Abstract: Described here are devices, systems, and methods for applying pulsed or modulated electric fields to tissue. In some variations, a method of treating a target tissue may comprise advancing a pulsed electric field device and a visualization device to the target tissue of a patient. The pulsed electric field device may comprise an elongate body and an expandable member coupled to the elongate body. A suction catheter may be advanced from a lumen of the visualization device. Suction may be applied to the portion of the target tissue through the one or more fluid openings of the expandable member using the suction catheter. A pulsed waveform may be delivered to an electrode array of the pulsed electric field device to generate a pulsed or modulated electric field thereby treating the target tissue.

Abstract: A medical system may include an external medical device, at least two patient-applied parts, and a furcated cable having one proximal end configured to be connected to the external medical device and having at least first and second distal ends configured to be connected to the patient-applied parts. The cable may include first and second types of twisted wire pairs. The second type includes wires that have a lower gauge and higher current capacity than the first type. The cable may include at least four sets of twisted wire pairs, including at least two sets of twisted wire pairs of the first type and at least two sets of twisted wire pairs of the second type. Each of the first and second distal ends include a first type and a second type of twisted wire pairs.

Abstract: A method of producing a drug coated balloon that comprises the steps of: subjecting a balloon catheter with a folded and wrapped balloon thereon to a pre-annealing step to induce a fold/wrap memory in the resulting pre-annealed balloon; unfolding the pre-annealed balloon sufficiently to expose the full circumferential surface of the balloon by application of an inflation pressure that retains said fold/wrap memory; applying a drug coating formulation to the unfolded balloon surface; releasing pressure to relax the balloon and induce creasing along fold memory; and evacuating the balloon slowly to induce refolding and rewrapping of the balloon. The method overcomes the need to use a folding apparatus to fold and wrap a drug coated balloon.

Abstract: A method of producing a drug coated balloon that comprises the steps of: subjecting a balloon catheter with a folded and wrapped balloon thereon to a pre-annealing step to induce a fold/wrap memory in the resulting pre-annealed balloon; unfolding the pre-annealed balloon sufficiently to expose the full circumferential surface of the balloon by application of an inflation pressure that retains said fold/wrap memory; applying a drug coating formulation to the unfolded balloon surface; releasing pressure to relax the balloon and induce creasing along fold memory; and evacuating the balloon slowly to induce refolding and rewrapping of the balloon. The method overcomes the need to use a folding apparatus to fold and wrap a drug coated balloon.

Abstract: An embodiment of a system for gathering physiologic data related to a human body includes a sensor device implanted in the human body, an inductive coil communicably coupled to the implanted sensor device; and a manager device in communication with the implanted sensor device via the inductive coil. The coil may be wrapped around the sensor device or attached to the sensor device fixation. An embodiment of a method for gathering physiologic data related to a physiologic parameter in a human body includes communicably coupling an inductive coil to communication circuitry of an implantable medical device (IMD), deploying the inductive coil and the IMD into a vessel of the human body, and inducing current in the inductive coil via the communication circuitry, the current representative of data associated with the IMD.

Abstract: Systems and methods for telemetric communication between a handheld programmer and an implantable medical device are disclosed. A preferred embodiment comprises a user-friendly, color, touch-sensitive screen that allows the user to visually observe and control the handheld's operation. The handheld further comprises an internal and/or external analytical means to provide robust analytical capabilities. Some embodiments of a system disclosed herein can be configured as a component of an Advanced Patient Management System that helps better monitor, predict and manage chronic diseases.