Patents by Inventor Dennis William Powell

Dennis William Powell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anilino-pyrimidine analogs
    Patent number: 7799915
    Abstract: The present invention relates to compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are defined herein.
    Type: Grant
    Filed: October 13, 2005
    Date of Patent: September 21, 2010
    Assignee: Wyeth LLC
    Inventors: Fuk-Wah Sum, Dennis William Powell, Yixian Zhang, Lijing Chen, Scott Lee Kincaid, Lee Dalton Jennings, Yongbo Hu, Adam Matthew Gilbert, Matthew Gregory Bursavich
  • 3-Quinolinecarbonitrile protein kinase inhibitors
    Patent number: 7767671
    Abstract: This invention provides a compound of Formula 1 where Ar, X, R1, R2, R3, and R4 are defined herein, or a pharmaceutically acceptable salt thereof useful in the prevention or inhibition of diseases associated with the Ras/Raf/MEK signaling cascade in a mammal, such as neoplasms, strokes, osteoporosis, cancer, rheumatoid arthritis, inflammatory disease, polycystic kidney disease, and colonic polyps, and methods of making the compounds of formula 1 and intermediates.
    Type: Grant
    Filed: September 23, 2008
    Date of Patent: August 3, 2010
    Assignee: Wyeth
    Inventors: Dan Maarten Berger, Dennis William Powell, Biqi Wu
  • 3-QUINOLINECARBONITRILE PROTEIN KINASE INHIBITORS
    Publication number: 20090062281
    Abstract: This invention provides a compound of Formula 1 where Ar, X, R1, R2, R3, and R4 are defined herein, or a pharmaceutically acceptable salt thereof useful in the prevention or inhibition of diseases associated with the Ras/Raf/MEK signaling cascade in a mammal, such as neoplasms, strokes, osteoporosis, cancer, rheumatoid arthritis, inflammatory disease, polycystic kidney disease, and colonic polyps, and methods of making the compounds of formula 1 and intermediates.
    Type: Application
    Filed: September 23, 2008
    Publication date: March 5, 2009
    Applicant: Wyeth
    Inventors: Dan Maarten Berger, Dennis William Powell, Biqi Wu
  • 3-Quinolinecarbonitrile protein kinase inhibitors
    Patent number: 7449460
    Abstract: This invention provides a compound of Formula 1 where Ar, X, R1, R2, R3, and R4 are defined herein, or a pharmaceutically acceptable salt thereof useful in the prevention or inhibition of diseases associated with the Ras/Raf/MEK signaling cascade in a mammal, such as neoplasms, strokes, osteoporosis, cancer, rheumatoid arthritis, inflammatory disease, polycystic kidney disease, and colonic polyps, and methods of making the compounds of formula 1 and intermediates.
    Type: Grant
    Filed: February 16, 2005
    Date of Patent: November 11, 2008
    Assignee: Wyeth
    Inventors: Dan Maarten Berger, Dennis William Powell, Biqi Wu
  • 4,6-diamino-[1,7]naphthyridine-3-carbonitrile inhibitors of Tpl2 kinase and methods of making and using the same
    Patent number: 7432279
    Abstract: The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5r6, m and n are defined as described herein. The invention also provides methods of making the compounds of formula (I), and methods of treating inflammatory diseases, such as rheumatoid arthritis, in a mammal comprising administering a therapeutically effective amount of a compound of formula (I) to the mammal.
    Type: Grant
    Filed: May 18, 2006
    Date of Patent: October 7, 2008
    Assignee: Wyeth
    Inventors: Neal Jeffrey Green, Lori Krim Gavrin, Neelu Kaila, Yonghan Hu, Kristin Marie Janz, Jennifer R. Thomason, Ariamala Gopalsamy, Steve Y. Tam, Lih-Ling Lin, John William Cuozzo, Dennis William Powell
  • 3-Cyanoquinolines,3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
    Publication number: 20040176602
    Abstract: This invention provides compounds of Formula (I), having the structure 1
    Type: Application
    Filed: January 9, 2004
    Publication date: September 9, 2004
    Applicant: Wyeth
    Inventors: Diane Harris Boschelli, Yanong Wang, Frank Charles Boschelli, Dan Maarten Berger, Nan Zhang, Dennis William Powell, Fei Ye, Ayako Yamashita, Frenel Fils DeMorin, Biqi Wu, Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
  • 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
    Patent number: 6689772
    Abstract: This invention provides compounds of Formula (I), having the structure where T, Z, X, A, R1, R2a, R2b, R2c, R3, R4, and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: February 10, 2004
    Assignee: Wyeth
    Inventors: Diane Harris Boschelli, Yanong Wang, Frank Charles Boschelli, Dan Maarten Berger, Nan Zhang, Dennis William Powell, Fei Ye, Ayako Yamashita, Frenel Fils DeMorin, Biqi Wu, Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
  • 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
    Patent number: 6521618
    Abstract: This invention provides compounds of Formula (I), having the structure where T, Z, X, A, R1, R2a, R2b, R2c, R3, R4, and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: February 18, 2003
    Assignee: Wyeth
    Inventors: Diane Harris Boschelli, Yanong Wang, Frank Charles Boschelli, Dan Maarten Berger, Nan Zhang, Dennis William Powell, Fei Ye, Ayako Yamashita, Frenel Fils DeMorin, Biqi Wu, Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
  • 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
    Publication number: 20020026052
    Abstract: This invention provides compounds of Formula (I), having the structure 1
    Type: Application
    Filed: March 28, 2001
    Publication date: February 28, 2002
    Applicant: American Home Products Corporation
    Inventors: Diane Harris Boschelli, Yanong Wang, Frank Charles Boschelli, Dan Maarten Berger, Nan Zhang, Dennis William Powell, Fei Ye, Ayako Yamashita, Frenel Fils Demorin, Biqi Wu, Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
  • Substituted dibenzothiophenes having antiangiogenic activity
    Patent number: 6022307
    Abstract: The invention provides novel substituted dibenzothiophenes of Formulae (I), (II), (III) and (IV) which have antiangiogenic activity and further provides a method using substituted dibenzothiophenes of Formula (V) as antiangiogenic agents.
    Type: Grant
    Filed: June 28, 1999
    Date of Patent: February 8, 2000
    Assignee: American Cyanamid Company
    Inventors: Mark E. Salvati, Nancy H. Eudy, William A. Hallett, Dennis William Powell