Patents by Inventor Dennis Wetzl

Dennis Wetzl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESSES FOR MAKING BICYCLIC KETONE COMPOUNDS
    Publication number: 20240034739
    Abstract: Processes are provided herein for the preparation of a bicyclic ketone compound of formula (I), or a stereoisomer thereof: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and n are as defined herein; and compounds prepared by these processes.
    Type: Application
    Filed: October 2, 2023
    Publication date: February 1, 2024
    Applicants: Genentech, Inc., Hoffmann-La Roche Inc.
    Inventors: Allen Yu HONG, Nicholas WONG, Sean M. KELLY, Lauren Elizabeth SIROIS, Sara SCHWEGLER, Xin LINGHU, Francis GOSSELIN, Katarzyna Aleksandra PIECHOWICZ, Carmela MOLINARO, Dennis WETZL
  • Process for the Preparation of a Chiral Piperazine-2-carboxylic Acid
    Publication number: 20230175026
    Abstract: The invention relates to a novel process for the preparation of a chiral piperazine-2- carboxylic acid or of a salt thereof of the formula (I). The chiral piperazine-2-carboxylic acid derivatives of the formula (I) are key intermediates for the preparation of fused heteroaryl dihydro pyrimidines which are useful for the treatment and prophylaxis of hepatitis B virus infections.
    Type: Application
    Filed: April 26, 2021
    Publication date: June 8, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joséphine Eliette Françoise CINQUALBRE, Stefan HILDBRAND, Paolo TOSATTI, Kurt PUENTENER, Dennis WETZL, Hans IDING, Patrick STOCKER, Nicolas Mickael FÉDOU, Paul SPURR
  • Proline hydroxylases as well as uses, methods and products involving the same
    Patent number: 10968469
    Abstract: The present invention relates to the use of a protein as a hydroxylase, a host cell comprising the protein, the use of the protein or host cell in the production of hydroxy-pipecolic acid (HPA), a method of production HPA, methods of producing the protein, a mutant protein and a nucleic acid encoding the mutant protein and a vector comprising a nucleic acid encoding the protein.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: April 6, 2021
    Assignee: F. Hoffmann-La Roche, Inc.
    Inventors: Mara Boenitz-Dulat, Hans Iding, Dennis Wetzl, Alessa Hinzmann
  • PROLINE HYDROXYLASES AS WELL AS USES, METHODS AND PRODUCTS INVOLVING THE SAME
    Publication number: 20190153491
    Abstract: The present invention relates to the use of a protein as a hydroxylase, a host cell comprising the protein, the use of the protein or host cell in the production of hydroxy-pipecolic acid (HPA), a method of production HPA, methods of producing the protein, a mutant protein and a nucleic acid encoding the mutant protein and a vector comprising a nucleic acid encoding the protein.
    Type: Application
    Filed: November 21, 2018
    Publication date: May 23, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Mara Boenitz-Dulat, Hans Iding, Dennis Wetzl, Alessa Hinzmann