Patents by Inventor Derek C. Cole

Derek C. Cole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic Sulfonamide Inhibitors of Beta Amyloid Production
    Publication number: 20110034513
    Abstract: Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof. Methods of using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's disease and Down's syndrome are described.
    Type: Application
    Filed: October 19, 2010
    Publication date: February 10, 2011
    Applicants: Wyeth LLC, ArQule, Inc.
    Inventors: Anthony F. Kreft, Derek C. Cole, Kevin R. Woller, Joseph R. Stock, George Diamantidis, Dennis M. Kubrak, Kristina M. Kutterer, William J. Moore, David S. Casebier
  • Heterocyclic sulfonamide inhibitors of ? amyloid production
    Patent number: 7691884
    Abstract: Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof. Methods of using these compounds for determining ?-amyloid levels in a subject are described.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: April 6, 2010
    Assignees: Wyeth, ArQule, Inc.
    Inventors: Anthony Frank Kreft, Derek C. Cole, Kevin R. Woller, Joseph R. Stock, George Diamantidis, Dennis M. Kubrak, Kristina M. Kutterer, William J. Moore, David S. Casebier
  • Heterocyclic sulfonamide inhibitors of beta amyloid production
    Patent number: 6878742
    Abstract: Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof.
    Type: Grant
    Filed: June 5, 2003
    Date of Patent: April 12, 2005
    Assignees: Wyeth, ArQule, Inc.
    Inventors: Anthony F. Kreft, Derek C. Cole, Kevin R. Woller, Joseph R. Stock, George Diamantidis, Dennis M. Kubrak, Kristina M. Kutterer, William J. Moore, David S. Casebier
  • Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and TACE inhibitors
    Patent number: 6825354
    Abstract: Compounds of the formula are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: November 30, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy I. Levin, Aranapakam M. Venkatesan, Derek C. Cole, James M. Chen, Jamie M. Davis, George T. Grosu
  • Acetylenic &agr;-amino acid-based sulfonamide hydroxamic acid tace inhibitors
    Patent number: 6812227
    Abstract: Compounds of the formula: are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: November 2, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy I. Levin, James M. Chen, Derek C. Cole, Mila T. Du, Leif M. Laakso
  • Acetylenic &agr;-amino acid-based sulfonamide hydroxamic acid tace inhibitors
    Patent number: 6716833
    Abstract: Compounds of the formula: are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: April 6, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy I. Levin, James M. Chen, Derek C. Cole, Mila T. Du, Leif M. Laakso
  • Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors
    Publication number: 20040033988
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: February 27, 2003
    Publication date: February 19, 2004
    Applicant: Wyeth
    Inventors: Jeremy I. Levin, James M. Chen, Derek C. Cole, Mila T. Du, Leif M. Laakso
  • Heterocyclic sulfonamide inhibitors of beta amyloid production
    Publication number: 20030229127
    Abstract: Compounds of Formula (I), 1
    Type: Application
    Filed: June 5, 2003
    Publication date: December 11, 2003
    Applicants: Wyeth, ArQule Inc.
    Inventors: Anthony F. Kreft, Derek C. Cole, Kevin R. Woller, Joseph R. Stock, George Diamantidis, Dennis M. Kubrak, Kristina M. Kutterer, William J. Moore, David S. Casebier
  • Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors
    Publication number: 20030212049
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: February 27, 2003
    Publication date: November 13, 2003
    Applicant: Wyeth
    Inventors: Jeremy I. Levin, James Ming Chen, Derek C. Cole, Mila T. Du, Leif M. Laakso
  • Heterocyclic sulfonamide inhibitors of beta amyloid production
    Patent number: 6610734
    Abstract: Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof. Methods of using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are described.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: August 26, 2003
    Assignees: Wyeth, ArQule Inc.
    Inventors: Anthony F. Kreft, Derek C. Cole, Kevin R. Woller, Joseph R. Stock, George Diamantidis, Dennis M. Kubrak, Kristina M. Kutterer, William J. Moore, David S. Casebier, Lynn Resnick
  • Acetylenic alpha -amino acid-based sulfonamide hydroxamic acid tace inhibitors
    Publication number: 20030008849
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: December 27, 2000
    Publication date: January 9, 2003
    Inventors: Jeremy I. Levin, James M. Chen, Derek C. Cole, Mila T. Du, Leif M. Laakso
  • Heterocyclic sulfonamide inhibitors of beta amyloid production
    Publication number: 20020183361
    Abstract: Compounds of Formula (I), 1
    Type: Application
    Filed: December 11, 2001
    Publication date: December 5, 2002
    Applicant: ArQule
    Inventors: Anthony F. Kreft, Derek C. Cole, Kevin R. Woller, Joseph R. Stock, George Diamantidis, Dennis M. Kubrak, Kristina M. Kutterer, William J. Moore, David S. Casebier
  • Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors
    Publication number: 20020147342
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: November 13, 2001
    Publication date: October 10, 2002
    Applicant: American Cyanamid Company
    Inventors: Jeremy I. Levin, Aranapakam M. Venkatesan, Derek C. Cole, James M. Chen, Jamie M. Davis, George T. Grosu
  • Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors
    Patent number: 6340691
    Abstract: Compounds of the formula are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: January 22, 2002
    Assignee: American Cyanamid Company
    Inventors: Jeremy I. Levin, Aranapakam M. Venkatesan, Derek C. Cole, James M. Chen, Jamie M. Davis, George T. Grosu
  • Acetylenic &agr;-amino acid-based sulfonamide hydroxamic acid tace inhibitors
    Patent number: 6225311
    Abstract: Compounds of the formula: are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: May 1, 2001
    Assignee: American Cyanamid Company
    Inventors: Jeremy I. Levin, James M. Chen, Derek C. Cole, Mila T. Du, Leif M. Laakso