Patents by Inventor Derek A. Cogan
Derek A. Cogan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240376113Abstract: The present disclosure relates generally to inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions thereof, and methods of using said compounds and compositions thereof. More specifically, the present disclosure relates to triazolopyrimidine and imidazolopyrimidine inhibitors of ENPP1 and methods of their use for treating disease mediated by ENPP1.Type: ApplicationFiled: July 12, 2024Publication date: November 14, 2024Applicant: Volastra Therapeutics, Inc.Inventors: Sarah BETTIGOLE, Michael SU, Derek A. COGAN, Leon VAN BERKOM, Piotr NIECZYPOR, Gydo VAN DER HEIJDEN, Prashanna VIJAYACHANDRAN
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Publication number: 20240351984Abstract: The present disclosure relates generally to inhibitors of KIF18A, compositions thereof, and methods of using said compounds and compositions thereof. More specifically, the present disclosure relates to indoline inhibitors of KIF18A and methods of their use for treating disease mediated by KIF18A, such as cancer.Type: ApplicationFiled: June 5, 2024Publication date: October 24, 2024Applicant: Volastra Therapeutics, Inc.Inventor: Derek A. COGAN
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Patent number: 12091412Abstract: The present disclosure relates generally to inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions thereof, and methods of using said compounds and compositions thereof. More specifically, the present disclosure relates to triazolopyrimidine and imidazolopyrimidine inhibitors of ENPP1 and methods of their use for treating disease mediated by ENPP1.Type: GrantFiled: June 15, 2021Date of Patent: September 17, 2024Assignee: Volastra Therapeutics, Inc.Inventors: Sarah Bettigole, Michael Su, Derek A. Cogan, Leon Van Berkom, Piotr Nieczypor, Gydo Van Der Heijden, Prashanna Vijayachandran
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Patent number: 12084420Abstract: The present disclosure relates generally to inhibitors of KIF18A, compositions thereof, and methods of using the compounds and compositions thereof. More specifically, the present disclosure relates to indoline inhibitors of KIF18A and methods of their use for treating disease mediated by KIF18A, such as cancer.Type: GrantFiled: August 25, 2022Date of Patent: September 10, 2024Assignee: Volastra Therapeutics, Inc.Inventor: Derek A. Cogan
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Publication number: 20230382889Abstract: The present disclosure relates generally to inhibitors of KIF18A, compositions thereof, and methods of using said compounds and compositions thereof. More specifically, the present disclosure relates to inhibitors of KIF18A and methods of their use for treating disease mediated by KIF18A, such as cancer.Type: ApplicationFiled: April 27, 2023Publication date: November 30, 2023Applicant: Volastra Therapeutics, Inc.Inventor: Derek A. COGAN
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Patent number: 11780849Abstract: The present disclosure relates generally to inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions thereof, and methods of using said compounds and compositions thereof. More specifically, the present disclosure relates to sulfoximine-based inhibitors of ENPP1 and methods of their use for treating disease mediated by ENPP1.Type: GrantFiled: May 3, 2021Date of Patent: October 10, 2023Assignee: Volastra Therapeutics, Inc.Inventors: Derek A. Cogan, Sarah Bettigole, Leon Van Berkom, Piotr Nieczypor, Michael Su, Rutger Folmer
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Publication number: 20230147507Abstract: The present disclosure relates generally to inhibitors of KIF18A, compositions thereof, and methods of using said compounds and compositions thereof. More specifically, the present disclosure relates to indoline inhibitors of KIF18A and methods of their use for treating disease mediated by KIF18A, such as cancer.Type: ApplicationFiled: August 25, 2022Publication date: May 11, 2023Applicant: Volastra Therapeutics, Inc.Inventor: Derek A. COGAN
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Publication number: 20230036933Abstract: The present disclosure relates generally to inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions thereof, and methods of using said compounds and compositions thereof. More specifically, the present disclosure relates to triazolopyrimidine and imidazolopyrimidine inhibitors of ENPP1 and methods of their use for treating disease mediated by ENPP1.Type: ApplicationFiled: June 15, 2021Publication date: February 2, 2023Applicant: Volastra Therapeutics, Inc.Inventors: Sarah BETTIGOLE, Michael SU, Derek A. COGAN, Leon VAN BERKOM, Piotr NIECZYPOR, Gydo VAN DER HEIJDEN, Prashanna VIJAYACHANDRAN
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Publication number: 20230002406Abstract: The present disclosure relates generally to inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions thereof, and methods of using said compounds and compositions thereof. More specifically, the present disclosure relates to sulfoximine-based inhibitors of ENPP1 and methods of their use for treating disease mediated by ENPP1.Type: ApplicationFiled: May 3, 2021Publication date: January 5, 2023Applicant: Volastra Therapeutics, Inc.Inventors: Derek A. COGAN, Sarah BETTIGOLE, Leon VAN BERKOM, Piotr NIECZYPOR, Michael SU, Rutger FOLMER
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Patent number: 7569568Abstract: Disclosed are compounds of formula (I) Where Ar1, X, R3, R4, R5 and R6 are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.Type: GrantFiled: September 7, 2006Date of Patent: August 4, 2009Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Derek A. Cogan, Ming-Hong Hao, Kevin Chungeng Qian, Alan David Swinamer
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Patent number: 7166628Abstract: Disclosed are compounds of formula (I) Where Ar1, X, R3, R4, R5 and R6 are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.Type: GrantFiled: November 20, 2003Date of Patent: January 23, 2007Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Derek A. Cogan, Ming-Hong Hao, Kevin Chungeng Qian, Alan David Swinamer
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Publication number: 20040102492Abstract: Disclosed are compounds of formula (I) 1Type: ApplicationFiled: November 20, 2003Publication date: May 27, 2004Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Derek A. Cogan, Ming-Hong Hao, Kevin Chungeng Qian, Alan David Swinamer
