Publication number: 20090098047
Abstract: The present invention is directed to bioconjugates of complexes represented by the formula: wherein R, R?, R1, R?1, R2, R?2, R3, R?3, R4, R?4, R5, R?5, R6, R?6, R7, R?7, R8, R?8, R9, R?9, M, X, Y, Z and n are defined herein for use as contrast agents in diagnostic imaging.
Type:
Application
Filed:
August 4, 2008
Publication date:
April 16, 2009
Applicants:
Inotek Pharmaceuticals, Kereos, Inc.
Inventors:
William L. Neumann, Dennis P. Riley, Randy H. Weiss, Susan L. Henke, Patrick J. Lennon, Karl W. Aston
Patent number: 6525041
Abstract: Low molecular weight mimics of superoxide dismutase (SOD) represented by the formula:
wherein R, R′, R1, R′1, R2, R′2, R3, R′3, R4, R′4, R5, R′5, R6, R′6, R7, R′7, R8, R′8, R9, and R′9, M, X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, and all other conditions of oxidant-induced tissue damage or injury.
Type:
Grant
Filed:
March 14, 1996
Date of Patent:
February 25, 2003
Assignee:
Pharmacia Corporation
Inventors:
William L. Neumann, Dennis P. Riley, Randy H. Weiss, Susan L. Henke, Patrick J. Lennon, Karl W. Aston
Patent number: 6204259
Abstract: The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula:
wherein R, R′, R1, R′1, R2, R′2, R3, R′3, R4, R′4, R5, R′5, R6, R′6, R7, R′7, R8, R′8, R9, R′10, R10 and R′10, X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, myocardial infarction, stroke, atherosclerosis, and all other conditions of oxidant-induced tissue damage or injury.
Type:
Grant
Filed:
January 14, 1993
Date of Patent:
March 20, 2001
Assignee:
Monsanto Company
Inventors:
Dennis P. Riley, Randy H. Weiss, William L. Neumann, Anil S. Modak, Patrick J. Lennon, Karl W. Aston