Patents by Inventor Denong Wang
Denong Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230104050Abstract: Example methods comprise administering an immunogenic vaccine composition to a subject, the immunogenic vaccine composition comprising a glycoconjugate. The method can further comprise, in response to the administration of the immunogenic vaccine composition, inducing production of anti-oligomannose antibodies in the subject and thereby eliciting an immune response to a viral pathogen in the subject.Type: ApplicationFiled: February 12, 2021Publication date: April 6, 2023Applicant: SRI InternationalInventors: Denong Wang, Lisa Wu
-
Publication number: 20190383820Abstract: Embodiments in accordance with the present disclosure include apparatuses, devices, and methods. An example method is directed to detecting cancer stem cells (CSCs) in a biological sample of a subject. The method includes causing a physical interaction between the biological sample and an antibody by exposing the biological sample to the antibody and determining a presence of CSCs in the biological sample by detecting binding between the antibody and a glycan biomarker. The glycan biomarker includes at least one chain selected from the group consisting of polylactosamine chains, oligosaccharide chains, and combinations thereof, the at least one chain having branches selected from the group consisting of II? (Gal?1,4GlcNAc?1,6), II?/I? (Gal ?1,3GlcNAc ?1,6), II?/I? (Gal ?1 4/3GlcNAc ?1,6)-moieties, and combinations thereof.Type: ApplicationFiled: January 18, 2018Publication date: December 19, 2019Inventor: Denong Wang
-
Patent number: 10345308Abstract: Anti-carbohydrate antibodies are detected by (a) contacting an array of oligomannose-serum albumin conjugates immobilized on a substrate with an antibody-containing serum sample under conditions wherein TM10 antibodies bind the oligomannose of the conjugates at at least micromolar affinity; and (b) detecting resultant binding of specific antibodies of the sample to the oligomannose of the conjugates, as indicative of the anti-carbohydrate antibodies.Type: GrantFiled: October 23, 2014Date of Patent: July 9, 2019Assignee: SRI INTERNATIONALInventor: Denong Wang
-
Patent number: 9454077Abstract: Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.Type: GrantFiled: January 5, 2015Date of Patent: September 27, 2016Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Gregory T. Carroll, Jeffrey T. Koberstein, Denong Wang, Nicholas J. Turro
-
Publication number: 20160231649Abstract: Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.Type: ApplicationFiled: January 5, 2015Publication date: August 11, 2016Inventors: Gregory T. CARROLL, Jeffrey T. KOBERSTEIN, Denong WANG, Nicholas J. TURRO
-
Patent number: 9164108Abstract: This invention provides novel liposome-based articles of manufacture and microarrays and methods of making and using them (1) to detect the presence of one or more agents in a sample, (2) to determine the amount of one or more agents in a sample, and (3) to determine whether a subject is afflicted with a disorder. This invention also provides kits which comprise the instant microarrays.Type: GrantFiled: March 22, 2006Date of Patent: October 20, 2015Assignee: SRI INTERNATIONALInventors: Denong Wang, Leonore A. Herzenberg, Lawrenes Steinman
-
Publication number: 20150265691Abstract: This invention provides a vaccine comprising (i) an anthrose-containing saccharide in an amount effective to enhance immunity against Bacillus anthracis in a subject and (ii) a pharmaceutically acceptable carrier. This invention provides a vaccine comprising (i) a conjugate of an anthrose-containing saccharide in an amount effective to enhance immunity against Bacillus anthracis in a subject, wherein the anthrose-containing saccharide is conjugated to a biomolecule via a linker, and (ii) a pharmaceutically acceptable carrier.Type: ApplicationFiled: September 14, 2007Publication date: September 24, 2015Inventors: Denong Wang, Pavol Kovac, Lawrence Steinman, Gregory Carroll, Nicholas Turro, Jeffrey Koberstein, Rina Saksena, Roberto Adamo
-
Publication number: 20150051106Abstract: Anti-carbohydrate antibodies are detected by (a) contacting an array of oligomannose-serum albumin conjugates immobilized on a substrate with an antibody-containing serum sample under conditions wherein TM10 antibodies bind the oligomannose of the conjugates at at least micromolar affinity; and (b) detecting resultant binding of specific antibodies of the sample to the oligomannose of the conjugates, as indicative of the anti-carbohydrate antibodies.Type: ApplicationFiled: October 23, 2014Publication date: February 19, 2015Applicant: SRI INTERNATIONALInventor: Denong Wang
-
Patent number: 8957225Abstract: Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.Type: GrantFiled: March 9, 2012Date of Patent: February 17, 2015Assignee: The Trustees of Columbia University in the City of New YorkInventors: Gregory T. Carroll, Jeffrey T. Koberstein, Denong Wang, Nicholas J. Turro
-
Patent number: 8658573Abstract: The invention relates to novel photo-generated carbohydrate arrays and methods of their use to detect the presence of one or more agents in a sample. The invention also relates to a high-throughput strategy to facilitate the identification and immunological characterization of pathogen-specific carbohydrates, including those of Bacillus anthracis. The invention can be used to determine the presence of a pathogen and whether a subject has been exposed to a pathogen, such as by screening for pathogen-specific antibodies.Type: GrantFiled: September 11, 2007Date of Patent: February 25, 2014Assignee: The Trustees of Columbia University in the City of New YorkInventors: Denong Wang, Gregory T. Carroll, Nicholas J. Turro, Jeffrey T. Koberstein
-
Publication number: 20120178650Abstract: Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.Type: ApplicationFiled: March 9, 2012Publication date: July 12, 2012Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Gregory T. Carroll, Jeffrey T. Koberstein, Denong Wang, Nicholas J. Turro
-
Patent number: 8158832Abstract: Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.Type: GrantFiled: November 9, 2006Date of Patent: April 17, 2012Assignee: The Trustees of Columbia University in the City of New YorkInventors: Gregory T. Carroll, Denong Wang, Nicholas J. Turro, Jeffrey T. Koberstein
-
Patent number: 8133492Abstract: This invention provides novel nitrocellulose-based or Hydrogel-based microarrays and methods of making and using them (1) to detect the presence of one or more agents in a sample, (2) to determine the amount of one or more agents in a sample, (3) to determine whether a subject is afflicted with a disorder, and (4) to determine whether an agent known to specifically bind to a first compound also specifically binds to a second compound. This invention also provides kits which comprise the instant microarrays. This invention further provides antibodies capable of specifically binding to a glycomer present both on the surface of a mammalian macrophage or intestinal epithelial cell, and on a bacterial cell. Finally, this invention provides diagnostic methods using the instant antibodies.Type: GrantFiled: June 21, 2006Date of Patent: March 13, 2012Assignee: The Trustees of Columbia University in the City of New YorkInventor: Denong Wang
-
Publication number: 20110177090Abstract: The present invention provides compositions and methods for the specific and sensitive detection and characterization of anti-carbohydrate antibodies against immunogenic sugar moieties on microbes and abnormal cells and anti-HIV-1 protein antibodies for the development of diagnostic, prophylactic and therapeutic strategies against diseases inflicted by cancer cells or microbial pathogens.Type: ApplicationFiled: January 19, 2011Publication date: July 21, 2011Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Denong Wang, Leonore A. Herzenberg
-
Patent number: 7981625Abstract: Disclosed are methods for probing the immunogenic sugar moieties of prostate cancer cells. The methods detect a number of glyco-epitopes that are highly and differentially expressed among prostate cancers of various Gleason grades. The glyco-epitopes exist on the surfaces of prostate cells. The methods also comprise the detection of autoantibodies in prostate cancer subjects. The antibodies bound to a glyco-motif of N-glycans that is normally “cryptic.” This target is highly expressed in prostate cancers. Lectins and antibodies that detect these glyco-epitopes that expressed in prostate cancer tissues include Euonymus europaeus lectin (EEL); Psophocarpus Tetragonolobus Lectin-I (PTL-I); Griffonia Simplicifolia Lectin-I-A4 (GSL-I-A4); Griffonia Simplicifolia Lectin-I-B4 (GSL-I-B4); Sambucus nigra I agglutinin (SNA-I; Phaseolus vulgaris-L (PHA-L; Galanthus nivalis agglutinin (GNA); Narcissus pseudonarcissus agglutinin (NPA); Artocarpus integrifolia agglutinin (Jacalin); and mAb TM10 (IgM).Type: GrantFiled: April 10, 2009Date of Patent: July 19, 2011Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Denong Wang, Leonore A. Herzenberg, Donna M. Peehl, Leonard A. Herzenberg
-
Publication number: 20100331198Abstract: The invention relates to novel photo-generated carbohydrate arrays and methods of their use to detect the presence of one or more agents in a sample. The invention also relates to a high-throughput strategy to facilitate the identification and immunological characterization of pathogen-specific carbohydrates, including those of Bacillus anthracis. The invention can be used to determine the presence of a pathogen and whether a subject has been exposed to a pathogen, such as by screening for pathogen-specific antibodies.Type: ApplicationFiled: September 11, 2007Publication date: December 30, 2010Inventors: Denong Wang, Gregory T. Carroll, Nicholas J. Turro, Jeffrey T. Koberstein
-
Publication number: 20100178292Abstract: The present invention relates to a novel glycan marker of cancer and monoclonal antibodies against it. Furthermore, novel glycan markers and their use in the detection and monitoring of cancerous cells and cancer-associated or specific antibody signatures are described.Type: ApplicationFiled: January 12, 2010Publication date: July 15, 2010Applicants: The Board of Trustees of the Leland Stanford Junior University, Imperial College of LondonInventors: Denong Wang, Thomas Newsom-Davis, Lawrence Steinman, Gavin Screaton
-
Publication number: 20100099580Abstract: Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.Type: ApplicationFiled: November 9, 2006Publication date: April 22, 2010Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Gregory T. Carroll, Jeffrey T. Koberstein, Denong Wang, Nicholas J. Turro
-
Publication number: 20090258792Abstract: Disclosed are methods for probing the immunogenic sugar moieties of prostate cancer cells. The methods detect a number of glyco-epitopes that are highly and differentially expressed among prostate cancers of various Gleason grades. The glyco-epitopes exist on the surfaces of prostate cells. The methods also comprise the detection of autoantibodies in prostate cancer subjects. The antibodies bound to a glyco-motif of N-glycans that is normally “cryptic.” This target is highly expressed in prostate cancers. Lectins and antibodies that detect these glyco-epitopes that expressed in prostate cancer tissues include Euonymus europaeus lectin (EEL); Psophocarpus Tetragonolobus Lectin-I (PTL-I); Griffonia Simplicifolia Lectin-I-A4 (GSL-I-A4); Griffonia Simplicifolia Lectin-I-B4 (GSL-I-B4); Sambucus nigra I agglutinin (SNA-I; Phaseolus vulgaris-L (PHA-L; Galanthus nivalis agglutinin (GNA); Narcissus pseudonarcissus agglutinin (NPA); Artocarpus integrifolia agglutinin (Jacalin); and mAb TM10 (IgM).Type: ApplicationFiled: April 10, 2009Publication date: October 15, 2009Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Denong Wang, Leonore A. Herzenberg, Donna M. Peehl, Leonard A. Herzenberg
-
Publication number: 20070059765Abstract: This invention provides novel liposome-based articles of manufacture and microarrays and methods of making and using them (1) to detect the presence of one or more agents in a sample, (2) to determine the amount of one or more agents in a sample, and (3) to determine whether a subject is afflicted with a disorder. This invention also provides kits which comprise the instant microarrays.Type: ApplicationFiled: March 22, 2006Publication date: March 15, 2007Inventors: Denong Wang, Leonore Herzenberg, Lawrenes Steinman