Patents by Inventor Denuja KARUNAKARAN

Denuja KARUNAKARAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR DETECTION, RISK ASSESSMENT AND TREATMENT OF DIABETES, OBESITY, AND INFLAMMATION
    Publication number: 20200147118
    Abstract: Provided are compounds and compositions associated with obesity, diabetes and inflammation and methods of treating the same.
    Type: Application
    Filed: November 9, 2018
    Publication date: May 14, 2020
    Inventors: Katey Rayner, Denuja Karunakaran, Ruth McPherson
  • IDENTIFICATION AND TREATMENT OF VULNERABLE PLAQUES
    Publication number: 20160324992
    Abstract: A method of detecting an atherosclerotic plaque vulnerable to rupture in a subject comprises providing to the subject a labelled necrostatin or a derivative thereof, and visualizing the label, wherein a localization of the label in a plaque indicates the plaque is vulnerable to rupture. A method of detecting and treating an atherosclerotic plaque vulnerable to rupture comprises providing to the subject a labelled necrostatin or a derivative thereof, visualizing the label, wherein a localization of the label in a plaque indicates the plaque is vulnerable to rupture; and providing a necroptosis inhibitor or derivative thereof to the subject when the visualizing indicates that the plaque is vulnerable to rupture. The necroptosis inhibitor may comprise a necrostatin, such as Nec-1. The label may be a radiolabel such as 123I. By visualizing plaques vulnerable to rupture, atherosclerotic plaques may be identified and treated in advance of rupture.
    Type: Application
    Filed: May 5, 2016
    Publication date: November 10, 2016
    Inventors: Katey J. RAYNER, Terrence David RUDDY, Denuja KARUNAKARAN, Lihui WEI