Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: The present invention relates to a multi-layered composite garment material comprising at least a fabric layer and a functionalized adhesive sheet layer. The present invention also relates to a functionalized adhesive sheet or film comprising 3D adhesive structures embossed on the sheet or film. The sheet or film can be used to bind multiple garment layers while maintaining or enhancing the characteristics of the individual garment layers.

Abstract: The present invention relates to a disc for use in a delivery device for medication units, such as a pills or tablets or portions thereof, comprising a substantially disc-shaped body, comprising means to be engaged for rotation of the disc at least one opening, spaced from the centre of the disc and preferably near the edge of the disc, for holding at least part of the medication unit wherein the at least one opening for holding at least a part of the medication unit is located at a distance from the contour of the disc-shaped body and is thus enclosed by the substantially disc-shaped body.

Abstract: The present invention relates to a medicine unit container for use in a medicine unit delivery device comprising a container body, divided into a number of storeys by means of separating planes; wherein each storey is provided with a rotatable compartment housing, the compartments of which each cover at least a position equidistant in radial direction from a centre of the compartment housing and wherein all compartment housings are rotatable about a central axis extending through their centres and each of the separating planes comprises at least one passage between adjacent storeys, which passage covers the same radial position as the compartments so that there is a rotation angle of a compartment housing in which a compartment is aligned with the passage.

Abstract: The invention relates to a device for packaging of medicine-units, comprising a controllable conveyor for conveying a packaging film extending in a longitudinal direction along a path through the device in a direction of conveyance, a first controllable medicine-unit dispensing device positioned at a first location along the path, at least one second controllable medicine-unit dispensing device, positioned at a second location along the path downstream in the conveying direction relative to the first controllable medicine-unit delivery device, a controller, arranged for controlling the conveyor for moving stepwise in the direction of conveyance and simultaneously controlling the first and at least second dispensing device for dispensing a medicine-unit between displacement steps of the conveyor.

Abstract: The present invention relates to a disc for use in a delivery device for medication units, such as a pills or tablets or portions thereof, comprising a substantially disc-shaped body, comprising means to be engaged for rotation of the disc at least one opening, spaced from the centre of the disc and preferably near the edge of the disc, for holding at least part of the medication unit wherein the at least one opening for holding at least a part of the medication unit is located at a distance from the contour of the disc-shaped body and is thus enclosed by the substantially disc-shaped body.

Abstract: The invention relates to a device for filling a medicine-unit container for use in a medicine unit dispensing device, comprising a support for the container, adapted to fix the position of the container relative to the device and limit a movement of the container relative to the device and at least one movable push element, such as a rod or pin, operable relative to the support, for pushing an unlocking element of a container supported by the device.

Abstract: Roll grooved pipe fittings useful in the assembly of a variety of mechanically joined piping systems. These pipe fittings are roll grooved so that they can be mechanically joined directly with other like pipe fittings and/or with roll grooved straight pipe thereby substantially simplifying assembly. In addition, hybrid pipe fittings and systems are also disclosed. Methods and apparatus for manufacturing these aforementioned roll grooved pipe fittings are also disclosed and address both the roll grooving process itself, as well as various methodology and apparatus for correcting deformations that can occur as a result of the roll grooving process. Methods for using the aforementioned apparatus are also disclosed.

Abstract: A 2-cycle, direct-injection diesel engine configured to accommodate low cetane diesel and jet fuels. The engine includes combustion chambers having surfaces which are operable at high temperatures during engine operation to increase the combustion rate of low cetane fuels. The engine is further configured to reduce starting times in cold and/or low pressure situations such as those experienced during attempts to restart a plane engine at relatively high altitudes.

Abstract: A 2-cycle, direct-injection diesel engine configured to accommodate low cetane diesel and jet fuels. The engine includes combustion chambers having surfaces which are operable at high temperatures during engine operation to increase the combustion rate of low cetane fuels. The engine is further configured to reduce starting times in cold and/or low pressure situations such as those experienced during attempts to restart a plane engine at relatively high altitudes.

Abstract: Roll grooved pipe fittings useful in the assembly of a variety of mechanically joined piping systems. These pipe fittings are roll grooved so that they can be mechanically joined directly with other like pipe fittings and/or with roll grooved straight pipe thereby substantially simplifying assembly. In addition, hybrid pipe fittings and systems are also disclosed. Methods and apparatus for manufacturing these aforementioned roll grooved pipe fittings are also disclosed and address both the roll grooving process itself, as well as various methodology and apparatus for correcting deformations that can occur as a result of the roll grooving process. Methods for using the aforementioned apparatus are also disclosed.

Abstract: A 2-cycle, direct-injection diesel engine configured to accommodate low cetane diesel and jet fuels. The engine includes combustion chambers having surfaces which are operable at high temperatures during engine operation to increase the combustion rate of low cetane fuels. The engine is further configured to reduce starting times in cold and/or low pressure situations such as those experienced during attempts to restart a plane engine at relatively high altitudes.

Abstract: Roll grooved pipe fittings useful in the assembly of a variety of mechanically joined piping systems. These pipe fittings are roll grooved so that they can be mechanically joined directly with other like pipe fittings and/or with roll grooved straight pipe thereby substantially simplifying assembly. In addition, the present disclosure also includes hybrid pipe fittings and systems. Methods and apparatus for manufacturing these aforementioned roll grooved pipe fittings address both the roll grooving process itself, as well as various methodology and apparatus for correcting deformations that can occur as a result of the roll grooving process. The present disclosure also includes methods for using the aforementioned apparatus.

Abstract: A 2-cycle, direct-injection diesel engine configured to accommodate low cetane diesel and jet fuels. The engine includes combustion chambers having surfaces which are operable at high temperatures during engine operation to increase the combustion rate of low cetane fuels. The engine is further configured to reduce starting times in cold and/or low pressure situations such as those experienced during attempts to restart a plane engine at relatively high altitudes.

Abstract: A 2-cycle, direct-injection diesel engine configured to accommodate low cetane diesel and jet fuels. The engine includes combustion chambers having surfaces which are operable at high temperatures during engine operation to increase the combustion rate of low cetane fuels. The engine is further configured to reduce starting times in cold and/or low pressure situations such as those experienced during attempts to restart a plane engine at relatively high altitudes.

Abstract: A method and an apparatus for using a plurality of antennas to equalize a composite propagation channel of a wideband wireless communication is provided. The method comprises adjusting a corresponding weight associated with at least two of the plurality of antennas to obtain a channel response from the plurality of antennas over a composite propagation channel. The method further comprises equalizing the channel response of the composite propagation channel over a given bandwidth based on the corresponding weights for the wireless communication over a wideband frequency range. By adjusting a complex weight associated with each of the set of transmit antennas, a wireless communication system may obtain a channel response from the plurality of antennas over the composite propagation channel.

Abstract: A system and apparatus are described for providing greater flexibility and performance in a mixed-signal array through improved and highly configurable routing, control elements and signal processing capabilities.

Abstract: Techniques for computer-assisted routing of an electronic design for a programmable target device are described herein. In an example embodiment, a computer system displays a representation of the programmable target device in a user interface. The computer system receives first user input that indicates a first component in the electronic design for the programmable target device. The computer system determines one or more second components of the electronic design that can be routed to the first component and displays one or more visual objects that indicate the one or more second components. The computer system then receives second user input that selects a particular component from the one or more second components and stores interconnect data indicating that the first component is routed to the particular component.

Abstract: An endpoint or other communication device of a communication system includes a clock recovery module. The communication device is operative as a slave device relative to another communication device that is operative as a master device. The clock recovery module comprises a clock recovery loop configured to control a slave clock frequency of the slave device so as to synchronize the slave clock frequency with a master clock frequency of the master device. The clock recovery loop utilizes a frequency error estimator implemented as a maximum-likelihood estimator with slope fitting based on a sequence of arrival timestamps, and a loop filter implemented as a series combination of an adaptive-bandwidth filter and a proportional-integral controller.

Abstract: An endpoint or other communication device of a communication system includes a clock recovery module. The communication device is operative as a slave device relative to another communication device that is operative as a master device. The clock recovery module comprises a clock recovery loop configured to control a slave clock frequency of the slave device so as to synchronize the slave clock frequency with a master clock frequency of the master device. The clock recovery loop comprises a primary loop having a first frequency error estimator for generating a first estimate of error between the master and slave clock frequencies, a second frequency error estimator outside of the primary loop for generating a second estimate of error between the master and slave clock frequencies, and an accumulator coupled between the second frequency error estimator and the primary loop. The second estimate is controllably injected into the primary loop via the accumulator.