Patents by Inventor Derek Cecil Cole

Derek Cecil Cole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
    Patent number: 7022701
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: April 20, 2004
    Date of Patent: April 4, 2006
    Assignee: Wyeth
    Inventors: Derek Cecil Cole, Joseph Raymond Stock, William Joseph Lennox, Ping Zhou
  • (1-substituted-indol-3-yl) alkylidenehydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands
    Patent number: 6951881
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a disorder relating to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: October 4, 2005
    Assignee: Wyeth
    Inventors: Derek Cecil Cole, Michael Gerard Kelly, Byron Abel Bravo, Yvette Latko Palmer
  • Indolylalkylidenehydrazine-carboximidamide derivatives as 5-hydroxytryptamine-6 ligands
    Patent number: 6906095
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a disorder relating to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: June 14, 2005
    Assignee: Wyeth
    Inventors: Derek Cecil Cole, Michael Gerard Kelly, David Scott Nunn, Lynne Padilla Greenblatt
  • Heterocyclylindazole and -azaindazole compounds as 5-hydroxytryptamine-6 ligands
    Patent number: 6903112
    Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: October 23, 2003
    Date of Patent: June 7, 2005
    Assignee: Wyeth
    Inventors: Ping Zhou, Derek Cecil Cole, Michael Gerard Kelly, William Joseph Lennox
  • Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
    Publication number: 20040209867
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: April 20, 2004
    Publication date: October 21, 2004
    Applicant: Wyeth
    Inventors: Derek Cecil Cole, Joseph Raymond Stock, William Joseph Lennox, Ping Zhou
  • Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof
    Publication number: 20040198778
    Abstract: Compounds of Formula (I), 1
    Type: Application
    Filed: March 26, 2004
    Publication date: October 7, 2004
    Applicant: Wyeth
    Inventors: Anthony Frank Kreft, Lynn Resnick, Scott Christian Mayer, George Diamantidis, Derek Cecil Cole, Boyd Lynn Harrison, Minsheng Zhang, Molly Hoke, Tingzhong Wang, Rocco John Galante
  • Process for the synthesis of chirally pure beta-amino-alcohols
    Patent number: 6800764
    Abstract: A process is provided for preparing chirally pure S-enantiomers of &agr;-amino acids comprising the steps of: a) preparing an organometallic reagent from an alkyl halide of the formula (R)2CH(CH2)nCH2X; b) adding the organometallic reagent to carbon dioxide to afford a carboxylic acid; c) activating the carboxylic acid with an acid chloride, phosphorus trichloride, acid anhydride, or thionyl chloride in the presence of a tertiary amine base; d) reacting the product of step c) with an alkali metal salt of S-4-benzyl-2-oxazolidinone; e) treating the product of step d) with a strong non-nucleophilic base to form an enolate anion; f) trapping the enolate anion with 2,4,6-triisopropylbenzenesulfonyl azide to afford an oxazolidinone azide; g) hydrolyzing the oxazolidinone azide with an aqueous base to afford an &agr;-azido acid; h) reducing the &agr;-azido acid to the &agr;-amino acid; and i) recrystallizing the &agr;-amino acid to the chirally pure &agr;-amino acid.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: October 5, 2004
    Assignee: Wyeth
    Inventors: Anthony Frank Kreft, Madelene Miyoko Antane, Derek Cecil Cole, Dennis Martin Kubrak, Lynn Resnick, Joseph Raymond Stock, Zheng Wang
  • Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
    Patent number: 6800640
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: October 5, 2004
    Assignee: Wyeth
    Inventors: Ronald Charles Bernotas, Derek Cecil Cole, William Joseph Lennox
  • 1-Aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands
    Publication number: 20040192749
    Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: January 16, 2004
    Publication date: September 30, 2004
    Applicant: Wyeth
    Inventors: Michael Gerard Kelly, Derek Cecil Cole
  • Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
    Patent number: 6770642
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: August 3, 2004
    Assignee: Wyeth
    Inventors: Derek Cecil Cole, Joseph Raymond Stock, William Joseph Lennox, Ping Zhou
  • Heterocyclylindazole and -azaindazole compounds as 5-hydroxytryptamine-6 ligands
    Patent number: 6767912
    Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: July 27, 2004
    Assignee: Wyeth
    Inventors: Ping Zhou, Derek Cecil Cole, Michael Gerard Kelly, William Joseph Lennox
  • 1-Aryl-or 1-alkylsulfonyl-heterocyclybenzoles as 5-hydroxytryptamine-6 ligands
    Publication number: 20040132741
    Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: December 4, 2003
    Publication date: July 8, 2004
    Applicant: Wyeth
    Inventors: Michael Gerard Kelly, Derek Cecil Cole
  • Heterocyclylindazole and -azaindazole compounds as 5-hydroxytryptamine-6 ligands
    Publication number: 20040092526
    Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: October 23, 2003
    Publication date: May 13, 2004
    Applicant: Wyeth
    Inventors: Ping Zhou, Derek Cecil Cole, Michael Gerard Kelly, William Joseph Lennox
  • 1-aryl- or 1-alkylsulfony-heterocyclybenzazoles as 5-hydroxytryptamine-6 ligands
    Publication number: 20040087595
    Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: December 4, 2003
    Publication date: May 6, 2004
    Applicant: Wyeth
    Inventors: Michael Gerard Kelly, Derek Cecil Cole
  • Substituted phenylsulfonamide inhibitors of beta amyloid production
    Publication number: 20040006050
    Abstract: Compounds of Formula I, 1
    Type: Application
    Filed: June 9, 2003
    Publication date: January 8, 2004
    Applicants: Wyeth, ArQule Inc.
    Inventors: Anthony Frank Kreft, Derek Cecil Cole, Kevin Roger Woller, Joseph Raymond Stock, Kristina Martha Kutterer, Dennis Martin Kubrak, Charles William Mann, William Jay Moore, David Scott Casebier
  • Indolylalkylidenehydrazine-carboximidamide derivatives as 5-hydroxytryptamine-6 ligands
    Publication number: 20040002527
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a disorder relating to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: May 9, 2003
    Publication date: January 1, 2004
    Applicant: Wyeth
    Inventors: Derek Cecil Cole, Michael Gerard Kelly, David Scott Nunn, Lynne Padilla Greenblatt
  • (1-Substituted-indol-3-yl) alkylidenehydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands
    Publication number: 20030232843
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a disorder relating to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: May 9, 2003
    Publication date: December 18, 2003
    Applicant: Wyeth
    Inventors: Derek Cecil Cole, Michael Gerard Kelly, Byron Abel Bravo, Yvette Latko Palmer
  • Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
    Publication number: 20030171395
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: December 19, 2002
    Publication date: September 11, 2003
    Applicant: Wyeth
    Inventors: Ronald Charles Bernotas, Derek Cecil Cole, William Joseph Lennox
  • Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
    Publication number: 20030171353
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: December 19, 2002
    Publication date: September 11, 2003
    Applicant: Wyeth
    Inventors: Derek Cecil Cole, Joseph Raymond Stock, William Joseph Lennox, Ping Zhou
  • Process for the synthesis of chirally pure beta-amino-alcohols
    Publication number: 20030144531
    Abstract: A process is provided for preparing chirally pure S-enantiomers of &agr;-amino acids comprising the steps of: a) preparing an organometallic reagent from an alkyl halide of the formula (R)2CH(CH2)nCH2X; b) adding the organometallic reagent to carbon dioxide to afford a carboxylic acid; c) activating the carboxylic acid with an acid chloride, phosphorus trichloride, acid anhydride, or thionyl chloride in the presence of a tertiary amine base; d) reacting the product of step c) with an alkali metal salt of S-4-benzyl-2-oxazolidinone; e) treating the product of step d) with a strong non-nucleophilic base to form an enolate anion; f) trapping the enolate anion with 2,4,6-triisopropylbenzenesulfonyl azide to afford an oxazolidinone azide; g) hydrolyzing the oxazolidinone azide with an aqueous base to afford an &agr;-azido acid; h) reducing the &agr;-azido acid to the &agr;-amino acid; and i) recrystallizing the &agr;-amino acid to the chirally pure &agr;-amino acid.
    Type: Application
    Filed: November 26, 2002
    Publication date: July 31, 2003
    Applicant: Wyeth
    Inventors: Anthony Frank Kreft, Madelene Miyoko Antane, Derek Cecil Cole, Dennis Martin Kubrak, Lynn Resnick, Joseph Raymond Stock, Zheng Wang