Abstract: Blends of monofunctional and multifunctional (meth)acrylate monomers, optionally in addition to oligomeric multifunctional (meth)acrylates), can be cured by ultraviolet radiation in contact with a photoinitiator to produce optical resinous articles having a glass transition temperature of at least 35° C. and having physical properties making them suitable for use as microstructure-bearing articles.

Abstract: The present invention provides substituted 2-aminopyridines of formula I, wherein R1, A1, W, X, and Y are as defined in the specification, useful in treating cell proliferative disorders.

Abstract: The disclosure relates to methods for ascertaining the corrosion resistant effectiveness of a silica containing film or layer upon a metal surface. The disclosed methods employ colormetric as well as chemical leaching processes. The effectiveness of the silica containing film or layer is dependent upon the uniformity, lack of porosity, micro-cracks, among other potential defects in the silica containing film or layer that affect the ability of the film or layer to protect an underlying metal surface from corrosive environments.

Abstract: A paper dispenser including a carriage that is rotatable between at least a first orientation and a second orientation. The carriage holds at least two rolls of paper. In the first orientation, the first roll is in a primary position and the second roll is in a secondary position. In the second orientation, the first roll is in the secondary position and the second roll is in the primary position. A roll sensor senses the amount of paper remaining on the roll held in the primary position. Paper from at least one of the two rolls is fed into a feed mechanism for dispensation. A transfer mechanism feeds paper from the roll held in the secondary position into the feed mechanism when the roll sensor senses that the paper on the roll held in the primary position is depleted to less than a predetermined diameter.

Abstract: The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.

Abstract: Apparatus for dispensing paper from rolls which feeds continuously, roll to roll, and does not require extra procedure to bring stub roll into position. The apparatus has means for holding and positioning at least first and second rolls of paper with respect to each other; means for dispensing paper from the first roll; means for dispensing paper from the first and second rolls simultaneously when the first roll reduces to a predetermined diameter of paper, means for positioning the depleted first roll for replacement without the necessity of removing the second roll; and means for dispensing from the second and replacement rolls simultaneously when the second roll reduces to a predetermined diameter of paper. The apparatus also has a proximity sensor, which senses when a hand is placed near the dispenser, and thereupon dispenses a set amount of towel. The proximity sensor incorporates “static” and noise immunity circuitry.

Abstract: Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula 1 are disclosed. Such inhibitors, which include N-[4-(3-chloro-4-floro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, are useful for treating cancer, restenosis, atherosclerosis, endometriosis and psoriasis. The disclosed methods employ protecting schemes to minimize undesirable diacryloylamino-quinazoline side products.

Abstract: An apparatus for producing a thermoplastic film having low-birefringent, low stress and at least one polished surface for optical media applications as well as low stress film for non-optical applications using a continuous extrusion process. The apparatus consists of a novel calendering roll in a calendering roll stack wherein, at least one roll consists of an inner steel shell, a resilient covering over the inner steel roll and a multi-layer metal sleeve outer covering of at least two layers. The metal sleeve preferably consists of three layers. The inner layer of the multi-layer outer sleeve is preferably nickel, the intermediate layer is preferably copper and the outer layer is preferably chrome with a highly polished surface. The film produced by the process has a retardation value (birefringence times thickness) of less than about 100 nanometers and a surface roughness of less than about 4 microinches.

Abstract: Blends of oligomeric urethane multi(meth)acrylate; optionally at least one other monomer selected from the group consisting of acrylic monomers, styrenic monomers and ethylenically unsaturated nitrogen heterocycles, preferably a polyol multi(meth)acrylate; and nanoparticles of an ethylenically unsaturated, preferably (meth)acrylic-functionalized, titanium or zirconium compound can be cured by ultraviolet radiation in contact with a photoinitiator to produce optical resinous articles having high refractive indices, haze ratings of at most 5% and other properties which may be tailored according to the desired use.

Abstract: Blends of monofunctional and multifunctional (meth)acrylate monomers, optionally in addition to oligomeric multifunctional (meth)acrylates), can be cured by ultraviolet radiation in contact with a photoinitiator to produce optical resinous articles having a glass transition temperature of at least 35° C. and having physical properties making them suitable for use as microstructure-bearing articles.

Abstract: The present invention provides compounds having the structure represented by Formula I: and methods of treating cancer, restenosis, atherosclerosis, or psoriasis or preventing restenosis, and a pharmaceutical composition comprising a compound of Formula I and a pharmaceutically acceptable carrier.

Abstract: The present invention provides compounds of Formula II: 1

Abstract: The present invention provides compounds that are irreversible inhibitors of tyrosine kinases. Also provided is a method of treating cancer, restenosis, atherosclerosis, endometriosis, and psoriasis and a pharmaceutical composition that comprises a compound that is an irreversible inhibitor of tyrosine kinases.

Abstract: A paper dispenser including a carriage that is rotatable between at least a first orientation and a second orientation. The carriage holds at least two rolls of paper. In the first orientation, the first roll is in a primary position and the second roll is in a secondary position. In the second orientation, the first roll is in the secondary position and the second roll is in the primary position. A roll sensor senses the amount of paper remaining on the roll held in the primary position. Paper from at least one of the two rolls is fed into a feed mechanism for dispensation. A transfer mechanism feeds paper from the roll held in the secondary position into the feed, mechanism when the roll sensor senses that the paper on the roll held in the primary position is depleted to less than a predetermined diameter.

Abstract: The present invention provides compounds that are irreversible inhibitors of tyrosine kinases. Also provided is a method of treating cancer, restenosis, atherosclerosis, endometriosis, and psoriasis and a pharmaceutical composition that comprises a compound that is an irreversible inhibitor of tyrosine kinases.

Abstract: Apparatus for dispensing paper from rolls which feeds continuously, roll to roll, and does not require extra procedure to bring stub roll into position. The apparatus has a device for holding and positioning at least first and second rolls of paper with respect to each other; a device for dispensing paper from the first roll; a device for dispensing paper from the first and second rolls simultaneously when the first roll reduces to a predetermined diameter of paper, a device for positioning the depleted first roll for replacement without the necessity of removing the second roll; and a device for dispensing from the second and replacement rolls simultaneously when the second roll reduces to a predetermined diameter of paper. The apparatus also has a capacity-change based proximity sensor comprising a circuit according to a balanced bridge principle where detection is based on detecting a phase difference, which depends upon the amount of detected capacitance difference or change.

Abstract: Disclosed are compounds of Formulae (Ia), (Ib), (Ic), (Id) wherein: W is NH, S, SO, or SO2; R2 is (un)substituted aryl, (un)substituted heteroaryl, or (un)substituted carbocycle or heterocycle; Q is hydrogen or lower alkyl; R4 and R6 are the same or different and represent hydrogen, halogen, lower alkyl, lower alkoxy, (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl; and R8 is hydrogen, lower alkyl or an (un)substituted carbocyclic group containing from 3-7 members, up to two of which members are optionally hetero atoms selected from oxygen and nitrogen; or R8 is (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl. These compounds are useful for treating cell proliferative disorders, such as cancer and restenosis. These compounds are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases.

Abstract: A method for producing articles bearing patterned microstructures, e.g., optical film, information carrying substrates for optical recording media, etc. includes applying a radiation curable coating material to a surface of a base film substrate, passing the base film substrate and uncured coating through a compression nip defined by a nip roll and a casting drum having pattern master of the microstructures. The method further includes curing the radiation curable coating by directing radiation energy through the base film substrate from the surface opposite the surface having the coating thereon while the coating is in contact with the drum, thus causing microstructure pattern to be replicated in the cured coating layer.

Abstract: A process for producing low birefringence and low stress thermoplastic polycarbonate film having a birefringence of less than about 20 nm from polycarbonate resin. The process consists of feeding a polycarbonate resin to an extruder, melting the polycarbonate resin, extruding the melted polycarbonate resin downwardly through an extrusion nozzle having the configuration of, forming a continuous film of melted resin, advancing the melted resin downwardly by essentially gravity into a gap between two calendering rolls which lie in a plane essentially perpendicular to the downward extrusion of the resin, cooling the polycarbonate film to below its glass transition temperature and advancing the cooled polymer to storage. The calendering rolls lie in a plane essentially perpendicular to the downward extrusion of the melted resin to wherein one roll is in a plane at an angle of about 30° from said perpendicular. The film is useful for optical media applications.

Abstract: Disclosed are compounds of the formula (I) wherein: R2, R7, RI3, R14 and R15 are independently hydrogen, or (un)substituted lower alkyl, (un)substitued lower alkenyl, (un)substituted lower alkynyl, or (un)substituted —(CH2)nR12; R5 is halogen, cyano, nitro, —R9, —NR9R10, or —OR9; R6 is halogen, cyano, nitro, —R9, —NR9R10, —OR9, —Co2R9, —COR9, —CONR9R10, —NR9COR10, (un)substiuted lower alkenyl, or (un)substituted lower alkynyl; R8 is —CO2R13, —COR13, —CONR13R14, —CSNR13R14, —C(NR13)NR14R15, —SO3R13, —SO2R13, —SO2NR13R14, —PO3R13R14, —POR13R14, —PO(NR13R14)2; R9 and R10 are independently hydrogen or (un)substituted lower alkyl; R11 is a heteroaryl or a heterocyclic group; R12 is a cycloalkyl, a heterocyclic, an aryl, or a heteroaryl group; and n is 0,1,2, or 3.