Abstract: A siphon guard includes a housing having an inlet and an outlet. A primary flow path is disposed within the housing and is in fluid communication with the inlet and the outlet. A secondary flow path is disposed within the housing and is in fluid communication with the inlet and the outlet. The secondary flow path has a higher resistance to fluid flow than the primary path. A valve is disposed within the primary flow path. The valve has a valve seat and a first ball and a second ball. The first ball is movable by gravity between a valve closed position, where the first ball is in contact with the valve seat, and a valve open position, where the first ball is spaced from the valve seat. The first ball is disposed between the second ball and the valve seat. The second ball is movable by gravity between a valve closed position and a valve opened position.

Abstract: Bone anchor assemblies and methods are provided having a multi-component bone anchor that is configured to allow the shank of the bone anchor to be bottom loaded into a receiver member. In one embodiment, a bone anchor assembly is provided having a shank with a distal threaded portion and a proximal head portion, a receiver member having an aperture formed in a distal end thereof through which the head portion of the shank can be received, the receiver member defining a polyaxial seat, a non-expandable outer ring configured to be polyaxially disposed within the polyaxial seat of the receiver member and defining a central opening through which the head portion of the shank can be received, and an expandable inner ring having an inner surface configured to mate with the head portion of the shank and an outer surface configured to mate with an inner surface of the outer ring to thereby lock the outer ring in a fixed position relative to the shank.

Abstract: Systems and methods for manipulating a spinal construct are provided herein. In general, the system includes first and second sleeves extending from vertebrae and a fulcrum that can be releasably coupled to the sleeves. In certain aspects, the fulcrum can receive a portion of the sleeves therein and can allow the sleeves to pivot about the fulcrum in response to an applied force. The fulcrum can releasably couple to the sleeves in a variety of ways, and a position of the fulcrum relative to the sleeves can vary depending on whether there is an applied distracting, compressing, and/or derotating force. In some embodiments, user can manipulate the first and second sleeves relative to the fulcrum, using one hand, to distract, compress, and/or derotate the vertebrae.

Abstract: A kit includes an orthopaedic implant stem, and a reamer assembly for reaming a proximal portion of a cavity, said reamer assembly cooperating with a proximal portion of the orthopaedic implant stem, said reamer assembly comprising, a sleeve defining an inner periphery, said sleeve configured to fit over the proximal portion of the orthopaedic implant stem, said sleeve defining an outer periphery, and a reamer including a body defining a cavity formed therein for receiving at least a portion of the outer periphery of said sleeve, a plurality of cutting edges extending outwardly from said body, said cutting edges adapted for cooperation with bone, and a stem extending from an end of the body, wherein the sleeve comprises a locking feature and the stem comprises a connection feature to removably secure the sleeve to the proximal portion of the orthopaedic implant stem when assembled together.

Abstract: A method for providing joint arthroplasty includes resecting an end portion of a long bone, preparing a central longitudinal opening in a medullary canal of the long bone, providing a prosthetic stem component, installing the prosthetic stem component into the opening in a medullary canal, providing a reamer including an opening for receiving the prosthetic stem component, positioning the reamer onto the prosthetic stem component with the opening of the reamer positioned at least partially over the prosthetic stem component, reaming a portion of the long bone with the reamer, removing the reamer, and installing a prosthetic body component onto the prosthetic stem component.

Abstract: An intervertebral implant for fusing vertebrae is disclosed. The implant may have a body with curved, posterior and anterior faces separated by two narrow implant ends, superior and inferior faces having a plurality of undulating surfaces for contacting vertebral endplates, and at least one depression in the anterior or posterior face for engagement by an insertion tool. The implant may also have one or more vertical through-channels extending through the implant from the superior face to the inferior face, a chamfer on the superior and inferior surfaces at one of the narrow implant ends, and/or a beveled edge along a perimeter of the superior and inferior faces. The implant configuration facilitates transforaminal insertion of the implant into a symmetric position about the midline of the spine so that a single implant provides balanced support to the spinal column. The implant may be formed of a plurality of interconnecting bodies assembled to form a single unit.

Abstract: An occlusive device suitable for endovascular treatment of an aneurysm in a region of a parent vessel in a patient, including a structure having a pre-established pore features and having dimensions suitable for insertion into vasculature of the patient to reach the region of the aneurysm in the parent vessel. The device further includes a frangible material associated with the pore features which initially provides a substantial barrier to flow through the frangible material and is capable of at least one of localized rupturing and localized eroding, in the presence of a pressure differential arising at an ostium of a perforator vessel communicating with the parent vessel, within an acute time period to minimize ischemia downstream of the perforator vessel.

Abstract: A method of fabricating a frangible material for an occlusive device suitable for endovascular treatment of an aneurysm in a region of a parent vessel in a patient, including selecting first and second spray devices having first and second nozzle openings and first and second adjustable flow controls, respectively. The first and second spray devices are arranged to deliver droplets of a first liquid including at least one biocompatible polymer through the first spray device and to deliver droplets of a second liquid including a non-solvent for the polymer through the second spray device in an overlapping spray pattern on a substrate at a pre-selected distance and a pre-selected relative translation speed.

Abstract: An isolated mammalian internal mammary artery-derived cell is disclosed. Furthermore, methods of isolating the mammalian internal mammary artery-derived cell are disclosed. The cell is useful in tissue engineering technologies, specifically in vascular tissue engineering.

Abstract: The present invention is directed to stabilizing Bone Morphogenetic Protein in various lyophilized formulations and compositions. The present invention comprises formulations primarily including trehalose as an excipient for lyophilized compositions and their subsequent storage and reconstitution, and can also optionally include other excipients, including buffers and surfactants.