Patents by Inventor Dennis Sousa
Dennis Sousa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240397937Abstract: The disclosure provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the disclosure relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes, for example, a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate, for example, the: 1) overall perfusion status of an isolated heart; 2) metabolic status of an isolated heart; and 3) overall vascular patency of an isolated donor heart. This aspect of the present disclosure may use, for example, the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.Type: ApplicationFiled: May 7, 2024Publication date: December 5, 2024Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Ahmed ELBETANONY, Paul LEZBERG, Giovanni CECERE, Dennis SOUSA, Elizabeth Hansen BULGER
-
Patent number: 12010987Abstract: The disclosure provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the disclosure relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes, for example, a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate, for example, the: 1) overall perfusion status of an isolated heart; 2) metabolic status of an isolated heart; and 3) overall vascular patency of an isolated donor heart. This aspect of the present disclosure may use, for example, the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.Type: GrantFiled: January 12, 2023Date of Patent: June 18, 2024Assignee: TRANSMEDICS, INC.Inventors: Waleed H. Hassanein, Tamer I. Khayal, Ahmed Elbetanony, Paul Lezberg, Giovanni Cecere, Dennis Sousa, Elizabeth Hansen Bulger
-
Publication number: 20230210104Abstract: The disclosure provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the disclosure relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes, for example, a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate, for example, the: 1) overall perfusion status of an isolated heart; 2) metabolic status of an isolated heart; and 3) overall vascular patency of an isolated donor heart. This aspect of the present disclosure may use, for example, the property of myocardial cell’s unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.Type: ApplicationFiled: January 12, 2023Publication date: July 6, 2023Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Ahmed ELBETANONY, Paul LEZBERG, Giovanni CECERE, Dennis SOUSA, Elizabeth Hansen BULGER
-
Patent number: 11570985Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.Type: GrantFiled: June 30, 2020Date of Patent: February 7, 2023Assignee: TRANSMEDICS, INC.Inventors: Waleed H. Hassanein, Tamer I. Khayal, Ahmed Elbetanony, Paul Lezberg, Giovanni Cecere, Dennis Sousa, Elizabeth Hansen Bulger
-
Publication number: 20200337298Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.Type: ApplicationFiled: June 30, 2020Publication date: October 29, 2020Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Ahmed ELBETANONY, Paul LEZBERG, Giovanni CECERE, Dennis SOUSA, Elizabeth (Hansen) BULGER
-
Patent number: 10736314Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.Type: GrantFiled: April 26, 2019Date of Patent: August 11, 2020Assignee: TRANSMEDICS, INC.Inventors: Waleed H. Hassanein, Tamer I. Khayal, Ahmed Elbetanony, Paul Lezberg, Giovanni Cecere, Dennis Sousa, Elizabeth (Hansen) Bulger
-
Publication number: 20190261626Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.Type: ApplicationFiled: April 26, 2019Publication date: August 29, 2019Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Ahmed ELBETANONY, Paul LEZBERG, Giovanni CECERE, Dennis SOUSA, Elizabeth (Hansen) BULGER
-
Patent number: 10321676Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.Type: GrantFiled: December 29, 2017Date of Patent: June 18, 2019Assignee: TRANSMEDICS, INC.Inventors: Waleed H. Hassanein, Tamer I. Khayal, Ahmed Elbetanony, Paul Lezberg, Giovanni Cecere, Dennis Sousa, Elizabeth Hansen Bulger
-
Publication number: 20180153158Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.Type: ApplicationFiled: December 29, 2017Publication date: June 7, 2018Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Ahmed ELBETANONY, Paul LEZBERG, Giovanni CECERE, Dennis SOUSA, Elizabeth HANSEN
-
Patent number: 9894894Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.Type: GrantFiled: August 16, 2012Date of Patent: February 20, 2018Assignee: TRANSMEDICS, INC.Inventors: Waleed Hassanein, Tamer Khayal, Ahmed Elbetanony, Paul Lezberg, Giovanni Cecere, Dennis Sousa, Elizabeth Hansen
-
Patent number: 9301519Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.Type: GrantFiled: October 7, 2005Date of Patent: April 5, 2016Assignee: TRANSMEDICS, INC.Inventors: Waleed Hassanein, Richard Bringham, Giovanni Cecere, Ahmed Elbetanony, Robert Fishman, Larry Goff, Tamer Khayal, Stanley Kyi, Scott Newell, Burt Ochs, Dennis Sousa, Ronald Taylor, Jonathan Rourke, Hossam Algamil, David Carpenter, Robert Havner
-
Patent number: 8465970Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.Type: GrantFiled: October 7, 2005Date of Patent: June 18, 2013Assignee: TransMedics, Inc.Inventors: Waleed Hassanein, Richard Bringham, Giovanni Cecere, Ahmed Elbetanony, Robert Fishman, Larry Goff, Tamer Khayal, Stanley Kyi, Scott Newell, Burt Ochs, Dennis Sousa, Ronald Taylor, Jonathan Rourke, Hossam Algamil, David Carpenter, Robert Havner, Dmitri Menn
-
Publication number: 20130078710Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.Type: ApplicationFiled: August 16, 2012Publication date: March 28, 2013Applicant: TRANSMEDICS, INCInventors: Waleed HASSANEIN, Tamer KHAYAL, Ahmed ELBETANONY, Paul LEZBERG, Giovanni CECERE, Dennis SOUSA, Elizabeth HANSEN
-
Patent number: 8304181Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.Type: GrantFiled: April 25, 2007Date of Patent: November 6, 2012Assignee: Transmedics, Inc.Inventors: Waleed Hassanein, Tamer Khayal, Ahmed Elbetanony, Paul Lezberg, Giovanni Cecere, Dennis Sousa, Elizabeth Hansen
-
Publication number: 20070275364Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.Type: ApplicationFiled: April 25, 2007Publication date: November 29, 2007Inventors: Waleed Hassanein, Tamer Khayal, Ahmed Elbetanony, Paul Lezberg, Giovanni Cecere, Dennis Sousa, Elizabeth Hansen
-
Publication number: 20060154357Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.Type: ApplicationFiled: October 7, 2005Publication date: July 13, 2006Applicant: TRANSMEDICS, INC.Inventors: Waleed Hassanein, Richard Bringham, Giovanni Cecere, Ahmed Elbetanony, Robert Fishman, Larry Goff, Tamer Khayal, Stanley Kyi, Scott Newell, Burt Ochs, Dennis Sousa, Ronald Taylor, Jonathan Rourke, Hossam Algamil, David Carpenter, Robert Havner, Dmitri Menn
-
Publication number: 20060154358Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.Type: ApplicationFiled: October 7, 2005Publication date: July 13, 2006Applicant: TransMedics, Inc.Inventors: Waleed Hassanein, Richard Bringham, Giovanni Cecere, Ahmed Elbetanony, Robert Fishman, Larry Goff, Tamer Khayal, Stanley Kyi, Scott Newell, Burt Ochs, Dennis Sousa, Ronald Taylor, Jonathan Rourke, Hossam Algamil, David Carpenter, Robert Havner, Dmitri Menn