Patents by Inventor Dennis M. Zimmerman

Dennis M. Zimmerman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-Methyl and N-phenethyl-cis-decahydroisoquinolines
    Patent number: 4219652
    Abstract: 1-Methyl and 1-phenethyl-3a-hydroxy or alkoxy phenyl-cis-decahydroisoquinolines, useful as analgetics.
    Type: Grant
    Filed: September 30, 1975
    Date of Patent: August 26, 1980
    Assignee: Eli Lilly and Company
    Inventors: Dennis M. Zimmerman, Winston S. Marshall
  • N-Alkenyl decahydroisoquinolines
    Patent number: 4208524
    Abstract: 1-Alkenyl-3a-substituted-phenyl decahydroisoquinolines, useful as analgetic agonists or analgetic antagonists.
    Type: Grant
    Filed: May 7, 1974
    Date of Patent: June 17, 1980
    Assignee: Eli Lilly and Company
    Inventors: Dennis M. Zimmerman, Winston S. Marshall
  • Analgesic method using 1,3,4-trisubstituted-4-arylpiperidines
    Patent number: 4191771
    Abstract: 1,3,4-Trisubstituted-4-arylpiperidines are used to impart analgesia and to treat narcotic addiction.
    Type: Grant
    Filed: March 12, 1979
    Date of Patent: March 4, 1980
    Assignee: Eli Lilly and Company
    Inventor: Dennis M. Zimmerman
  • 1,3,4-Trisubstituted-4-aryl-1,4,5,6-tetra-hydropyridines
    Patent number: 4175197
    Abstract: Novel 1,3,4-trisubstituted-4-arylpiperidines are prepared by alkylating a 2,3-disubstituted-3-arylpyrroline to afford a 1,2,3-trisubstituted-3-aryl-1-pyrrolinium salt, reacting the salt with diazomethane to provide a 1,2,3-trisubstituted-3-aryl-1,2-methylene-pyrrolidinium salt, heating the pyrrolidinium salt to effect a ring expansion to the corresponding 1,3,4-trisubstituted-4-aryl-1,4,5,6-tetrahydropyridinium salt, neutralizing the salt and reducing the tetrahydropyridine to provide a 1,3,4-trisubstituted-4-arylpiperidine. The piperidines so formed are useful as pharmacological agents and as intermediates in the preparation of other piperidines of the invention. The compounds provided herein are especially useful as narcotic agonists analgesics and as narcotic antagonists.
    Type: Grant
    Filed: May 12, 1978
    Date of Patent: November 20, 1979
    Assignee: Eli Lilly and Company
    Inventor: Dennis M. Zimmerman
  • Decahydrocyclopent[c]azepines
    Patent number: 4141893
    Abstract: 2-Substituted-5a-aryl-decahydrocyclopent[c]azepines are useful as analgesics having mixed narcotic antagonist and agonist properties.
    Type: Grant
    Filed: November 2, 1976
    Date of Patent: February 27, 1979
    Assignee: Eli Lilly and Company
    Inventor: Dennis M. Zimmerman
  • Trans-5a-aryl-decahydrobenzazepines
    Patent number: 4141894
    Abstract: Trans-5a-phenyl (and substituted phenyl)-N-substituted-2,3,4,5,5a,6,7,8,9,9a-decahydro-1H-2 and 1H-3-benzazepines are useful as analgesic drugs displaying mixed narcotic agonist and antagonist activity.
    Type: Grant
    Filed: November 2, 1976
    Date of Patent: February 27, 1979
    Assignee: Eli Lilly and Company
    Inventor: Dennis M. Zimmerman
  • 1-Azoniabicyclo[3.1.0]hexanes
    Patent number: 4115400
    Abstract: Novel 1,3,4-trisubstituted-4-arylpiperidines are prepared by alkylating a 2,3-disubstituted-3-arylpyrroline to afford a 1,2,3-trisubstituted-3-aryl-1-pyrrolinium salt, reacting the salt with diazomethane to provide a 1,2,3-trisubstituted-3-aryl-1,2-methylene-pyrrolidinium salt, heating the pyrrolidinium salt to effect a ring expansion to the corresponding 1,3,4-trisubstituted-4-aryl-1,4,5,6-tetrahydropyridinium salt, neutralizing the salt and reducing the tetrahydropyridine to provide a 1,3,4-trisubstituted-4-arylpiperidine. The piperidines so formed are useful as pharmacological agents and as intermediates in the preparation of other piperidines of the invention. The compounds provided herein are especially useful as narcotic agonists analgesics and as narcotic antagonists.
    Type: Grant
    Filed: November 17, 1977
    Date of Patent: September 19, 1978
    Assignee: Eli Lilly and Company
    Inventor: Dennis M. Zimmerman
  • Novel cis N-cyclopropylmethyl decahydroisoquinoline
    Patent number: 4100166
    Abstract: Cis-1-cyclopropylmethyl-3a-(substituted-phenyl) decahydroisoquinoline, useful as analgetic agonist and analgetic antagonist.
    Type: Grant
    Filed: October 22, 1976
    Date of Patent: July 11, 1978
    Assignee: Eli Lilly and Company
    Inventors: Dennis M. Zimmerman, Winston S. Marshall
  • 1,3,4-Trisubstituted-4-arylpiperidines and their preparation
    Patent number: 4081450
    Abstract: Novel 1,3,4-trisubstituted-4-arylpiperidines are prepared by alkylating a 2,3-disubstituted-3-arylpyrroline to afford a 1,2,3-trisubstituted-3-aryl-1-pyrrolinium salt, reacting the salt with diazomethane to provide a 1,2,3-trisubstituted-3-aryl-1,2-methylene-pyrrolidinium salt, heating the pyrrolidinium salt to effect a ring expansion to the corresponding 1,3,4-trisubstituted-4-aryl-1,4,5,6-tetrahydropyridinium salt, neutralizing the salt and reducing the tetrahydropyridine to provide a 1,3,4-trisubstituted-4-arylpiperidine. The piperidines so formed are useful as pharmacological agents and as intermediates in the preparation of other piperidines of the invention. The compounds provided herein are especially useful as narcotic agonists analgesics and as narcotic antagonists.
    Type: Grant
    Filed: May 27, 1976
    Date of Patent: March 28, 1978
    Assignee: Eli Lilly and Company
    Inventor: Dennis M. Zimmerman
  • Novel N-cycloalkylmethyl decahydroisoquinolines for producing opiate-like analgesia
    Patent number: 4029796
    Abstract: 1-Cycloalkylmethyl-3a-(substituted-phenyl) decahydroisoquinolines, useful as analgetic agonists or analgetic antagonists.
    Type: Grant
    Filed: September 13, 1976
    Date of Patent: June 14, 1977
    Assignee: Eli Lilly and Company
    Inventors: Dennis M. Zimmerman, Winston S. Marshall
  • 1-Ethyl 3a-(substituted-phenyl) decahydroisoquinoline
    Patent number: 4001247
    Abstract: 1-Ethyl-3a-substituted-phenyl decahydroisoquinolines, useful as an analgetic agonist and analgetic antagonist.
    Type: Grant
    Filed: June 7, 1974
    Date of Patent: January 4, 1977
    Assignee: Eli Lilly and Company
    Inventors: Dennis M. Zimmerman, Winston S. Marshall
  • N-cycloalkylmethyl decahydroisoquinolines
    Patent number: 4001248
    Abstract: 1-Cycloalkylmethyl-3a-(substituted-phenyl) decahydroisoquinolines, useful as analgetic agonists or analgetic antagonists.
    Type: Grant
    Filed: June 7, 1974
    Date of Patent: January 4, 1977
    Assignee: Eli Lilly and Company
    Inventors: Dennis M. Zimmerman, Winston S. Marshall