Abstract: Provided are an anti-microbial matrix and filtration systems containing the same. The matrix comprises a surface-modified inorganic component and a polymeric binder comprising particles having an irregular, convoluted surface. The surface-modified inorganic component comprises a reaction product of an anti-microbial component and an inorganic component. The anti-microbial component comprises a quaternary ammonium salt containing an epoxide group. A covalent bond is, for example, between the quaternary ammonium cation and a hydroxyl group of the inorganic component. The quaternary ammonium salt can be poly(methyldiallylamine epichlorohydrin). Further, the quaternary ammonium salt can have the formula according to I: (Formula I), wherein n is in the range of 5 to 24. The inorganic component can be diatomaceous earth. The polymeric binder can comprise ultra high molecular weight polyethylene (UHMW PE). Methods of making and using the same are also provided.

Abstract: Provided are an anti-microbial matrix and filtration systems containing the same. The matrix comprises a surface-modified inorganic component and a polymeric binder comprising particles having an irregular, convoluted surface. The surface-modified inorganic component comprises a reaction product of an anti-microbial component and an inorganic component. The anti-microbial component comprises a quaternary ammonium salt containing an epoxide group. A covalent bond is, for example, between the quaternary ammonium cation and a hydroxyl group of the inorganic component. The quaternary ammonium salt can be poly(methyldiallylamine epichlorohydrin). Further, the quaternary ammonium salt can have the formula according to I: (Formula I), wherein n is in the range of 5 to 24. The inorganic component can be diatomaceous earth. The polymeric binder can comprise ultra high molecular weight polyethylene (UHMW PE). Methods of making and using the same are also provided.

Abstract: Improved composite microarray slides for use in micro-analytical diagnostic applications are disclosed. Specifically, composite microarray slides useful for carrying a microarray of biological polymers on the surface thereof including composite microarray slides having a porous membrane formed by a phase inversion process effectively attached by covalent bonding through chemical agents that comprise anchor/linker moieties to a substrate that prepares the substrate to sufficiently bond to the porous membrane formed by a phase inversion process such that the combination produced thereby is useful in microarray applications and wherein the composite microarray slides are covalently bonded to a solid base member, such as, for example, a glass or Mylar microscope slide, such that the combination produced thereby is useful in microarray applications. Apparatus and methods for fabricating the composite microarray slides are also disclosed.

Abstract: Improved composite microarray slides for use in micro-analytical diagnostic applications are disclosed. Specifically, composite microarray slides useful for carrying a microarray of biological polymers on the surface thereof including composite microarray slides having a porous membrane formed by a phase inversion process effectively attached by covalent bonding through chemical agents that comprise anchor/linker moieties to a substrate that prepares the substrate to sufficiently bond to the porous membrane formed by a phase inversion process such that the combination produced thereby is useful in microarray applications and wherein the composite microarray slides are covalently bonded to a solid base member, such as, for example, a glass or Mylar microscope slide, such that the combination produced thereby is useful in microarray applications. Apparatus and methods for fabricating the composite microarray slides are also disclosed.

Abstract: Improved composite microarray slides for use in micro-analytical diagnostic applications are disclosed. Specifically, composite microarray slides useful for carrying a microarray of biological polymers on the surface thereof including composite microarray slides having a porous membrane formed by a phase inversion process effectively attached by covalent bonding through chemical agents that comprise anchor/linker moieties to a substrate that prepares the substrate to sufficiently bond to the porous membrane formed by a phase inversion process such that the combination produced thereby is useful in microarray applications and wherein the composite microarray slides are covalently bonded to a solid base member, such as, for example, a glass or Mylar microscope slide, such that the combination produced thereby is useful in microarray applications. Apparatus and methods for fabricating the composite microarray slides are also disclosed.