Patents by Inventor Derek A. Hollingsbee
Derek A. Hollingsbee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6613325Abstract: In accordance with the present invention it has been found that a fibrin polymer film formed by applying materials most closely resembling the natural clotting materials to a surgical adhesion formation. Preferred embodiments involve application of a fibrin monomer under polymerizing conditions to the surgical wound site. Unexpectedly, in addition to this improved prevention of adhesions, the more chemically-natural clots, especially the fibrin-monomer based fibrin polymer, also functions as a fibrin sealant, i.e., has adherence, provides hemostasis and promotes wound healing while also functioning as a barrier. In preferred embodiments the novel methods of this invention conveniently use one or more plasma proteins derived from the patient's own blood as to be autologous. Further, the sealant material is preferably substantially free of any added or exogenous enzymes, e.g., thrombin, etc., which catalyze the cleavage of fibrinopeptides A and/or B from fibrinogen.Type: GrantFiled: June 1, 2000Date of Patent: September 2, 2003Assignee: Bristol-Myers Squibb CompanyInventors: Michael J. Amery, Paul Sibbons, Stuart Burnett, Sally-Anne Rickets, Peter A. D. Edwardson, Jonathan Hughes, Derek A. Hollingsbee, Stewart A. Cederholm-Williams, Horace R. Trumbull, Herman Eugene Griffin
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Patent number: 6558687Abstract: In accordance with the present invention a novel fibrin polymer structure is disclosed. The novel fibrin polymer structure useful, for example, as a surgical sealant, is comprised of a plurality of discrete, droplets of polymerizing or polymerized fibrin each encapsulated by a “skin” of fibrin polymer. These fibrin-skin encapsulated droplets are applied so as to be built up one upon the other, layer by layer, to form an integral sealant structure. The cumulative effect of the encapsulating skins of those droplets which form the sealant surface is a surface skin which unexpectedly resists cell penetration but enhances cell migration across the surface. The sealant structure of the present invention can be prepared by spray delivery of fibrin polymer forming materials wherein the time required for the materials to commence polymerizing after mixing is less than or equal to the transit time of said materials from the applicator tip to the target surface.Type: GrantFiled: November 29, 2001Date of Patent: May 6, 2003Assignee: Bristol-Myers Squibb CompanyInventors: Stewart A. Cederholm-Williams, Julian M. Marshall, Jose L. Velada, Derek A. Hollingsbee
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Publication number: 20020160508Abstract: In accordance with the present invention a novel fibrin polymer structure is disclosed. The novel fibrin polymer structure useful, for example, as a surgical sealant, is comprised of a plurality of discrete, droplets of polymerizing or polymerized fibrin each encapsulated by a “skin” of fibrin polymer. These fibrin-skin encapsulated droplets are applied so as to be built up one upon the other, layer by layer, to form an integral sealant structure. The cumulative effect of the encapsulating skins of those droplets which form the sealant surface is a surface skin which unexpectedly resists cell penetration but enhances cell migration across the surface. The sealant structure of the present invention can be prepared by spray delivery of fibrin polymer forming materials wherein the time required for the materials to commence polymerizing after mixing is less than or equal to the transit time of said materials from the applicator tip to the target surface.Type: ApplicationFiled: November 29, 2001Publication date: October 31, 2002Inventors: Stewart A. Cederholm-Williams, Julian M. Marshall, Jose L. Velada, Derek A. Hollingsbee
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Publication number: 20020150611Abstract: In accordance with the present invention a novel fibrin polymer structure is disclosed. The novel fibrin polymer structure useful, for example, as a surgical sealant, is comprised of a plurality of discrete, droplets of polymerizing or polymerized fibrin each encapsulated by a “skin” of fibrin polymer. These fibrin-skin encapsulated droplets are applied so as to be built up one upon the other, layer by layer, to form an integral sealant structure. The cumulative effect of the encapsulating skins of those droplets which form the sealant surface is a surface skin which unexpectedly resists cell penetration but enhances cell migration across the surface. The sealant structure of the present invention can be prepared by spray delivery of fibrin polymer forming materials wherein the time required for the materials to commence polymerizing after mixing is less than or equal to the transit time of said materials from the applicator tip to the target surface.Type: ApplicationFiled: November 29, 2001Publication date: October 17, 2002Inventors: Stewart A. Cederholm-Williams, Julian M. Marshall, Jose L. Velada, Derek A. Hollingsbee
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Patent number: 6462018Abstract: In accordance with the present invention a novel fibrin polymer structure is disclosed. The novel fibrin polymer structure useful, for example, as a surgical sealant, is comprised of a plurality of discrete, droplets of polymerizing or polymerized fibrin each encapsulated by a “skin” of fibrin polymer. These fibrin-skin encapsulated droplets are applied so as to be built up one upon the other, layer by layer, to form an integral sealant structure. The cumulative effect of the encapsulating skins of those droplets which form the sealant surface is a surface skin which unexpectedly resists cell penetration but enhances cell migration across the surface. The sealant structure of the present invention can be prepared by spray delivery of fibrin polymer forming materials wherein the time required for the materials to commence polymerizing after mixing is less than or equal to the transit time of said materials from the applicator tip to the target surface.Type: GrantFiled: June 1, 2000Date of Patent: October 8, 2002Assignee: Bristol-Myers Squibb CompanyInventors: Stewart A. Cederholm-Williams, Julian M. Marshall, Jose L. Velada, Derek A. Hollingsbee
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Patent number: 6268483Abstract: Novel fibrin monomer compositions which are solutions including additional coharvested components, such as prothrombin and Factor XIII, are useful in fibrin sealant applications. Preferably, the compositions are autologous to the patient receiving the sealant and these compositions may also include coharvested plasminogen, Factor X, antithrombin III and/or fibronectin.Type: GrantFiled: June 9, 1998Date of Patent: July 31, 2001Assignee: Bristol-Myers Squibb CompanyInventors: Peter A. D. Edwardson, John E. Fairbrother, Ronald S. Gardner, Derek A. Hollingsbee, Stewart A. Cederholm-Williams
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Patent number: 6262236Abstract: The subject invention relates to fibrin sealants. More specifically, the subject invention relates to the use of a fibrin sealant wherein a composition comprising fibrin monomer or a composition comprising noncrosslinked fibrin is utilized as a component of the fibrin sealant.Type: GrantFiled: February 28, 2000Date of Patent: July 17, 2001Assignee: Bristol-Myers Squibb CompanyInventors: Peter A. D. Edwardson, John E. Fairbrother, Ronald S. Gardner, Derek A. Hollingsbee, Stewart A. Cederholm-Williams
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Patent number: 6077507Abstract: The subject invention relates to fibrin sealants. More specifically, the subject invention relates to the use of a fibrin sealant wherein a composition comprising fibrin monomer or a composition comprising noncrosslinked fibrin is utilized as a component of the fibrin sealant.Type: GrantFiled: March 26, 1997Date of Patent: June 20, 2000Assignee: Bristol-Myers Squibb CompanyInventors: Peter A. D. Edwardson, John E. Fairbrother, Ronald S. Gardner, Derek A. Hollingsbee, Stewart A. Cederholm-Williams
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Patent number: 6048966Abstract: The subject invention relates to fibrin sealants. More specifically, the subject invention relates to the use of a fibrin sealant wherein a composition comprising fibrin monomer or a composition comprising noncrosslinked fibrin is utilized as a component of the fibrin sealant.Type: GrantFiled: December 23, 1997Date of Patent: April 11, 2000Assignee: Bristol-Myers Squibb CompanyInventors: Peter A. D. Edwardson, John E. Fairbrother, Ronald S. Gardner, Derek A. Hollingsbee, Stewart A. Cederholm-Williams
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Patent number: 5962026Abstract: This invention is directed to solid compositions, for example, lyophilized forms, of fibrin monomer. These compositions are useful wherever fibrin monomer could be employed, e.g., as a surgical sealant to provide hemostasis.Type: GrantFiled: May 31, 1995Date of Patent: October 5, 1999Assignee: Bristol-Myers Squibb CompanyInventors: Peter A. D. Edwardson, John E. Fairbrother, Ronald S. Gardner, Derek A. Hollingsbee, Stewart A. Cederholm-Williams
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Patent number: 5962420Abstract: The subject invention relates to fibrin sealants. More specifically, the subject invention relates to the use of a fibrin sealant wherein a composition comprising fibrin monomer or a composition comprising noncrosslinked fibrin is utilized as a component of the fibrin sealant.Type: GrantFiled: April 13, 1998Date of Patent: October 5, 1999Assignee: Bristol-Myers Squibb CompanyInventors: Peter A. D. Edwardson, John E. Fairbrother, Ronald S. Gardner, Derek A. Hollingsbee, Stewart A. Cederholm-Williams
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Patent number: 5804428Abstract: The invention relates to fibrin sealants. More specifically, the invention relates to the preparation of a fibrin polymer wherein the polymer is substantially free of the enzyme.Type: GrantFiled: March 31, 1998Date of Patent: September 8, 1998Assignee: Bristol-Myers Squibb CompanyInventors: Peter A. D. Edwardson, John E. Fairbrother, Ronald S. Gardner, Derek A. Hollingsbee, Stewart A. Cederholm-Williams
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Patent number: 5773418Abstract: The subject invention relates to fibrin sealants. More specifically, the subject invention relates to the use of a fibrin sealant wherein a composition comprising fibrin monomer or a composition comprising noncrosslinked fibrin is utilized as a component of the fibrin sealant.Type: GrantFiled: November 20, 1997Date of Patent: June 30, 1998Assignee: Bristol-Myers Squibb CompanyInventors: Peter A. D. Edwardson, John E. Fairbrother, Ronald S. Gardner, Derek A. Hollingsbee, Stewart A. Cederholm-Williams
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Patent number: 5770194Abstract: The subject invention relates to fibrin sealants. More specifically, the subject invention relates to the use of a fibrin sealant wherein a composition comprising fibrin polymer is utilized as a component of the fibrin sealant.Type: GrantFiled: May 25, 1995Date of Patent: June 23, 1998Assignee: Bristol-Myers Squibb CompanyInventors: Peter A. D. Edwardson, John E. Fairbrother, Ronald S. Gardner, Derek A. Hollingsbee, Stewart A. Cederholm-Williams
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Patent number: 5763410Abstract: Novel kits for the preparation of a fibrin sealant are disclosed. In one kit a first component is fibrin monomer which can be polymerized to form a fibrin sealant when combined with the second component which is distilled water or an alkaline buffer.Type: GrantFiled: June 2, 1995Date of Patent: June 9, 1998Assignee: Bristol-Myers Squibb CompanyInventors: Peter A. D. Edwardson, John E. Fairbrother, Ronald S. Gardner, Derek A. Hollingsbee, Stewart A. Cederholm-Williams
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Patent number: 5763411Abstract: The present invention relates to a solid support, e.g., a suture, bandage, dressing or prosthesis, and a nondynamic fibrin monomer. The nondynamic fibrin monomer is readily capable of being converted to a fibrin polymer which has sealant and hemostasis properties.Type: GrantFiled: June 2, 1995Date of Patent: June 9, 1998Assignee: Bristol-Myers Squibb CompanyInventors: Peter A. D. Edwardson, John E. Fairbrother, Ronald S. Gardner, Derek A. Hollingsbee, Stewart A. Cederholm-Williams
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Patent number: 5750657Abstract: The subject invention relates to methods and compositions using nondynamic fibrin monomer which is selectively converted to a fibrin polymer which serves as the fibrin sealant.Type: GrantFiled: October 18, 1993Date of Patent: May 12, 1998Assignee: Bristol-Myers Squibb CompanyInventors: Peter A. D. Edwardson, John E. Fairbrother, Ronald S. Gardner, Derek A. Hollingsbee, Stewart A. Cederholm-Williams
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Patent number: 5739288Abstract: The invention relates to fibrin sealants. More specifically, the invention relates to the use of a fibrin sealant wherein a composition comprising fibrin monomer or a composition comprising noncrosslinked fibrin is utilized as a component of the fibrin sealant.Type: GrantFiled: May 26, 1995Date of Patent: April 14, 1998Assignee: Bristol-Myers Squibb CompanyInventors: Peter A. D. Edwardson, John E. Fairbrother, Ronald S. Gardner, Derek A. Hollingsbee, Stewart A. Cederholm-Williams
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Patent number: 4421741Abstract: An anti-inflammatory pharmaceutical composition is described which is adapted for topical application to the eye and contains as active principle a compound of formula ##STR1## or a pharmaceutically acceptable salt thereof where R.sub.1 is a chlorine atom or a methyl group, R.sub.2 is a hydrogen atom or a methyl group and R.sub.3 is a hydrogen atom or a methyl group. The composition may be used to treat ocular inflammation.Type: GrantFiled: June 9, 1982Date of Patent: December 20, 1983Assignee: Smith and Nephew Associated Companies LimitedInventors: David J. Gilbert, Derek A. Hollingsbee
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Patent number: 4349563Abstract: An anti-inflammatory pharmaceutical composition is described which is adapted for topical application to the eye and contains as active principle a compound of formula ##STR1## or a pharmaceutically acceptable salt thereof where R.sub.1 is a chlorine atom or a methyl group, R.sub.2 is a hydrogen atom or a methyl group and R.sub.3 is a hydrogen atom or a methyl group. The composition may be used to treat ocular inflammation.Type: GrantFiled: April 13, 1981Date of Patent: September 14, 1982Assignee: Smith and Nephew Associated Companies LimitedInventors: David J. Gilbert, Derek A. Hollingsbee