Patents by Inventor Derek Di Yang

Derek Di Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • JNK3 MODULATORS AND METHODS OF USE
    Publication number: 20120240247
    Abstract: The c-Jun NH2-terminal kinase (JNK) group of MAP kinases are activated by exposure of cells to environmental stress. The role of JNK in the brain was examined by targeted disruption of the gene that encodes the neuronal isoform JNK3. It was found that JNK3 is required for the normal response to seizure activity. Methods of screening for molecules and compounds that decrease JNK3 expression or activity are described. Such molecules or compounds are useful for treating disorders involving excitotoxicity such as seizure disorders, Alzheimer's disease, Huntington disease, Parkinson's disease, and ischaemia.
    Type: Application
    Filed: December 16, 2011
    Publication date: September 20, 2012
    Inventors: Roger J. Davis, Richard A. Flavell, Pasko Rakic, Alan J. Whitmarsh, Chia-Yi Kuan, Derek Di Yang
  • JNK3 modulators and methods of use
    Patent number: 6943000
    Abstract: The c-Jun NH2-terminal kinase (JNK) group of MAP kinases are activated by exposure of cells to environmental stress. The role of JNK in the brain was examined by targeted disruption of the gene that encodes the neuronal isoform JNK3. It was found that JNK3 is required for the normal response to seizure activity. Methods of screening for molecules and compounds that decrease JNK3 expression or activity are described. Such molecules or compounds are useful for treating disorders involving excitotoxicity such as seizure disorders, Alzheimer's disease, Huntington disease, Parkinson's disease, and ischaemia.
    Type: Grant
    Filed: October 2, 1998
    Date of Patent: September 13, 2005
    Assignees: University of Massachusetts, Yale University
    Inventors: Roger J. Davis, Richard A. Flavell, Pasko Rakic, Alan J. Whitmarsh, Chia-Yi Kuan, Derek Di Yang
  • Treating t-cell mediated diseases by modulating dr6 activity
    Publication number: 20040043022
    Abstract: Novel methods are provided for the treatment or prevention of T cell mediated conditions in a mammal that comprise administering to said mammal a therapeutically effective amount of a pharmaceutical composition comprising at least one DR6 agonist or DR6 antagonist.
    Type: Application
    Filed: October 16, 2002
    Publication date: March 4, 2004
    Inventors: Josef Georg Heuer, Jinqi Liu, Songqing Na, Ho Yeong Song, Derek Di Yang
  • JNK3 MODULATORS AND METHODS OF USE
    Publication number: 20030023990
    Abstract: The c-Jun NH2-terminal kinase (JNK) group of MAP kinases are activated by exposure of cells to environmental stress. The role of JNK in the brain was examined by targeted disruption of the gene that encodes the neuronal isoform JNK3. It was found that JNK3 is required for the normal response to seizure activity. Methods of screening for molecules and compounds that decrease JNK3 expression or activity are described. Such molecules or compounds are useful for treating disorders involving excitotoxicity such as seizure disorders, Alzheimer's disease, Huntington disease, Parkinson's disease, and ischaemia.
    Type: Application
    Filed: October 2, 1998
    Publication date: January 30, 2003
    Applicant: University of Massachusetts
    Inventors: ROGER J. DAVIS, RICHARD A. FLAVELL, PASKO RAKIC, ALAN J. WHITMARSH, CHIA-YI KUAN, DEREK DI YANG