Abstract: The invention provides a delivery device (10) for a medicament comprising: a housing (50), a receptacle (54) holding a medicament (80) in the form of a powder; and a source of propellant (53), characterized in that the housing (50) provides an inlet (63) and an outlet (56) for the receptacle (54) wherein the inlet (63) is in fluid communication with the source of propellant (53) and is directed against the medicament (80) and the outlet (56) is spaced from the medicament (80) to allow aerosolisation of the medicament (80); the device (10) provides improved delivery efficiency, particularly a delivered fine particle fraction of greater than 20% by weight.

Abstract: The application describes apparatus and methods for delivering a powdered medicament for inhalation. The medicament is put in a receptacle (100) on a vibration generator (80) operated by fluid pressure, e.g. by means of an eccentric rotor. A flow of gas from a supply (20) is passed into the receptacle (100), producing in concert with the vibration an aerosol which passes out of the receptacle and along a tube (110) to be inhaled by the patient. Both the gas flow supply and vibration may be subject to the operation of a control unit (60), which may time the production of the aerosol according to a patient's breathing cycle, e.g. as part of a ventilator system.

Abstract: A phospholipid comprising a diacyl-substituted phosphatidyl group and a pharmaceutical composition comprising such a phospholipid for use in treatment of an allergic inflammatory condition and a method for the treatment of an allergic inflammatory condition. The phospholipid is particularly a mixture of phospholipids known as pumactant.

Abstract: A method and apparatus are disclosed for treating asthma and other respiratory conditions. A medicament comprising a surface active phospholipid (SAPL) is prepared in the form of a fine powder and administered to the lungs in a gas stream. A preferred SAPL is a solid blend of diplamitoyl choline and phosphatdiyl glycerol (PG).

Abstract: Disclosed is a combination product for use in treating asthma and other respiratory conditions comprising a medicament comprising a surface active phospholipid composition in the form of a fine powder and an antiasthma drug. The product is arranged to be administered to the lungs by inhalation, for example, by the disclosed devices.

Abstract: Disclosed is a combination product for use in treating asthma and other respiratory conditions comprising a medicament comprising a surface active phospholipid composition in the form of a fine powder and an antiasthma drug. The product is arranged to be administered to the lungs by inhalation, for example, by the disclosed devices.

Abstract: A medicament is disclosed for reducing the risk of cross-healing (“adhesions”) after surgery. The medicament is a dry powder comprising a surface active phospholipid which is capable of binding to mesothical membranes, and a spreading agent. The medicament is applied as a dry powder to the surgical wound site.

Abstract: A method and apparatus are disclosed for treating asthma and other respiratory conditions. A medicament comprising a surface active phospholipid (SAPL) is prepared in the form of a fine powder and administered to the lungs in a gas stream. A preferred SAPL is a solid blend of diplamitoyl choline and phosphatdiyl glycerol (PG).

Abstract: A method and apparatus is disclosed for treating asthma and other respiratory conditions. A medicament comprising a surface active phospholipid (SAPL) is prepared in the form of a fine powder and administered to the lungs in a gas stream. A preferred SAPL is a solid blend of dipalmitoyl phosphatidyl choline (DPPC) and phosphatidyl glycerol (PG).

Abstract: The invention relates to the treatment of serous otitis media (glue ear). A medicament is disclosed which comprises a surface active phospholipid (SAPL) which is instilled as a powder into the middle ear. The SAPL has an affinity for the surface of the Eustachian tube and forms a film over its surface which prevents or deters reblockage of the tube.