Abstract: A valve for an air brake system on a commercial vehicle comprises a body, an inlet port connected to the body and at least one delivery port connected to the body. The inlet port has a threaded portion distal to the body and a hex portion proximate to the body. The hex portion includes a frangible feature in substantially the mid-point of the hex portion such that the valve can easily be removed from an air brake reservoir when the valve is broken at the frangible feature.

Abstract: A sensor apparatus for detecting a target object influenced by a process or formed in the process includes a sensor unit and an evaluation device. The sensor unit detects the target object in a detection zone of the sensor unit and generates a sensor signal that can be influenced by the target object. The evaluation device processes the sensor signal as a first input variable and generates an output signal, which indicates the detection of the target object, in dependence on the sensor signal. The evaluation device further processes a process parameter of the process, which acts on the target object, or a target object parameter, which characterizes the target object and is influenced by the process, as a respective further input variable and to generate the output signal in dependence on the process parameter and/or the target object parameter.

Abstract: A method and machine for cutting and removing a workpiece part from a plate-shaped material includes cutting the workpiece part with a beam or jet directed onto the material and separating the workpiece part and material. The workpiece part is removed as a scrap skeleton removal part. The cut-free workpiece part is lifted out of a workpiece supporting plane by a lifting device and removed by a gripping device, or the cut-free workpiece part is removed downwards from the plane through a gap between workpiece supporting surfaces by an ejection device, or gravity removes the cut-free workpiece part downwards through the gap. Before cutting the workpiece part free, a sacrificial part adjoining the workpiece part and partially having a common cutting line with the workpiece part is cut free from the material before cutting the workpiece part free in the material or scrap skeleton.

Abstract: A method for producing workpiece parts from a plate-shaped workpiece in a processing machine or laser processing machine includes positioning and holding the workpiece on a workpiece support by clamping devices. A plurality of workpiece parts are cut out of the workpiece with a process beam. The process beam is moved relative to the workpiece support by a processing head and/or the workpiece is moved relative to the workpiece support by the clamping devices. A cutting process for processing the workpiece to produce the workpiece parts is interrupted at least once by a relaxation step for the workpiece. During the relaxation step at least one clamping device is released to relax the workpiece. The at least one clamping device is closed following the relaxation and before continuing the cutting process. A data processing program and a processing machine for producing the workpiece parts are also provided.

Abstract: A machine for separative machining of a plate-shaped workpiece that has: a first movement unit for moving the workpiece in a first direction (X); a second movement unit for moving a machining head for the separative machining in a second direction (Y); and two workpiece bearing faces for bearing the workpiece. A gap that extends along the second direction (Y) is formed between the workpiece bearing faces. The machine has a push-out unit having a push-out element, wherein the push-out element is movable at least in the second direction (Y) within the gap so as to press, at a predefined push-out position (AP), against a workpiece part that was cut free from the workpiece during separative machining. The disclosure further relates to methods for pushing out a workpiece part which, in particular, was cut free on such a machine.

Abstract: A method for transporting workpiece parts out of a cutting area of a laser cutting machine includes: moving a first holding device for holding workpiece parts along a first guide in a transporting direction transverse to a direction of movement of a laser cutting head, and moving a second holding device along a second guide in the transporting direction transverse to the direction of movement of the laser cutting head. First workpiece parts, which are cut within the cutting area from a first half of a workpiece, are transported from the cutting area into the storage area by the first holding device. Second workpiece parts, which are cut within the cutting area from a second half of the workpiece, are transported from the cutting area into storage area by the second holding device. The transportation of the first and second workpiece parts takes place in alternation.

Abstract: A spring wire which can be cold formed well at diameters of at least 9 mm, but has improved mechanical properties. The spring wire is manufactured from a steel including, in % by weight, C: 0.35-0.42%, Si: 1.5-1.8%, Mn: 0.5-0.8%, Cr: 0.05-0.25%, Nb: 0.020-0.10%, V: 0.020-0.10%, N: 0.0040-0.0120%, Al: ?0.03% and as the remainder iron and unavoidable impurities, wherein the total content of impurities is limited to at most 0.2% and the impurities include up to 0.025% P and up to 0.025% S. The spring wire is in particular suitable for the manufacture of a tension clamp with optimized usage properties. Also, a method which enables the practice-oriented production of the spring wire.

Abstract: A method for cutting a workpiece includes cutting the workpiece along a predefined cutting contour to separate a workpiece part from a scrap part, and checking whether the workpiece part has been fully separated from the scrap part during the cutting. The workpiece is re-cut along an additional cutting contour laterally offset from the predefined cutting contour if it is found during the checking that the workpiece part has not been fully separated from the scrap part. The disclosure also relates to an associated machine for cutting a workpiece.

Abstract: A sensor apparatus for detecting a target object influenced by a process or formed in the process includes a sensor unit and an evaluation device. The sensor unit detects the target object in a detection zone of the sensor unit and generates a sensor signal that can be influenced by the target object. The evaluation device processes the sensor signal as a first input variable and generates an output signal, which indicates the detection of the target object, in dependence on the sensor signal. The evaluation device further processes a process parameter of the process, which acts on the target object, or a target object parameter, which characterizes the target object and is influenced by the process, as a respective further input variable and to generate the output signal in dependence on the process parameter and/or the target object parameter.

Abstract: The invention relates to machines and methods for separative machining of plate-shaped workpieces by a processing beam. The machines include a first movement unit configured to move the workpiece in a first direction and a second movement unit including a machining head configured to emit the processing beam. The second movement unit is configured to move the machining head in a second direction perpendicular to the first direction to direct the processing beam onto the workpiece. The machines include a first workpiece support unit including a first workpiece-bearing face and a second workpiece support unit including a second workpiece-bearing face spaced apart by a gap from the first workpiece support unit and the first workpiece-bearing face. The gap extends along the second direction. The machines include at least one support slide arranged to move in the second direction within the gap and including a support slide bearing face.

Abstract: A valve for an air brake system on a commercial vehicle comprises a body, an inlet port connected to the body and at least one delivery port connected to the body. The inlet port has a threaded portion distal to the body and a hex portion proximate to the body. The hex portion includes a frangible feature in substantially the mid-point of the hex portion such that the valve can easily be removed from an air brake reservoir when the valve is broken at the frangible feature.

Abstract: A method for removing a workpiece from the remainder of the workpiece supported in a bearing plane. The method includes moving the workpiece part, which is clamped between at least one ejector element of an ejection unit and at least one counter-holding element of a counter-holding unit, along a removal direction, and checking whether the workpiece part has been completely separated from the remainder of the workpiece during movement along the removal direction. The method is characterized by reducing or completely canceling the clamping of the workpiece part and subsequently resuming the clamping of the workpiece part if it is determined during checking that the workpiece part has not been completely separated from the remainder of the workpiece.

Abstract: The present invention provides an isolated monoclonal antibody or an antigen-binding portion thereof which a) binds to Mac-1, b) specifically inhibits the interaction of CD40L with activated Mac-1 and c) does not induce integrin outside-in signaling.

Abstract: The CD40L/Mac-1 interaction is selectively targeted by small peptide inhibitors and/or antibodies and such peptides are used for the specific treatment of inflammation and atherogenesis. In particular, pharmaceutical compositions comprising a polypeptide having the amino acid sequence EQLKKSKTL and antibodies specifically binding to an epitope are disclosed.

Abstract: A method for cutting a workpiece includes cutting the workpiece along a predefined cutting contour to separate a workpiece part from a scrap part, and checking whether the workpiece part has been fully separated from the scrap part during the cutting. The workpiece is re-cut along an additional cutting contour laterally offset from the predefined cutting contour if it is found during the checking that the workpiece part has not been fully separated from the scrap part. The disclosure also relates to an associated machine for cutting a workpiece.

Abstract: The present invention provides an isolated monoclonal antibody or an antigen-binding portion thereof which a) binds to Mac-1, b) specifically inhibits the interaction of CD40L with activated Mac-1 and c) does not induce integrin outside-in signaling.

Abstract: A method for cutting a workpiece includes cutting the workpiece along a predefined cutting contour to separate a workpiece part from a scrap part, and checking whether the workpiece part has been fully separated from the scrap part during the cutting. The workpiece is re-cut along an additional cutting contour laterally offset from the predefined cutting contour if it is found during the checking that the workpiece part has not been fully separated from the scrap part. The disclosure also relates to an associated machine for cutting a workpiece.

Abstract: The CD40L/Mac-1 interaction is selectively targeted by small peptide inhibitors and/or antibodies and such peptides are used for the specific treatment of inflammation and atherogenesis. In particular, pharmaceutical compositions comprising a polypeptide having the amino acid sequence EQLKKSKTL and antibodies specifically binding to an epitope are disclosed.

Abstract: A method for cutting a workpiece includes cutting the workpiece along a predefined cutting contour to separate a workpiece part from a scrap part, and checking whether the workpiece part has been fully separated from the scrap part during the cutting. The workpiece is re-cut along an additional cutting contour laterally offset from the predefined cutting contour if it is found during the checking that the workpiece part has not been fully separated from the scrap part. The disclosure also relates to an associated machine for cutting a workpiece.

Abstract: The present invention provides an isolated monoclonal antibody or an antigen-binding portion thereof which a) binds to Mac-1, b) specifically inhibits the interaction of CD40L with activated Mac-1 and c) does not induce integrin outside-in signaling.