Abstract: Mo doped AlCrSiN/Mo self-lubricating films and a preparation method thereof are provided. The AlCrSiN/Mo self-lubricating films are prepared by doping Mo element into the AlCrSiN films, and the Mo content in the resulted films is in the range of 0.3-6.3 at. %. The films are prepared on the substrates by high power impulse magnetron sputtering (HiPIMS) and pulsed DC magnetron sputtering hybrid coating technology. The prepared AlCrSiN/Mo self-lubricating films possess high hardness, good toughness, excellent antifriction characteristics and good chemical stability.

Abstract: An embodiment of this application provides a method and apparatus for testing control software, and a computer-readable storage medium to reduce the time consumed in the simulation-based debugging and enhance efficiency. The method may include obtaining test information of a plurality of fault signals; and injecting, based on the test information of the plurality of fault signals, the plurality of fault signals into a simulation environment in sequence to obtain test results of the plurality of fault signals handled by the control software, where the simulation environment may be a simulation environment of a control object of the control software.

Abstract: An immune molecule virus particle detection kit is provided. A monoclonal antibody of a virus envelope antigen is modified with biotin, magnetic beads are coupled with streptavidin, and the biotin-modified monoclonal antibody is incubated with a virus-containing solution to form a complex with virus particles or antigens, and then the streptavidin-coupled magnetic beads are added for incubation. The streptavidin on the magnetic beads binds with the biotin-modified monoclonal antibody with high specificity and affinity, and then specifically captures the virus particles with envelopes. After separating a supernatant through a magnetic separator, complete viral particles, empty-shell viruses, and free envelope antigens can be separated from other virus components, and the magnetic bead conjugates can be qualitatively or quantitatively detected through polymerase chain reaction (PCR) amplification.

Abstract: The present application relates to a crystalline form of 4-(4-chloroanilino)-7-(2-methylaminocarbonyl-4-oxymethyl)pyridylfuro[2,3-d]pyridazine mesylate (EOC315) that contains crystalline form Mod. I. The present application also relates to a process for the preparation of the crystalline form and the pharmaceutical use of the crystalline form.

Abstract: A crystalline form of Mod. I of Formula I: And, a process for the preparation of the crystalline form and a pharmaceutical use of the crystalline form.

Abstract: A device for passing a biopolymer molecule includes a nanochannel formed between a surface relief structure, a patterned layer forming sidewalls of the nanochannel and a sealing layer formed over the patterned layer to encapsulate the nanochannel. The surface relief structure includes a three-dimensionally rounded surface that reduces a channel dimension of the nanochannel at a portion of nanochannel and gradually increases the dimension along the nanochannel toward an opening position, which is configured to receive a biopolymer.

Abstract: A mechanism is provided for reducing entropy of a polyelectrolyte before the polyelectrolyte moves through a nanopore. A free-standing membrane has the nanopore formed through the membrane. An agarose gel is formed onto either and/or both sides of the nanopore in the membrane. The agarose gel is a porous material. The polyelectrolyte is uncoiled by driving the polyelectrolyte through the porous material of the agarose gel via an electric field. Driving the polyelectrolyte, having been uncoiled and linearized by the agarose gel, into the nanopore is for sequencing.

Abstract: A mechanism is provided for reducing entropy of a polyelectrolyte before the polyelectrolyte moves through a nanopore. A free-standing membrane has the nanopore formed through the membrane. An agarose gel is formed onto either and/or both sides of the nanopore in the membrane. The agarose gel is a porous material. The polyelectrolyte is uncoiled by driving the polyelectrolyte through the porous material of the agarose gel via an electric field. Driving the polyelectrolyte, having been uncoiled and linearized by the agarose gel, into the nanopore is for sequencing.

Abstract: The present application relates to a crystalline form of 4-(4-chloroanilino)-7-(2-methylaminocarbonyl-4-oxymethyl)pyridylfuro[2,3-d]pyridazine mesylate (EOC315) that contains crystalline form Mod. I. The present application also relates to a process for the preparation of the crystalline form and the pharmaceutical use of the crystalline form.

Abstract: A technique includes forming a gradient channel with width and depth gradients. A mask is disposed on top of a substrate. The mask is patterned with at least one elongated channel pattern having different elongated channel pattern widths. A channel is etched in the substrate in a single etching step, the channel having a width gradient and a corresponding depth gradient both simultaneously etched in the single etching step according to the different elongated channel pattern widths in the mask.

Abstract: A battery management system for an electrified powertrain of a hybrid vehicle includes one or more sensors configured to measure voltage, current, and temperature for a battery system of the hybrid vehicle and a controller. The controller is configured to obtain an equivalent circuit model for the battery system, determine a set of states for the battery system to be estimated, determine a set of parameters for the battery system to be estimated, receive, from the sensor(s), the measured voltage, current, and temperature for the battery system, using the equivalent circuit model and the measured voltage, current, and temperature of the battery system, estimate the sets of states and parameters for the battery system using a mixed sigma-point Kalman filtering (SPKF) and recursive least squares (RLS) technique, and using the sets of estimated states/parameters for the battery system, control an electric motor of the electrified vehicle.

Abstract: Techniques for increasing the capture zone in nano and microchannel-based polymer testing structures using concentric arrangements of nanostructures, such as nanopillars are provided. In one aspect, a testing structure for testing polymers is provided that includes a first fluid reservoir and a second fluid reservoir formed in an electrically insulating substrate; at least one channel formed in the insulating substrate that interconnects the first fluid reservoir and the second fluid reservoir; and an arrangement of nanostructures within either the first fluid reservoir or the second fluid reservoir wherein the nanostructures are arranged so as to form multiple concentric circles inside either the first fluid reservoir or the second fluid reservoir with each of the concentric circles being centered at an entry point of the channel. A method of analyzing a polymer using the testing structure is also provided.

Abstract: A technique for a nanodevice is provided. The nanodevice includes a fluidic cell, and a membrane dividing the fluidic cell. A nanopore is formed through the membrane, and the nanopore is coated with an organic compound. A first part of the organic compound binds to a surface of the nanopore and a second part of the organic compound is exposed freely inside of the nanopore. The second part of the organic compound is configured to be switched among a first neutral hydrophilic end group, a second negatively charged hydrophilic end group, and a third neutral hydrophobic end group based on a switching mechanism.

Abstract: A technique for a nanodevice is provided. The nanodevice includes a fluidic cell, and a membrane dividing the fluidic cell. A nanopore is formed through the membrane, and the nanopore is coated with an organic compound. A first part of the organic compound binds to a surface of the nanopore and a second part of the organic compound is exposed freely inside of the nanopore. The second part of the organic compound is configured to be switched among a first neutral hydrophilic end group, a second negatively charged hydrophilic end group, and a third neutral hydrophobic end group based on a switching mechanism.

Abstract: A device for passing a biopolymer molecule includes a nanochannel formed between a surface relief structure, a patterned layer forming sidewalls of the nanochannel and a sealing layer formed over the patterned layer to encapsulate the nanochannel. The surface relief structure includes a three-dimensionally rounded surface that reduces a channel dimension of the nanochannel at a portion of nanochannel and gradually increases the dimension along the nanochannel toward an opening position, which is configured to receive a biopolymer.

Abstract: A battery management system for an electrified powertrain of a hybrid vehicle includes one or more sensors configured to measure voltage, current, and temperature for a battery system of the hybrid vehicle and a controller. The controller is configured to obtain an equivalent circuit model for the battery system, determine a set of states for the battery system to be estimated, determine a set of parameters for the battery system to be estimated, receive, from the sensor(s), the measured voltage, current, and temperature for the battery system, using the equivalent circuit model and the measured voltage, current, and temperature of the battery system, estimate the sets of states and parameters for the battery system using a mixed sigma-point Kalman filtering (SPKF) and recursive least squares (RLS) technique, and using the sets of estimated states/parameters for the battery system, control an electric motor of the electrified vehicle.

Abstract: A wet cell apparatus is provided and includes a sensor body defining a nano-pore by which respective cell interiors are fluidly communicative and a scanning probe microscope (SPM) tip. The SPM tip is configured to draw a molecule through the nano-pore from one of the respective cell interiors whereby sensing components of the sensor body identify molecule components as the molecule passes through the nano-pore.