Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: The present invention is a system and method for automated testing, treatment, and maintenance of fluid such as water disposed in swimming pools, spas, and other bodies of water, wherein the water testing system access a fluid to be monitored by using an in-line T-segment attachment that is inserted into a pipe and that enables a water testing system to be easily attached to the in-line T-segment attachment.

Abstract: The present invention is a system and method for automated testing, treatment, and maintenance of fluid such as water disposed in swimming pools, spas, and other bodies of water, wherein the water testing system includes precise control over the amount of reagent used in testing, and the frequency of testing of any measurable aspect of the test water, wherein the system is optimized for minimal power consumption and reduced complexity of a system for optimized testing and flushing of test water mixed with reagents from a testing reservoir using a fluid flow path system, and the use of fewer moving parts in the fluid flow path to reduce failure and increase the usable life of the water testing system.

Abstract: The present invention is a system and method for automated testing, treatment, and maintenance of fluid such as water disposed in swimming pools, spas, and other bodies of water, wherein the water testing system includes precise control over the amount of reagent used in testing, and the frequency of testing of any measurable aspect of the test water, wherein the system is optimized for minimal power consumption and reduced complexity of a system for optimized testing and flushing of test water mixed with reagents from a testing reservoir using a fluid flow path system, and the use of fewer moving parts in the fluid flow path to reduce failure and increase the usable life of the water testing system.

Abstract: A device particularly suitable for propelling an in-line skater by harnessing the energy of air currents. More particularly, the invention concerns a device which is particularly effective in harnessing and transmitting air current energy to an in-line skater in a controllable, simple, and intuitive manner. The device is simple to construct, rugged and durable, and safer to use than conventional sail devices. The device is easily disassembled and in the disassembled state assists the skater to return to an upwind starting position.