Patents by Inventor Derek BUSH

Derek BUSH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid or semisolid lipid based dosage form stabilization through curing and addition of low HLB surfactant(s)
    Patent number: 12544338
    Abstract: Disclosed herein are dosage forms comprise a solid or a semisolid lipid with immediate release properties and/or with extended release properties. The dosage forms disclosed herein may have their active pharmaceutical ingredient's (API's) release profile stabilized via curing and/or via the addition of a surfactant with an HLB value of less than 10.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: February 10, 2026
    Assignee: R.P. SCHERER TECHNOLOGIES, LLC
    Inventors: Monica Lazaro, Irena McGuffy, Derek Bush, Linus Gomsi Fonkwe
  • METHOD OF TREATMENT OF SYMPTOMS OF MENOPAUSE
    Publication number: 20250154167
    Abstract: The present invention generally relates to novel pharmaceutical formulations containing 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4] oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide, methods of preparation thereof and their use in medical therapy.
    Type: Application
    Filed: January 16, 2025
    Publication date: May 15, 2025
    Applicant: KaNDy Therapeutics Limited
    Inventors: Mike TROWER, Monica LAZARO, Derek BUSH, David ELDER, Mary KERR
  • Method of treatment of symptoms of menopause
    Patent number: 12264164
    Abstract: The present invention generally relates to novel pharmaceutical formulations containing 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl) hexahydropyrazino [2,1-c] [1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide, methods of preparation thereof and their use in medical therapy.
    Type: Grant
    Filed: July 31, 2023
    Date of Patent: April 1, 2025
    Assignee: KANDY THERAPEUTICS LIMITED
    Inventors: Mike Trower, Monica Lazaro, Derek Bush, David Elder, Mary Kerr
  • METHOD OF TREATMENT OF SYMPTOMS OF MENOPAUSE
    Publication number: 20230382922
    Abstract: The present invention generally relates to novel pharmaceutical formulations containing 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl) hexahydropyrazino [2,1-c] [1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide, methods of preparation thereof and their use in medical therapy.
    Type: Application
    Filed: July 31, 2023
    Publication date: November 30, 2023
    Applicant: KaNDy Therapeutics Limited
    Inventors: Mike TROWER, Monica LAZARO, Derek BUSH, David ELDER, Mary KERR
  • Method of treating certain sex hormone-dependent diseases administering a soft gelatin capsule comprising NK1 and NK3 receptors antagonists
    Patent number: 11787820
    Abstract: The present invention generally relates to novel pharmaceutical formulations containing 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide, methods of preparation thereof and their use in medical therapy.
    Type: Grant
    Filed: August 4, 2020
    Date of Patent: October 17, 2023
    Assignee: KaNDy Therapeutics Limited
    Inventors: Mike Trower, Monica Lazaro, Derek Bush, David Elder, Mary Kerr
  • Method of treatment of symptoms of menopause
    Patent number: 11767328
    Abstract: The present invention generally relates to novel pharmaceutical formulations containing 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide, methods of preparation thereof and their use in medical therapy.
    Type: Grant
    Filed: January 13, 2023
    Date of Patent: September 26, 2023
    Assignee: KaNDy Therapeutics Limited
    Inventors: Mike Trower, Monica Lazaro, Derek Bush, David Elder, Mary Kerr
  • METHOD OF TREATMENT OF SYMPTOMS OF MENOPAUSE
    Publication number: 20230174552
    Abstract: The present invention generally relates to novel pharmaceutical formulations containing 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide, methods of preparation thereof and their use in medical therapy.
    Type: Application
    Filed: January 13, 2023
    Publication date: June 8, 2023
    Applicant: KaNDy Therapeutics Limited
    Inventors: Mike TROWER, Monica LAZARO, Derek BUSH, David ELDER, Mary KERR
  • Method of treatment of symptoms of menopause
    Patent number: 11591346
    Abstract: The present invention generally relates to novel pharmaceutical formulations containing 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide, methods of preparation thereof and their use in medical therapy.
    Type: Grant
    Filed: August 4, 2020
    Date of Patent: February 28, 2023
    Assignee: KaNDy Therapeutics Limited
    Inventors: Mike Trower, Monica Lazaro, Derek Bush, David Elder, Mary Kerr
  • SOLID OR SEMISOLID LIPID BASED DOSAGE FORM STABILIZATION THROUGH CURING AND ADDITION OF LOW HLB SURFACTANT(S)
    Publication number: 20210308062
    Abstract: Disclosed herein are dosage forms comprise a solid or a semisolid lipid with immediate release properties and/or with extended release properties. The dosage forms disclosed herein may have their active pharmaceutical ingredient's (API's) release profile stabilized via curing and/or via the addition of a surfactant with an HLB value of less than 10.
    Type: Application
    Filed: September 9, 2019
    Publication date: October 7, 2021
    Inventors: Monica Lazaro, Irena McGuffy, Derek Bush, Linus Gomsi Fonkwe
  • METHOD OF TREATING CERTAIN SEX HORMONE-DEPENDENT DISEASES ADMINISTERING A SOFT GELATIN CAPSULE COMPRISING NK1 AND NK3 RECEPTORS ANTAGONISTS
    Publication number: 20200361957
    Abstract: The present invention generally relates to novel pharmaceutical formulations containing 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide, methods of preparation thereof and their use in medical therapy.
    Type: Application
    Filed: August 4, 2020
    Publication date: November 19, 2020
    Applicant: KaNDy Therapeutics Limited
    Inventors: Mike Trower, Monica Lazaro, Derek Bush, David Elder, Mary Kerr
  • METHOD OF TREATMENT OF SYMPTOMS OF MENOPAUSE
    Publication number: 20200361956
    Abstract: The present invention generally relates to novel pharmaceutical formulations containing 2-[3,5-Bis (trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide, methods of preparation thereof and their use in medical therapy.
    Type: Application
    Filed: August 4, 2020
    Publication date: November 19, 2020
    Applicant: KaNDy Therapeutics Limited
    Inventors: Mike Trower, Monica Lazaro, Derek Bush, David Elder, Mary Kerr
  • Soft gelatin capsule formulation
    Patent number: 10774091
    Abstract: The present invention generally relates to novel pharmaceutical formulations containing 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide, methods of preparation thereof and their use in medical therapy.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: September 15, 2020
    Assignee: KaNDy Therapeutics Limited
    Inventors: Mike Trower, Monica Lazaro, Derek Bush, David Elder, Mary Kerr
  • NOVEL PHARMACEUTICAL FORMULATION
    Publication number: 20190284205
    Abstract: The present invention generally relates to novel pharmaceutical formulations containing 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide, methods of preparation thereof and their use in medical therapy.
    Type: Application
    Filed: March 13, 2019
    Publication date: September 19, 2019
    Applicant: KaNDy Therapeutics Limited
    Inventors: Mike Trower, Monica Lazaro, Derek Bush, David Elder, Mary Kerr
  • Silk-based capsules
    Patent number: 10182991
    Abstract: A hard or soft capsule is disclosed comprising a shell and a fill material, wherein the shell comprises an interpenetrating network comprising a silk polymer and a film-forming natural polymer. A method of making a hard or soft capsule is also disclosed, comprising dissolving a silk protein in a solvent system to form a solubilized silk protein solution; mixing the solubilized silk protein solution with a film-forming natural polymer to form a homogenous shell material; and encapsulating a fill material with the homogenous shell material.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: January 22, 2019
    Assignee: Patheon Softgels Inc.
    Inventors: Tatyana Dyakonov, Derek Bush, Saujanya L. Gosangari, Chue Hue Yang, Shingai Majuru, Aqeel Fatmi
  • SILK-BASED CAPSULES
    Publication number: 20180235892
    Abstract: A hard or soft capsule is disclosed comprising a shell and a fill material, wherein the shell comprises an interpenetrating network comprising a silk polymer and a film-forming natural polymer. A method of making a hard or soft capsule is also disclosed, comprising dissolving a silk protein in a solvent system to form a solubilized silk protein solution; mixing the solubilized silk protein solution with a film-forming natural polymer to form a homogenous shell material; and encapsulating a fill material with the homogenous shell material.
    Type: Application
    Filed: April 23, 2018
    Publication date: August 23, 2018
    Inventors: Tatyana DYAKONOV, Derek BUSH, Saujanya L. GOSANGARI, Chue Hue YANG, Shingai MAJURU, Aqeel FATMI
  • Silk-based capsules
    Patent number: 9968561
    Abstract: A hard or soft capsule is disclosed comprising a shell and a fill material, wherein the shell comprises an interpenetrating network comprising a silk polymer and a film-forming natural polymer. A method of making a hard or soft capsule is also disclosed, comprising dissolving a silk protein in a solvent system to form a solubilized silk protein solution; mixing the solubilized silk protein solution with a film-forming natural polymer to form a homogenous shell material; and encapsulating a fill material with the homogenous shell material.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 15, 2018
    Assignee: Patheon Softgels Inc.
    Inventors: Tatyana Dyakonov, Derek Bush, Saujanya L. Gosangari, Yang Hue Chue, Shingai Majuru, Aqeel Fatmi
  • SILK-BASED CAPSULES
    Publication number: 20160045443
    Abstract: A hard or soft capsule is disclosed comprising a shell and a fill material, wherein the shell comprises an interpenetrating network comprising a silk polymer and a film-forming natural polymer. A method of making a hard or soft capsule is also disclosed, comprising dissolving a silk protein in a solvent system to form a solubilized silk protein solution; mixing the solubilized silk protein solution with a film-forming natural polymer to form a homogenous shell material; and encapsulating a fill material with the homogenous shell material.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 18, 2016
    Inventors: Tatyana DYAKONOV, Derek BUSH, Saujanya L. GOSANGARI, Yang Hue CHUE, Shingai MAJURU, Aqeel FATMI