Patents by Inventor Depu Chen
Depu Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9512001Abstract: This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be surface-modified. The nanoparticles can be used in many biological assays.Type: GrantFiled: December 16, 2010Date of Patent: December 6, 2016Assignees: CAPITALBIO CORPORATION, TSINGHUA UNIVERSITYInventors: Huachang Lu, Guangshun Yi, Depu Chen, Lianghong Guo, Jing Cheng
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Publication number: 20120228386Abstract: This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on said substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof. In certain embodiments, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.Type: ApplicationFiled: May 21, 2012Publication date: September 13, 2012Applicant: Aviva Biosciences CorporationInventors: Lei WU, Xiaobo Wang, Guoliang Tao, Junquan Xu, Jing Cheng, Mingxian Huang, Baoquan Sun, Wei Shao, Litian Liu, Depu Chen, David M. Rothwarf, Weiping Yang
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Publication number: 20110177339Abstract: This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be surface-modified. The nanoparticles can be used in many biological assays.Type: ApplicationFiled: December 16, 2010Publication date: July 21, 2011Inventors: Huachang Lu, Guangshun Yi, Depu Chen, Lianghong Guo, Jing Cheng
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Patent number: 7875466Abstract: This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be surface-modified. The nanoparticles can be used in many biological assays.Type: GrantFiled: August 13, 2003Date of Patent: January 25, 2011Assignees: CapitalBio Corporation, Tsinghua UniversityInventors: Huachang Lu, Guangshun Yi, Depu Chen, Lianghong Guo, Jing Cheng
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Publication number: 20100260984Abstract: This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on said substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof. In certain embodiments, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.Type: ApplicationFiled: April 14, 2010Publication date: October 14, 2010Applicants: AVIVA BIOSCIENCES CORPORATION, TSINGHUA UNIVERSITY, CAPITALBIO CORPORATIONInventors: Lei WU, Xiaobo Wang, Guoliang Tao, Junquan Xu, Jing Cheng, Mingxian Huang, Baoquan Sun, Wei Shao, Litian Liu, Depu Chen, David M. Rothwarf, Weiping Yang
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Microdevice containing photorecognizable coding patterns and methods of using and producing the same
Patent number: 7811768Abstract: This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on the substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof.Type: GrantFiled: August 7, 2001Date of Patent: October 12, 2010Assignees: Aviva Biosciences Corporation, Tsinghua University, CAPTIALBIO CorporationInventors: Lei Wu, Xiaobo Wang, Guoliang Tao, Junquan Xu, Jing Cheng, Mingxiang Huang, Baoquan Sun, Wei Shao, Litian Liu, Depu Chen, David M. Rothwarf, Weiping Yang -
Microdevice containing photorecognizable coding patterns and methods of using and producing the same
Patent number: 7776543Abstract: This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on the substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof.Type: GrantFiled: August 7, 2001Date of Patent: August 17, 2010Assignees: Aviva Biosciences Corporation, Tsinghua University, CAPTIALBIO CorporationInventors: Lei Wu, Xiaobo Wang, Guoliang Tao, Junquan Xu, Jing Cheng, Mingxiang Huang, Baoquan Sun, Wei Shao, Litian Liu, Depu Chen, David M. Rothwarf, Weiping Yang -
Patent number: 7776580Abstract: This invention relates generally to the field of cell seperation. In particular, the invention provides processes for isolating a target cell, cellular organelle or virus from a sample, using inter alia, nonspecific binding between a target cell, cellular organelle or virus with a magnetic microbead modified to comprise hydroxyl, carboxyl or epoxy groups.Type: GrantFiled: December 31, 2002Date of Patent: August 17, 2010Assignees: CapitalBio Corporation, Tsinghua UniversityInventors: Xu Zhang, Xin Xie, Depu Chen, Weiyang Fei, Jing Cheng
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Patent number: 7718419Abstract: This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.Type: GrantFiled: August 20, 2007Date of Patent: May 18, 2010Assignee: Aviva Biosciences CorporationInventors: Lei Wu, Xiaobo Wang, Guoliang Tao, Junquan Xu, Jing Cheng, Mingxian Huang, Baoquan Sun, Wei Shao, Litian Liu, Depu Chen, David M. Rothwarf, Weiping Yang
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Patent number: 7422703Abstract: Nanometer-scaled up-converting fluoride phosphor particles and processes of making them are disclosed. In the process, an aqueous solution consisting of soluble salts of rare-earth metal ions at a molar ratio of (yttrium, lanthanum or gadolinium): ytterbium:(erbium, holmium, terbium or thulium)=(70-90):(0-29):(0.001-15) is mixed a rare-earth metal chelator and a soluble fluoride salt to form precipitates, which are then annealed at an elevated temperature to produce nanometer-scaled up-converting fluoride phosphor particles. The particle size is between 35 nm and 200 nm, and can be controlled by the amount of the metal chelator added to the solution. The nanometer-sized particle is applicable to many biological assays.Type: GrantFiled: April 15, 2003Date of Patent: September 9, 2008Assignee: Capital Biochip Company LtdInventors: Guangshun Yi, Baoquan Sun, Depu Chen, Yuxiang Zhou, Jing Cheng, Wenjun Yang, Yue Ge, Lianghong Guo
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Publication number: 20080200349Abstract: This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.Type: ApplicationFiled: August 20, 2007Publication date: August 21, 2008Applicants: AVIVA BIOSCIENCES CORPORATION, TSINGHUA UNIVERSITY, CAPITAL BIOCHIP CORPORATIONInventors: Lei Wu, Xiaobo Wang, Guoliang Tao, Junquan Xu, Jing Cheng, Mingxiang Huang, Baoquan Sun, Wei Shao, Litian Liu, Depu Chen, David M. Rothwarf, Weiping Yang
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Publication number: 20070059705Abstract: This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be surface-modified. The nanoparticles can be used in many biological assays.Type: ApplicationFiled: August 13, 2003Publication date: March 15, 2007Inventors: Huachang Lu, Guangshun Yi, Depu Chen, Lianghong Guo, Jing Cheng
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Publication number: 20060166190Abstract: This invention relates generally to the field of nucleic acid amplification. In particular, the invention provides processes and kits for amplifying a nucleic acid of a target cell or virus using, using inter alia, binding between a target cell, cellular organelle or virus with a magnetic microbead.Type: ApplicationFiled: December 31, 2002Publication date: July 27, 2006Inventors: Xin Xie, Xu Zhang, Depu Chen, Weiyang Fei, Jing Chen
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Publication number: 20060141450Abstract: This invention relates generally to the field of. In particular, the invention provides processes and kits for isolating a target cell, cellular organelle or virus from a sample, using inter alia, non- or low-specific binding between a target cell, cellular organelle or virus with a magnetic microbead.Type: ApplicationFiled: December 31, 2002Publication date: June 29, 2006Inventors: Xu Zhang, Xin Xie, Depu Chen, Weiyang Fei, Jing Cheng
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Publication number: 20060003466Abstract: Nanometer-scaled up-converting fluoride phosphor particles and processes of making them are disclosed. In the process, an aqueous solution consisting of soluble salts of rare-earth metal ions at a molar ratio of (yttrium, lanthanum or gadolinium): ytterbium:(erbium, holmium, terbium or thulium)=(70-90):(0-29):(0.001-15) is mixed a rare-earth metal chelator and a soluble fluoride salt to form precipitates, which are then annealed at an elevated temperature to produce nanometer-scaled up-converting fluoride phosphor particles. The particle size is between 35 nm and 200 nm, and can be controlled by the amount of the metal chelator added to the solution. The nanometer-sized particle is applicable to many biological assays.Type: ApplicationFiled: April 15, 2003Publication date: January 5, 2006Inventors: Guangshun Yi, Baoquan Sun, Depu Chen, Yuxiang Zhou, Jing Cheng, Wenjun Yang, Yue Ge, Lianghong Guo
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Publication number: 20050009002Abstract: This invention relates generally to the field of production of coated magnetizable microparticles and uses thereof. In particular, the invention provides a process for producing coated magnetizable microparticles with active functional groups, which process uses, inter alia, conducting polymerization of said coating monomers on the surface of magnetic particle to form coated magnetizable microparticles with active functional groups in the presence of a coupling agent, coating monomers, a functionalization reagent, a cross-linking agent and an initiator in an organic solvent containing a surfactant. The coated magnetizable microparticles produced according to the present processes and uses of the coated magnetizable microparticles, e.g., in isolating and/or manipulating various moieties are also provided.Type: ApplicationFiled: March 20, 2002Publication date: January 13, 2005Inventors: Depu Chen, Xin Xie, Xu Zhang, Baoquan Sun
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Patent number: 6806050Abstract: This invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents. An electromagnetic biochip comprises an individually addressable micro-electromagnetic unit chip with ligand molecules immobilized on its surface. By controlling the electromagnetic field at each unit of the array and combining this control with magnetic modification of biomolecules, these chips can be used for directed manipulation, synthesis and release of biomolecules in order to increase sensitivity of biochemical or chemical analysis and reduce assay time. Other advantages with these chips include minimized damages to biological molecules and increased reproducibility of assay results.Type: GrantFiled: September 18, 2001Date of Patent: October 19, 2004Assignee: AVIVA BiosciencesInventors: Yuxiang Zhou, Litian Liu, Ken Chen, Depu Chen, Jia Wang, Zewen Liu, Zhimin Tan, Junquan Xu, Xiaoshan Zhu, Xuezhong He, Wenzhang Xie, Zhiming Li, Xiumel Liu
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Publication number: 20020137059Abstract: This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on said substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof.Type: ApplicationFiled: August 7, 2001Publication date: September 26, 2002Inventors: Lei Wu, Xiaobo Wang, Gouliang Tao, Junquan Xu, Jing Cheng, Mingxiang Huang, Baoquan Sun, Wei Shao, Litian Liu, Depu Chen, David M. Rothwarf, Weiping Yang
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Patent number: 6355491Abstract: This invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents. An electromagnetic biochip comprises an individually addressable micro-electromagnetic unit chip with ligand molecules immobilized on its surface. By controlling the electromagnetic field at each unit of the array and combining this control with magnetic modification of biomolecules, these chips can be used for directed manipulation, synthesis and release of biomolecules in order to increase sensitivity of biochemical or chemical analysis and reduce assay time. Other advantages with these chips include minimized damages to biological molecules and increased reproducibility of assay results.Type: GrantFiled: September 17, 1999Date of Patent: March 12, 2002Assignee: Aviva BiosciencesInventors: Yuxiang Zhou, Litian Liu, Ken Chen, Depu Chen, Jia Wang, Zewen Liu, Zhimin Tan, Junquan Xu, Xiaoshan Zhu, Xuezhong He, Wenzhang Xie, Zhiming Li, Xiumei Liu
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Publication number: 20020022276Abstract: This invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents. An electromagnetic biochip comprises an individually addressable micro-electromagnetic unit chip with ligand molecules immobilized on its surface. By controlling the electromagnetic field at each unit of the array and combining this control with magnetic modification of biomolecules, these chips can be used for directed manipulation, synthesis and release of biomolecules in order to increase sensitivity of biochemical or chemical analysis and reduce assay time. Other advantages with these chips include minimized damages to biological molecules and increased reproducibility of assay results.Type: ApplicationFiled: September 18, 2001Publication date: February 21, 2002Inventors: Yuxiang Zhou, Litian Liu, Ken Chen, Depu Chen, Jia Wang, Zewen Liu, Zhimin Tan, Junquan Xu, Xiaoshan Zhu, Xuezhong He, Wenzhang Xie, Zhiming Li, Xiumei Liu