Patents by Inventor Dennis Y. Lee
Dennis Y. Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210379290Abstract: A syringe includes a barrel, a plunger, and a sealing member creating a seal between the plunger and the barrel. The barrel includes a first portion with a first inner diameter and a second portion with a second inner diameter that is larger than the first inner diameter. The sealing member engages the first portion of the barrel to give rise to a first contact pressure when the barrel is filled with product. The first contact pressure is sufficient to maintain a gas-tight seal over the expected temperature ranges ?25° C. to 40° C. A first force is applied to the plunger to overcome the first contact pressure and move the plunger out of the first portion and into the second portion to dispense product. The sealing member engages the second portion of the barrel to give rise to a second contact pressure that is lower than the first contact pressure.Type: ApplicationFiled: January 15, 2021Publication date: December 9, 2021Inventors: Sean E. Mackey, Ji Zhou, Martin J. Gibler, Dennis Y. Lee
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Patent number: 10869745Abstract: The present disclosure relates to tissue matrix products. The products can include tissue matrices that have openings such as holes or perforations located at certain positions to improve various functions without substantial loss of strength or other important properties. The openings can facilitate implantation of the tissue matrices in surgical procedures thereby speeding operation times and potentially improving surgical results.Type: GrantFiled: October 4, 2017Date of Patent: December 22, 2020Assignee: LifeCell CorporationInventors: Dennis Y. Lee, Jennifer Lynn Steinkoenig, Israel James Jessop, Alexander Ringo
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COMPOSITE TISSUE PRODUCT ANCHOR BOLSTER FOR THREE-DIMENSIONAL BIOLOGIC SCAFFOLDS AND RELATED METHODS
Publication number: 20200315776Abstract: The present disclosure provides anchor bolsters for three-dimensional biologic scaffolds, including related methods of formation and use. The composite bolster-scaffold provides an improved device to securely anchor a three-dimensional tissue scaffold in position relative to surrounding anatomic structures, allowing time for colonization of native cells and subsequent incorporation of the three-dimensional tissue scaffold by the recipient tissue bed.Type: ApplicationFiled: April 7, 2020Publication date: October 8, 2020Inventor: Dennis Y. Lee -
Patent number: 10792394Abstract: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating select portions of a tissue matrix with a fluid containing at least one agent to produce a tissue matrix with variable mechanical and/or biological properties.Type: GrantFiled: May 26, 2017Date of Patent: October 6, 2020Assignee: LIFECELL CORPORATIONInventors: Ming F. Pomerleau, Hua Wan, Hui Xu, Dennis Y. Lee
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Publication number: 20190117202Abstract: Devices, systems, and methods for tissue transfer are disclosed that can allow control of transfer speed. The devices use positive and negative pressure to advance a plunger (322) into or out of a body (311) of the device. A pressure regulator may be used to control the applied pressure. Maintaining transfer speed within acceptable ranges and/or controlling pressure or shear forces on tissues can improve the viability of certain types of tissue.Type: ApplicationFiled: November 1, 2016Publication date: April 25, 2019Applicant: LifeCell CorporationInventors: Kai-Roy Wang, Christopher Locke, Dennis Y. Lee, Evan J. Friedman, Israel Jessop, Sangwook Park
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Publication number: 20180098836Abstract: The present disclosure relates to tissue matrix products. The products can include tissue matrices that have openings such as holes or perforations located at certain positions to improve various functions without substantial loss of strength or other important properties. The openings can facilitate implantation of the tissue matrices in surgical procedures thereby speeding operation times and potentially improving surgical results.Type: ApplicationFiled: October 4, 2017Publication date: April 12, 2018Inventors: Dennis Y. Lee, Jennifer Lynn Steinkoenig, Israel James Jessop, Alexander Ringo
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Publication number: 20170348460Abstract: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided.Type: ApplicationFiled: May 26, 2017Publication date: December 7, 2017Inventors: Ming Fang, Hua Wan, Hui Xu, Dennis Y. Lee
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Publication number: 20170189620Abstract: A syringe includes a barrel, a plunger, and a sealing member creating a seal between the plunger and the barrel. The barrel includes a first portion with a first inner diameter and a second portion with a second inner diameter that is larger than the first inner diameter. The sealing member engages the first portion of the barrel to give rise to a first contact pressure when the barrel is filled with product. The first contact pressure is sufficient to maintain a gas-tight seal over the expected temperature ranges ?25° C. to 40° C. A first force is applied to the plunger to overcome the first contact pressure and move the plunger out of the first portion and into the second portion to dispense product. The sealing member engages the second portion of the barrel to give rise to a second contact pressure that is lower than the first contact pressure.Type: ApplicationFiled: March 17, 2017Publication date: July 6, 2017Inventors: Sean E. Mackey, Ji Zhou, Martin J. Gibler, Dennis Y. Lee
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Patent number: 9669165Abstract: A syringe includes a barrel, a plunger, and a sealing member creating a seal between the plunger and the barrel. The barrel includes a first portion with a first inner diameter and a second portion with a second inner diameter that is larger than the first inner diameter. The sealing member engages the first portion of the barrel to give rise to a first contact pressure when the barrel is filled with product. The first contact pressure is sufficient to maintain a gas-tight seal over the expected temperature ranges ?25° C. to 40° C. A first force is applied to the plunger to overcome the first contact pressure and move the plunger out of the first portion and into the second portion to dispense product. The sealing member engages the second portion of the barrel to give rise to a second contact pressure that is lower than the first contact pressure.Type: GrantFiled: March 14, 2013Date of Patent: June 6, 2017Assignee: AbbVie Inc.Inventors: Sean E. Mackey, Ji Zhou, Martin J. Gibler, Dennis Y. Lee
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Publication number: 20130085181Abstract: The present invention provides a modified release formulation comprising an active agent in a hydrophilic polymer matrix wherein the active agent is a salt of fenofibric acid wherein the release rate of the formulation in an in vitro dissolution is substantially independent of the ionic strength of the dissolution media.Type: ApplicationFiled: May 31, 2012Publication date: April 4, 2013Inventors: Yi Gao, Tzuchi R. Ju, Dennis Y. Lee, Nicole Nguyen, Huailiang Wu
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Publication number: 20120276008Abstract: In one embodiment, the invention relates to a composition suitable for preparing a hydrogel useful as replacement material for all or part of a disc nucleus. The composition comprises: a curable, cross-linkable, non-immunogenic, non-toxic protein comprising a minimum of about 10% and a maximum of about 25% of the hydrogel by weight; a metal contrast agent comprising a minimum of about 2% and a maximum of about 70% of the hydrogel by weight; and a crosslinker comprising a minimum of about 0.1% and a maximum of about 10% of the hydrogel by weight; wherein the composition has a discernable radiopacity level.Type: ApplicationFiled: April 26, 2011Publication date: November 1, 2012Applicant: SPINE WAVE, INC.Inventors: Jared W. Walkenhorst, Keith A. Collins, Dennis Y. Lee, Thomas G. Wilson, Thomas J. Douville, Ulrich Berlemann
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Publication number: 20110237675Abstract: The present invention provides a modified release formulation comprising an active agent in a hydrophilic polymer matrix wherein the active agent is a salt of fenofibric acid wherein the release rate of the formulation in an in vitro dissolution is substantially independent of the ionic strength of the dissolution media.Type: ApplicationFiled: June 2, 2011Publication date: September 29, 2011Applicant: Abbott LaboratoriesInventors: Yi Gao, Tzuchi R. Ju, Dennis Y. Lee, Nicole Nguyen, Huailiang Wu
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Patent number: 7994078Abstract: The present invention provides a nonwoven web prepared from an aliphatic polyester polymer which has sufficient tear strength and is biodegradable. Biodegradable nonwoven webs of the present are prepared from a polymer blend having from about 65% by weight to about 99% by weight of a biodegradable aliphatic polyester polymer and from about 1% by weight to about 35% by weight of a second polymer selected from the group consisting of a polymer having a lower melting point than the biodegradable aliphatic polyester polymer, a polymer having a lower molecular weight than the biodegradable aliphatic polyester polymer and mixtures thereof. Surprisingly, the nonwoven webs of the present invention have a tear strength greater than the tear strength of a nonwoven web prepared from the biodegradable aliphatic polyester polymer alone.Type: GrantFiled: December 10, 2003Date of Patent: August 9, 2011Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Mark G. Reichmann, Maya Aroch, Joy Francine Jordan, Peter Michailovich Kobylivker, Rowland Jaynes McClellan, Jr., Ann Louise McCormack, Palani Raj Ramaswami Wallajapet, Vasily A. Topolkaraev, Dennis Y. Lee, Steven R. Stopper
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Patent number: 7704341Abstract: In a method and apparatus for forming a bonded web comprised at least in part of a polyester, a first material web and a second material web are arranged in opposed relationship with each other at least along those portions of the first and second material webs to be bonded together. At least one of the first and second material webs is comprised at least in part of the polyester. The opposed webs are transported in a machine direction to the nip of a bonding apparatus comprised of a first bonding member and a second bonding member defining the nip therebetween for passage of the opposed first and second material webs therebetween in the machine direction. A shear force is applied to the webs generally in the machine direction at the nip and the webs are mechanically bonded together at the nip while the shear force is applied to webs.Type: GrantFiled: December 15, 2005Date of Patent: April 27, 2010Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Vasily Aramovich Topolkaraev, Barton Andrew Laughlin, John Ford Condron, Patrick Martin Downey, Thomas David Ehlert, Dennis Y. Lee, Patrick Sean McNichols, Nagabhusan Senapati, Palani Raj Ramaswami Wallajapet
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Patent number: 7607191Abstract: An adjustable-size mop head assembly that may be used with a handle and a disposable cleaning substrate is disclosed. The mop head assembly includes a central frame section with a central portion and a lower substrate support surface configured to hold a disposable cleaning substrate. The mop head assembly also includes at least one adjunct frame section configured to be operably coupled to the central frame section and configured to move between a stored configuration, where the adjunct frame section is stored by the central frame section, and an extended configuration where the adjunct frame section extends from the central frame section to add width to the central frame section and the lower substrate support surfaces. A continuous web of disposable cleaning substrate that may be used with the adjustable-size mop head assembly is also disclosed.Type: GrantFiled: July 18, 2006Date of Patent: October 27, 2009Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Cameron Ray Morris, Stephanie Ann Rossignol, George Nukuto, Denis R. Grimard, Carl G. Rippl, MeeWha Lee, Paul Woon, Russell J. Kroll, Mark Londborg, Robert Henshaw, Kiran K. Reddy, Thomas Glenn Merrill, Jose Ricardo Rubio-Flores, Jr., Dennis Y. Lee, Nathan P. Hendon
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Publication number: 20080152714Abstract: The present invention provides a modified release formulation comprising an active agent in a hydrophilic polymer matrix wherein the active agent is a salt of fenofibric acid wherein the release rate of the formulation in an in vitro dissolution is substantially independent of the ionic strength of the dissolution media.Type: ApplicationFiled: October 12, 2007Publication date: June 26, 2008Inventors: Yi Gao, Tzuchi R. Ju, Dennis Y. Lee, Nicole Nguyen, Huailiang Wu
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Publication number: 20080016639Abstract: An adjustable-size mop head assembly that may be used with a handle and a disposable cleaning substrate is disclosed. The mop head assembly includes a central frame section with a central portion and a lower substrate support surface configured to hold a disposable cleaning substrate. The mop head assembly also includes at least one adjunct frame section configured to be operably coupled to the central frame section and configured to move between a stored configuration, where the adjunct frame section is stored by the central frame section, and an extended configuration where the adjunct frame section extends from the central frame section to add width to the central frame section and the lower substrate support surfaces. A continuous web of disposable cleaning substrate that may be used with the adjustable-size mop head assembly is also disclosed.Type: ApplicationFiled: July 18, 2006Publication date: January 24, 2008Inventors: Cameron Ray Morris, Stephanie Ann Rossignol, George Nukuto, Denis R. Grimard, Carl G. Rippl, MeeWha Lee, Paul Woon, Russell J. Kroll, Mark Londborg, Robert Henshaw, Kiran K. Reddy, Thomas Glenn Merrill, Jose Ricardo Rubio-Flores, Dennis Y. Lee, Nathan P. Hendon
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Publication number: 20070137762Abstract: In a method and apparatus for forming a bonded web comprised at least in part of a polyester, a first material web and a second material web are arranged in opposed relationship with each other at least along those portions of the first and second material webs to be bonded together. At least one of the first and second material webs is comprised at least in part of the polyester. The opposed webs are transported in a machine direction to the nip of a bonding apparatus comprised of a first bonding member and a second bonding member defining the nip therebetween for passage of the opposed first and second material webs therebetween in the machine direction. A shear force is applied to the webs generally in the machine direction at the nip and the webs are mechanically bonded together at the nip while the shear force is applied to webs.Type: ApplicationFiled: December 15, 2005Publication date: June 21, 2007Applicant: Kimberly-Clark Worldwide, Inc.Inventors: Vasily Aramovich Topolkaraev, Barton Andrew Laughlin, John Ford Condron, Patrick Martin Downey, Thomas David Ehlert, Dennis Y. Lee, Patrick Sean McNichols, Nagabhusan Senapati, Palani Raj Ramaswami Wallajapet
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Publication number: 20040166758Abstract: The present invention provides a nonwoven web prepared from an aliphatic polyester polymer which has sufficient tear strength and is biodegradable. Biodegradable nonwoven webs of the present are prepared from a polymer blend having from about 65% by weight to about 99% by weight of a biodegradable aliphatic polyester polymer and from about 1% by weight to about 35% by weight of a second polymer selected from the group consisting of a polymer having a lower melting point than the biodegradable aliphatic polyester polymer, a polymer having a lower molecular weight than the biodegradable aliphatic polyester polymer and mixtures thereof. Surprisingly, the nonwoven webs of the present invention have a tear strength greater than the tear strength of a nonwoven web prepared from the biodegradable aliphatic polyester polymer alone.Type: ApplicationFiled: December 10, 2003Publication date: August 26, 2004Inventors: Mark G. Reichmann, Maya Aroch, Joy Francine Jordan, Peter Michailovich Kobylivker, Rowland Jaynes McClellan, Ann Louise McCormack, Palani Raj Ramaswami Wallajapet, Vasily A. Topolkaraev, Dennis Y. Lee, Steven R. Stopper
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Publication number: 20020006933Abstract: Methods for administering apomorphine to a patient for the treatment of sexual dysfunctions while reducing undesirable side effects are disclosed. In the methods, the concentration of apomorphine is attained within the patients' plasma of up to 10 nanograms per milliliter. Advantageously, this concentration may be achieved with less than 15% of patients so treated experiencing emesis. Methods of administration are intranasally, by inhalation to the lungs or by oral ingestion.Type: ApplicationFiled: March 14, 2001Publication date: January 17, 2002Applicant: TAP Holdings, Inc.Inventors: Pramod K. Gupta, John Daniel Bollinger, Yisheng Chen, Jack Yuqun Zheng, Thomas L. Reiland, Dennis Y. Lee