Abstract: A runway arrangement comprising: a first runway section (202-1) designated as a landing runway section; a second runway section (202-2) designated as a take-off runway section; and a sterile safety area (210); wherein the first and second runway sections are linked by the sterile safety area (210); the runway arrangement comprising a missed approach point for aircraft due to land on the first runway section, displaced from the start of the second runway section (202-2) by a distance greater than H/tan ?1; where H is a safe turning height and ?1 is an angle of ascent following a missed approach; wherein H is greater than 150 m and ?1 is greater than 2°.

Abstract: The instant disclosure provides antibodies that specifically bind to CD137 (e.g., human CD137) and increases CD137 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: The instant disclosure provides antibodies that specifically bind to T-cell immunoreceptor with Ig and ITIM domains (TIGIT) (e.g., human TIGIT) and antagonize TIGIT function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.