Patents by Inventor Dennis T. Drayna

Dennis T. Drayna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Plasma carboxypeptidase
    Patent number: 5364934
    Abstract: A novel polypeptide, designated plasma carboxypeptidase B (PCPB), has been purified from human plasma. It has been cloned from a human liver cDNA library using PCR amplification. Provided herein is nucleic acid encoding PCPB useful in diagnostics and in the recombinant preparation of PCPB. PCPB is used in the preparation and purification of antibodies thereto, in the purification of plasminogen, in the inhibition of plasminogen activation by t-PA in the presence of fibrinogen, and in diagnostic assays.
    Type: Grant
    Filed: December 15, 1993
    Date of Patent: November 15, 1994
    Assignee: Genentech, Inc.
    Inventors: Dennis T. Drayna, Dan L. Eaton
  • Human plasma carboxypeptidase B
    Patent number: 5206161
    Abstract: A novel polypeptide, designated plasma carboxypeptidase B (PCPB), has been purified from human plasma. It has been cloned from a human liver cDNA library using PCR amplification. Provided herein is nucleic acid encoding PCPB useful in diagnostics and in the recombinant preparation of PCPB. PCPB is used in the preparation and purification of antibodies thereto, in the purification of plasminogen, in the inhibition of plasminogen activation by t-PA in the presence of fibrinogen, and in diagnostic assays.
    Type: Grant
    Filed: February 1, 1991
    Date of Patent: April 27, 1993
    Assignee: Genentech, Inc.
    Inventors: Dennis T. Drayna, Dan L. Eaton
  • Method and nucleic acid for the preparation of lecithin:cholesterol acyltransferase
    Patent number: 5049488
    Abstract: Nucleic acid encoding lecithin:cholesterol acyltransferase is ligated into expression vectors and used to transform host cells for the synthesis of lecithin:cholesterol acyltransferase in recombinant cell culture. Lecithin:cholesterol acyltransferase amino acid sequence variants are described for enhancing the properties of lecithin:cholesterol acyltransferase. Lecithin:cholesterol acyltransferase and its variants are employed in the therapy of conditions characterized by hypercholesterolemia and for the mobilization of cholesterol in vivo.
    Type: Grant
    Filed: November 8, 1985
    Date of Patent: September 17, 1991
    Assignee: Genentech, Inc.
    Inventors: Bradford W. Baer, Dennis T. Drayna, Richard M. Lawn, John W. McLean