Abstract: The invention provides dosage forms of a compound of formula 1: or pharmaceutically acceptable salts, solvates or prodrugs thereof. The invention further provides methods of treating hyperproliferative diseases, such as cancers, by administering the dosage forms to a mammal.

Abstract: The invention relates to treatment of cancer in a mammal who has undergone stem cell transplantation by administering an effective amount of a human anti-CTLA-4 antibody to the mammal. Stem cell transplantation may be allogeneic or autologous stem cell transplantation and may be preceded by a preparatory treatment such as chemotherapy. The methods of the invention may be combined with additional cancer treatments. Further, the invention relates to treatment of cancer using at least 10 mg/kg of a human anti-CTLA-4 antibody, and, more preferably, about 15-20 mg/kg of antibody.

Abstract: The invention is directed to methods for the a method for treating overexpression of the erbB2 in a mammal in need of treatment by administering to the mammal a therapeutically effective amount of a first inhibitor of an erbB2 receptor and then, after an interval of less than 24 hours, administering to the mammal from one to six therapeutically effective amounts of the same or different inhibitor of the erbB2 receptor. The invention is also directed to a slow daily infusion of the erbB2 inhibitor. The overexpression of the erbB2 receptor can result in abnormal cell growth and lead to cancer. By the methods of the invention, the efficacy and safety of the inhibitors is increased. The invention is also directed to kits for facilitating the dose administration method of the invention.

Abstract: An all-sided mouthbrush for cleaning a mouth of a user. The all-sided mouthbrush includes a handle including a first end having first and second sides, bristles extending from the first side, and an alternate cleaning device connected to the second side, wherein the bristles clean teeth of the user and the alternate cleaning device cleans a tongue and inner side of the mouth of the user. The alternate cleaning device may be in the form of one of a plurality of parallel ridges, a plurality of columns of tuft-shaped bristles, a plurality of spade headed bristles, a scouring pad-like surface or a plurality of off set rows of bristle-like structures made of soluble crystals for scraping the tongue and inner side of the mouth of the user. A plurality of templates each including a respective alternate cleaning surface and a connecting device for connecting one of the plurality of templates to the second side covering said alternate cleaning device may be attached to the all-sided mouthbrush.