Patents by Inventor Dennis L. Matthews
Dennis L. Matthews has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9366668Abstract: A device and array coupled to capture molecules are provided. Specifically, the device and array can be used for detecting the presence and concentration of biomarkers in a sample from a subject. The device and array can also allow the use of a method for scoring a sample for, e.g., the purpose of diagnosing a disease. The method can also be advantageous to applications where there is a need to accurately determine the disease stage of a subject for the purpose of making therapeutic decisions.Type: GrantFiled: August 21, 2014Date of Patent: June 14, 2016Assignee: Lawrence Livermore National Security, LLCInventors: Rupa S. Rao, Stephen M. Lane, Dennis L. Matthews, Matthew A. Coleman
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Publication number: 20150087543Abstract: A device and array coupled to capture molecules are provided. Specifically, the device and array can be used for detecting the presence and concentration of biomarkers in a sample from a subject. The device and array can also allow the use of a method for scoring a sample for, e.g., the purpose of diagnosing a disease. The method can also be advantageous to applications where there is a need to accurately determine the disease stage of a subject for the purpose of making therapeutic decisions.Type: ApplicationFiled: August 21, 2014Publication date: March 26, 2015Inventors: Rupa S. Rao, Stephen M. Lane, Dennis L. Matthews, Matthew A. Coleman
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Patent number: 8428398Abstract: A hand-held portable microarray reader for biodetection includes a microarray reader engineered to be small enough for portable applications. The invention includes a high-powered light-emitting diode that emits excitation light, an excitation filter positioned to receive the excitation light, a slide, a slide holder assembly for positioning the slide to receive the excitation light from the excitation filter, an emission filter positioned to receive the excitation light from the slide, a lens positioned to receive the excitation light from the emission filter, and a CCD camera positioned to receive the excitation light from the lens.Type: GrantFiled: June 29, 2010Date of Patent: April 23, 2013Assignees: Lawrence Livermore National Security, LLC, The Regents of the University of CaliforniaInventors: Deanna Lynn Thompson, Matthew A. Coleman, Stephen M. Lane, Dennis L. Matthews, Joanna Albala, Sebastian Wachsmann-Hogiu
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Publication number: 20110188782Abstract: A hand-held portable microarray reader for biodetection includes a microarray reader engineered to be small enough for portable applications. The invention includes a high-powered light-emitting diode that emits excitation light, an excitation filter positioned to receive the excitation light, a slide, a slide holder assembly for positioning the slide to receive the excitation light from the excitation filter, an emission filter positioned to receive the excitation light from the slide, a lens positioned to receive the excitation light from the emission filter, and a CCD camera positioned to receive the excitation light from the lens.Type: ApplicationFiled: June 29, 2010Publication date: August 4, 2011Inventors: Deanna Lynn Thompson, Matthew A. Coleman, Stephen M. Lane, Dennis L. Matthews, Joanna Albala, Sebastian Wachsmann-Hogiu
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Publication number: 20080200342Abstract: A device and array coupled to capture molecules are provided. Specifically, the device and array can be used for detecting the presence and concentration of biomarkers in a sample from a subject. The device and array can also allow the use of a method for scoring a sample for, e.g., the purpose of diagnosing a disease. The method can also be advantageous to applications where there is a need to accurately determine the disease stage of a subject for the purpose of making therapeutic decisions.Type: ApplicationFiled: February 14, 2008Publication date: August 21, 2008Inventors: Rupa S. Rao, Stephen M. Lane, Dennis L. Matthews, Matthew A. Coleman
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Patent number: 7291154Abstract: An actuator system is provided for acting upon a material in a vessel. The system includes an optical fiber and a shape memory polymer material operatively connected to the optical fiber. The shape memory polymer material is adapted to move from a first shape for moving through said vessel to a second shape where it can act upon said material.Type: GrantFiled: November 13, 2003Date of Patent: November 6, 2007Assignee: The Regents of the University of CaliforniaInventors: Duncan J. Maitland, Abraham P. Lee, Daniel L. Schumann, Dennis L. Matthews, Derek E. Decker, Charles A. Jungreis
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Publication number: 20040133231Abstract: An actuator system is provided for acting upon a material in a vessel. The system includes an optical fiber and a shape memory polymer material operatively connected to the optical fiber. The shape memory polymer material is adapted to move from a first shape for moving through said vessel to a second shape where it can act upon said material.Type: ApplicationFiled: November 13, 2003Publication date: July 8, 2004Applicant: The Regents of the University of CaliforniaInventors: Duncan J. Maitland, Abraham P. Lee, Daniel L. Schumann, Dennis L. Matthews, Derek E. Decker, Charles A. Jungreis
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Patent number: 6740094Abstract: An actuator system is provided for acting upon a material in a vessel. The system includes an optical fiber and a shape memory polymer material operatively connected to the optical fiber. The shape memory polymer material is adapted to move from a first shape for moving through said vessel to a second shape where it can act upon said material.Type: GrantFiled: January 16, 2001Date of Patent: May 25, 2004Assignee: The Regents of the University of CaliforniaInventors: Duncan J. Maitland, Abraham P. Lee, Daniel L. Schumann, Dennis L. Matthews, Derek E. Decker, Charles A. Jungreis
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Patent number: 6575965Abstract: A medical device is constructed in the basic form of a catheter having a distal end for insertion into and manipulation within a body and a proximal end providing for a user to control the manipulation of the distal end within the body. A fiberoptic cable is disposed within the catheter and having a distal end proximate to the distal end of the catheter and a proximal end for external coupling of laser light energy. A laser-light-to-mechanical-power converter is connected to receive light from the distal end of the fiber optic cable and may include a photo-voltaic cell and an electromechanical motor or a heat-sensitive photo-thermal material. An electronic sensor is connected to receive electrical power from said distal end of the fiberoptic cable and is connected to provide signal information about a particular physical environment and communicated externally through the fiberoptic cable to the proximal end thereof.Type: GrantFiled: November 16, 2000Date of Patent: June 10, 2003Assignee: The Regents of the University of CaliforniaInventors: Joseph P. Fitch, Dennis L. Matthews, Karla G. Hagans, Abraham P. Lee, Peter Krulevitch, William J. Benett, Robert E. Clough, Luiz B. DaSilva, Peter M. Celliers
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Publication number: 20020095169Abstract: An actuator system is provided for acting upon a material in a vessel. The system includes an optical fiber and a shape memory polymer material operatively connected to the optical fiber. The shape memory polymer material is adapted to move from a first shape for moving through said vessel to a second shape where it can act upon said material.Type: ApplicationFiled: January 16, 2001Publication date: July 18, 2002Applicant: The Regents of the University of CaliforniaInventors: Duncan J. Maitland, Abraham P. Lee, Daniel L. Schumann, Dennis L. Matthews, Derek E. Decker, Charles A. Jungreis
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Patent number: 6233479Abstract: The Microwave Hematoma Detector is a non-invasive device designed to detect and localize blood pooling and clots near the outer surface of the body. While being geared towards finding sub-dural and epi-dural hematomas, the device can be used to detect blood pooling anywhere near the surface of the body. Modified versions of the device can also detect pneumothorax, organ hemorrhage, atherosclerotic plaque in the carotid arteries, evaluate perfusion (blood flow) at or near the body surface, body tissue damage at or near the surface (especially for burn assessment) and be used in a number of NDE applications. The device is based on low power pulsed microwave technology combined with a specialized antenna, signal processing/recognition algorithms and a disposable cap worn by the patient which will facilitate accurate mapping of the brain and proper function of the instrument.Type: GrantFiled: September 15, 1998Date of Patent: May 15, 2001Assignee: The Regents of the University of CaliforniaInventors: Waleed S. Haddad, James E. Trebes, Dennis L. Matthews
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Patent number: 5986234Abstract: A compact laser system that removes surface coatings (such as paint, dirt, etc.) at a removal rate as high as 1000 ft.sup.2 /hr or more without damaging the surface. A high repetition rate laser with multiple amplification passes propagating through at least one optical amplifier is used, along with a delivery system consisting of a telescoping and articulating tube which also contains an evacuation system for simultaneously sweeping up the debris produced in the process. The amplified beam can be converted to an output beam by passively switching the polarization of at least one amplified beam. The system also has a personal safety system which protects against accidental exposures.Type: GrantFiled: March 28, 1997Date of Patent: November 16, 1999Assignee: The Regents of the University of CaliforniaInventors: Dennis L. Matthews, Peter M. Celliers, Lloyd Hackel, Luiz B. Da Silva, C. Brent Dane, Stanley Mrowka
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Patent number: 5912945Abstract: An apparatus and method for determining the orientation of a device with respect to an x-ray source. In one embodiment, the present invention is coupled to a medical device in order to determine the rotational orientation of the medical device with respect to the x-ray source. In such an embodiment, the present invention is comprised of a scintillator portion which is adapted to emit photons upon the absorption of x-rays emitted from the x-ray source. An x-ray blocking portion is coupled to the scintillator portion. The x-ray blocking portion is disposed so as to vary the quantity of x-rays which penetrate the scintillator portion based upon the particular rotational orientation of the medical device with respect to the x-ray source. A photon transport mechanism is also coupled to the scintillator portion. The photon transport mechanism is adapted to pass the photons emitted from the scintillator portion to an electronics portion.Type: GrantFiled: June 23, 1997Date of Patent: June 15, 1999Assignee: Regents of the University of CaliforniaInventors: Luiz B. Da Silva, Dennis L. Matthews, Joseph P. Fitch, Matthew J. Everett, Billy W. Colston, Gary F. Stone
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Patent number: 5722989Abstract: A micro-mechanical system for medical procedures is constructed in the basic form of a catheter having a distal end for insertion into and manipulation within a body and a near end providing for a user to control the manipulation of the distal end within the body. A fiberoptic cable is disposed within the catheter and having a distal end proximate to the distal end of the catheter and a near end for external coupling of laser light energy. A microgripper is attached to the distal end of the catheter and providing for the gripping or releasing of an object within the body. A laser-light-to-mechanical-power converter is connected to receive laser light from the distal end of the fiberoptic cable and connected to mechanically actuate the microgripper.Type: GrantFiled: March 6, 1997Date of Patent: March 3, 1998Assignee: The Regents of the University of CaliforniaInventors: Joseph P. Fitch, Karla Hagans, Robert Clough, Dennis L. Matthews, Abraham P. Lee, Peter A. Krulevitch, William J. Benett, Luiz Da Silva, Peter M. Celliers
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Patent number: 5720894Abstract: A method and apparatus is disclosed for fast, efficient, precise and damage-free biological tissue removal using an ultrashort pulse duration laser system operating at high pulse repetition rates. The duration of each laser pulse is on the order of about 1 fs to less than 50 ps such that energy deposition is localized in a small depth and occurs before significant hydrodynamic motion and thermal conduction, leading to collateral damage, can take place. The depth of material removed per pulse is on the order of about 1 micrometer, and the minimal thermal and mechanical effects associated with this ablation method allows for high repetition rate operation, in the region 10 to over 1000 Hertz, which, in turn, achieves high material removal rates. The input laser energy per ablated volume of tissue is small, and the energy density required to ablate material decreases with decreasing pulse width.Type: GrantFiled: January 11, 1996Date of Patent: February 24, 1998Assignee: The Regents of the University of CaliforniaInventors: Joseph Neev, Luiz B. Da Silva, Dennis L. Matthews, Michael E. Glinsky, Brent C. Stuart, Michael D. Perry, Michael D. Feit, Alexander M. Rubenchik
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Patent number: 5016250Abstract: An X-ray laser (10), and related methodology, are disclosed wherein an X-ray laser target (12) is illuminated with a first pulse of optical laser radiation (14) of relatively long duration having scarcely enough energy to produce a narrow and linear cool plasma of uniform composition (38). A second, relatively short pulse of optical laser radiation (18) is uniformly swept across the length, from end to end, of the plasma (38), at about the speed of light, to consecutively illuminate continuously succeeding portions of the plasma (38) with optical laser radiation having scarcely enough energy to heat, ionize, and invert them into the continuously succeeding portions of an X-ray gain medium. This inventive double pulse technique results in a saving of more than two orders of magnitude in driving optical laser energy, when compared to the conventional single pulse approach.Type: GrantFiled: October 18, 1989Date of Patent: May 14, 1991Assignee: The United States of America as represented by the United States Department of EnergyInventors: Mordecai D. Rosen, Dennis L. Matthews
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Patent number: 4731786Abstract: A method and apparatus is disclosed for producing ultraviolet or X-ray laser pulses of short duration (32). An ultraviolet or X-ray laser pulse of long duration (12) is progressively refracted, across the surface of an opaque barrier (28), by a streaming plasma (22) that is produced by illuminating a solid target (16, 18) with a pulse of conventional line focused high power laser radiation (20). The short pulse of ultraviolet or X-ray laser radiation (32), which may be amplified to high power (40, 42), is separated out by passage through a slit aperture (30) in the opaque barrier (28).Type: GrantFiled: May 5, 1987Date of Patent: March 15, 1988Assignee: The United States of America as represented by the United States Department of EnergyInventors: Brian J. MacGowan, Dennis L. Matthews, James E. Trebes