Abstract: A restraint device which can be quickly and easily installed in a vehicle to restrain wheelchairs from moving in any direction. A base of the device bolts to the floor of a vehicle used to transport the physically handicapped. A pair of vertically inclined rods connected to the base are positioned on either side of a space for a wheelchair. A clamping member slidably mounted on each of the inclined rods rests against the top of a large wheel of the wheelchair to clamp the wheel between the clamping member and a horizontal rod connected to the base of the restraint device. The clamping members can be easily locked in position and unlocked by a patient in the wheelchair using very little pressure and requiring very little dexterity. The device prevents forward, backward, upward and sideways movement of a wheelchair which has thus been locked in position.