Patents by Inventor Derek A. Mann

Derek A. Mann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of inhibiting fibrogenesis and treating fibrotic disease
    Patent number: 8642602
    Abstract: The present invention relates to the discovery of an epigenetic relay pathway that controls hepatic stellate cell activation and the wound-healing response in fibrogenesis, including fibrogenesis of the injured liver. Methods of inhibiting fibrogenesis, including liver fibrogenesis and secondary disease states and conditions thereof, and in treating liver damage, including cirrhosis of the liver (which may be caused by viruses or chemicals, including alcohol), are aspects of the present invention. The methods utilize certain nucleoside compounds and/or antibodies which are optionally conjugated. Pharmaceutical compositions represent additional aspects of the invention.
    Type: Grant
    Filed: February 2, 2010
    Date of Patent: February 4, 2014
    Assignees: University of Georgia Research Foundation, Inc., University of Newcastle Upon Tyne
    Inventors: Jelena Mann, Chung K. Chu, Derek A. Mann
  • METHOD OF INHIBITING FIBROGENESIS AND TREATING FIBROTIC DISEASE
    Publication number: 20120014962
    Abstract: The present invention relates to the discovery of an epigenetic relay pathway that controls hepatic stellate cell activation and the wound-healing response in fibrogenesis, including fibrogenesis of the injured liver. Methods of inhibiting fibrogenesis, including liver fibrogenesis and secondary disease states and conditions thereof, and in treating liver damage, including cirrhosis of the liver (which may be caused by viruses or chemicals, including alcohol), are aspects of the present invention. The methods utilize certain nucleoside compounds and/or antibodies which are optionally conjugated. Pharmaceutical compositions represent additional aspects of the invention.
    Type: Application
    Filed: February 2, 2010
    Publication date: January 19, 2012
    Applicants: University of Newcastle Upon Tyne, University of Georgia Research Foundation, Inc.
    Inventors: Jelena Mann, Chung K. Chu, Derek A. Mann