Abstract: The present disclosure relates to transaminase polypeptides capable of aminating a dicarbonyl substrate, and polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides.

Abstract: The present disclosure describes a multi-function, integrated Super Beam assembly structure with integrated structural, cooling, and transverse elastic compliance functions; and Thermal Management Propagation (TMP) protection. The Super Beam assembly includes a pair of parallel face plates, coolant channel cover plates, and coolant channels that are defined by the face plate and the one or more coolant channel cover plates. The structural design of the cooling channels, and the corresponding air gaps formed in-between them, allows a transverse elastic compliance of the Super Beam assembly to be tuned to different amounts of elasticity. Top, bottom and/or end structural channels may be included. A pair of TMP suppression channels may be attached to the Super Beam assembly structure with an adhesive “thermal fuse” that preferentially melts and causes the pair of TMP suppression channels to detach from the Super Beam assembly during overheating in a TMP event.

Abstract: Lock assemblies for ladders and other rail assemblies are provided. In some embodiments, a ladder section includes a first rail and a second rail with openings extending therethrough. A lock assembly is disposed between the first rail and the second rail to selectively engage the opening in the first and second rails. The lock assembly includes a first rod and a second rod. The lock assembly also includes a first pusher that engages the first rod and a second pusher that engages the second rod. A first lever extends from an outer surface of the first pusher. A second lever extends from an outer surface of the second pusher to create a pinch grasp portion with the first lever. The lock assembly has a locked position that secures the ladder section and an unlocked position that allows the ladder section to be reconfigured with respect to another structure.

Abstract: A battery pack includes a first header having a first conduit and a second header having a second conduit. The battery pack also includes an energy storage system having energy storage cells arranged between the first header and the second header. A coolant plate assembly is arranged between the first header and the second header and abuts the plurality of energy storage cells. The coolant plate assembly includes a coolant channel having a first end fluidically connected to the first conduit, a second end fluidically connected to the second conduit, and an intermediate portion defining a flow path. The coolant plate assembly also includes a first planar section having a first surface facing the energy storage cells and a second surface having protrusions extending into the coolant channel.

Abstract: The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.

Abstract: Provided herein are radiopharmaceutical compositions and uses thereof. The radiopharmaceutical compositions can comprise one or more stabilizing agents, an aqueous vehicle, and a conjugate that comprises a targeting ligand and a radionuclide bound to a metal chelator. The targeting ligand can be a small molecule compound or a peptide such as a monocyclic peptide. The targeting ligand can be configured to bind with a tumor target. The stabilizing agent can comprise a radiolysis stabilizer, a free metal chelator, and/or a pH stabilizer. Further provided herein are methods of preparing the radiopharmaceutical compositions and methods of treating cancer by administering the described radiopharmaceutical compositions.

Abstract: An endoscope system is provided with a graphical orientation indicator. An endoscope includes a flexible tubular body with a steerable distal end having a camera. A controller for the endoscope presents a user interface that displays a view from the camera and a graphical orientation indicator visually representing an orientation of the distal end of the endoscope.

Abstract: A modular multi-cell rechargeable energy storage system (RESS) includes a RESS enclosure surrounded by an external environment and having an enclosure tray and an enclosure cover. The RESS also includes a plurality of battery cell blocks arranged in the RESS enclosure. Each battery cell block includes a cell case including a cell vent and at least one electrically insulated structural connector configured to link the cell case with an adjacent battery cell block. Each battery cell block also includes a thermal mitigation barrier (TMB) segment fixed to the cell case and configured to contact the adjacent battery cell block. Each battery cell block additionally includes a thermal insulator configured to line the cell vent. Furthermore, each battery cell block includes a bus bar segment configured to interconnect with a bus bar segment of the adjacent battery cell block.

Abstract: A system which provides closed loop insulin administration is disclosed. The system includes redundant glucose sensors which may be interleaved in order to provide monitoring when one of the glucose sensors is in a settling period. The system may include a disease management unit which includes both a glucose sensor and an insulin pump. A closed loop disease management system which bases insulin administration on accurate glucose measurements may improve a patient's quality of life.

Abstract: A video laryngoscope with blade identification is disclosed. The video laryngoscope may be capable of identifying a blade that has been coupled to the video laryngoscope. Identification of the blade may be based on an image from a camera of the video laryngoscope. The blade identification may be automatic. Blade identification may be performed via image recognition rules and/or machine learning (ML) models. Additionally, an image may be the only information used to determine blade identification. Based on the blade identification, various settings of the video laryngoscope may be adjusted (e.g., lighting or camera settings). Determined blade identification may be sent to a facility computer for maintaining patient records, procedure records, and/or inventory. Additionally, blade identification may be used in determining a video classification of intubation (VCI) score.

Abstract: A summary of a conversation may be generated using a neural network and a label space. Conversation turns of the conversation may be processed with a neural network, such as a classifier neural network, to compute label scores for two or more labels. The label scores for the conversation turns may be processed to compute tag scores for tags of the conversation turns. A subset of the tags may be selected using the tag scores where the selected tags represent aspects of the conversation. Text representations of the selected tags may be obtained, and the text representations may be used for generating the conversation summary.

Abstract: A method of forming source/drain features in a FinFET device includes providing a fin formed over a substrate and a gate structure formed over a fin, forming a recess in the fin adjacent to the gate structure, forming a first epitaxial layer in the recess, forming a second epitaxial layer over the first epitaxial layer, and forming a third epitaxial layer over the second epitaxial layer. The second epitaxial layer may be doped with a first element, while one or both of the first and the third epitaxial layer includes a second element different from the first element. One or both of the first and the third epitaxial layer may be formed by a plasma deposition process.

Abstract: A method of forming source/drain features in a FinFET device includes providing a fin formed over a substrate and a gate structure formed over a fin, forming a recess in the fin adjacent to the gate structure, forming a first epitaxial layer in the recess, forming a second epitaxial layer over the first epitaxial layer, and forming a third epitaxial layer over the second epitaxial layer. The second epitaxial layer may be doped with a first element, while one or both of the first and the third epitaxial layer includes a second element different from the first element. One or both of the first and the third epitaxial layer may be formed by a plasma deposition process.

Abstract: A method of treating endothelial dysfunction in a subject can include: identifying damage in an endothelial glycocalyx (EGX) of the subject, and administering to the subject a combination of a nitric oxide (NO) precursor and a hydrogen sulfide (H2S) precursor in an amount and at a frequency sufficient to stabilize and reverse damage in the EGX. A therapeutic composition for treating endothelial dysfunction can include a combination of a nitric oxide (NO) precursor and a hydrogen sulfide (H2S) precursor in an amount sufficient to sustain an increase of bioavailable NO for the treatment of endothelial dysfunction, and a pharmaceutically acceptable carrier.

Abstract: Disclosed herein are systems and methods for estimating an orbit of a satellite using only images captured by an onboard camera of the satellite. One of the disclosed methods includes: capturing a plurality of images using an onboard camera of the satellite; determining the trajectory, loop closure metrics, and the relative geographic position of the satellite using the plurality of images captured by the onboard camera; and estimating the orbit of the satellite based at least on the determined trajectory, loop closure metrics, and the relative geographic position of the satellite.

Abstract: Systems and methods are disclosed for measuring pulsed laser output. An example system comprises a laser configured to emit output in pulses; at least one sensor positioned to sense laser output and configured to convert that output into electrical signals; an edge detector configured to detect at least leading edges of a plurality of laser pulses; an analog to digital converter configured to convert electrical signals from a sensor into digital signals indicative of laser power output; and a controller; wherein, based on the detection of at least the leading edges of the laser pulses, the controller is configured to obtain samples of laser power output during the laser pulses. The system may refrain from sampling laser power output between laser pulses or may sample laser power output between laser pulses at a reduced sample rate. The system may use the samples of laser power output in a feedback loop to automatically adjust laser power.

Abstract: A method of forming source/drain features in a FinFET device includes providing a fin formed over a substrate and a gate structure formed over a fin, forming a recess in the fin adjacent to the gate structure, forming a first epitaxial layer in the recess, forming a second epitaxial layer over the first epitaxial layer, and forming a third epitaxial layer over the second epitaxial layer. The second epitaxial layer may be doped with a first element, while one or both of the first and the third epitaxial layer includes a second element different from the first element. One or both of the first and the third epitaxial layer may be formed by a plasma deposition process.

Abstract: A method of forming source/drain features in a FinFET device includes providing a fin formed over a substrate and a gate structure formed over a fin, forming a recess in the fin adjacent to the gate structure, forming a first epitaxial layer in the recess, forming a second epitaxial layer over the first epitaxial layer, and forming a third epitaxial layer over the second epitaxial layer. The second epitaxial layer may be doped with a first element, while one or both of the first and the third epitaxial layer includes a second element different from the first element. One or both of the first and the third epitaxial layer may be formed by a plasma deposition process.

Abstract: A method of forming source/drain features in a FinFET device includes providing a fin formed over a substrate and a gate structure formed over a fin, forming a recess in the fin adjacent to the gate structure, forming a first epitaxial layer in the recess, forming a second epitaxial layer over the first epitaxial layer, and forming a third epitaxial layer over the second epitaxial layer. The second epitaxial layer may be doped with a first element, while one or both of the first and the third epitaxial layer includes a second element different from the first element. One or both of the first and the third epitaxial layer may be formed by a plasma deposition process.