Patents by Inventor Dennis O. Clegg

Dennis O. Clegg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic Supernatant from Cell-Seeded Substrates and Related Methods
    Publication number: 20240049701
    Abstract: Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.
    Type: Application
    Filed: October 10, 2023
    Publication date: February 15, 2024
    Applicants: University of Southern California, The Regents of the University of California
    Inventors: Britney O. Pennington, Jeffrey K. Bailey, Mohamed A. Faynus, Cassidy Arnold, Lincoln V. Johnson, Dennis O. Clegg, Mark S. Humayun, David R. Hinton, Danhong Zhu, Debbie Mitra
  • Cryopreservation of cell-seeded substrates and related methods
    Patent number: 11825839
    Abstract: Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: November 28, 2023
    Assignees: University of Southern California, The Regents of the University of California
    Inventors: Britney O. Pennington, Jeffrey K. Bailey, Mohamed A. Faynus, Cassidy Arnold, Lincoln V. Johnson, Dennis O. Clegg, Mark S. Humayun, David R. Hinton, Danhong Zhu, Debbie Mitra
  • Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same
    Patent number: 11154639
    Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: October 26, 2021
    Assignees: University of Southern California, California Institute of Technology, The Regents of the University of California
    Inventors: Mark S. Humayun, Ashish Ahuja, Yu-Chong Tai, David R. Hinton, Robert H. Grubbs, Dennis O. Clegg, Lincoln Vallance Johnson, Sherry T. Hikita
  • CRYOPRESERVATION OF CELL-SEEDED SUBSTRATES AND RELATED METHODS
    Publication number: 20200077641
    Abstract: Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.
    Type: Application
    Filed: August 30, 2019
    Publication date: March 12, 2020
    Applicants: University of Southern California, The Regents of the University of California
    Inventors: Britney O. Pennington, Jeffrey K. Bailey, Mohamed A. Faynus, Cassidy Arnold, Lincoln V. Johnson, Dennis O. Clegg, Mark S. Humayun, David R. Hinton, Danhong Zhu, Debbie Mitra
  • BIOCOMPATIBLE SUBSTRATE FOR FACILITATING INTERCONNECTIONS BETWEEN STEM CELLS AND TARGET TISSUES AND METHODS FOR IMPLANTING SAME
    Publication number: 20190151499
    Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
    Type: Application
    Filed: December 17, 2018
    Publication date: May 23, 2019
    Applicants: University of Southern California, California Institute of Technology, The Regents of the University of California
    Inventors: Mark S. Humayun, Ashish Ahuja, Yu-Chong Tai, David R. Hinton, Robert H. Grubbs, Dennis O. Clegg, Lincoln Vallance Johnson, Sherry T. Hikita
  • Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same
    Patent number: 10188769
    Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: January 29, 2019
    Assignees: UNIVERSITY OF SOUTHERN CALIFORNIA, CALIFORNIA INSTITUTE OF TECHNOLOGY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Mark S. Humayun, Ashish Ahuja, Yu-Chong Tai, David R. Hinton, Robert H. Grubbs, Dennis O. Clegg, Lincoln Vallance Johnson, Sherry T. Hikita