Abstract: Embodiments of the invention provide an injection guide for stabilizing an injection site located on an ocular structure during an intravitreal injection. The injection guide includes a first flange positioned opposite a second flange. The first and second flanges can hold portions of the ocular structure away from the injection site. The injection guide can include a handle coupled to the second flange and positioned away from the injection site to provide a substantially unobstructed view of the injection site and the ocular structure. A base plate can be positioned between and coupled to the first and second flange. The base plate includes an aperture or a notch positioned a predetermined distance from an edge of the base plate to provide 360 degree access to the injection site. The base plate can include a tamponade surface configured to tamponade the ocular structure after the intravitreal injection.