Patents by Inventor Derek Horton
Derek Horton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210102274Abstract: An alloy having the formula Ti1-xMx. M is Co, Sn, Cr, or a combination. The value x is from 0.001 to 0.02. A method of combining titanium metal and a dopant metal to form the alloy.Type: ApplicationFiled: December 14, 2020Publication date: April 8, 2021Applicant: The Government of the United States of America, as represented by the Secretary of the NavyInventors: Steve Policastro, Derek Horton, Carlos Hangarter, James A. Wollmershauser, Rachel Anderson
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Publication number: 20180053316Abstract: A non-destructive method for assessing the “degree of sensitization” of ship structures formed from aluminum-magnesium marine service alloys. Features of the method include (1) selective etching of beta phase in a sensitized aluminum-magnesium alloy (2) metallographic recording of the etched surface; (3) image enhancement to produce high-contrast binary images of etched and unetched areas; (4) image analysis of the enhanced images using line segments along grain boundaries to provide statistical information about the grain boundary beta phase percentage and (5) calibration, whereby the grain boundary beta phase percentage is converted to an expression of the degree of sensitization in the sample.Type: ApplicationFiled: August 1, 2016Publication date: February 22, 2018Applicant: The Government of the United States of America, as represented by the Secretary of the NavyInventors: Ronald L. Holtz, Derek Horton
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Patent number: 9898832Abstract: A non-destructive method for assessing the “degree of sensitization” of ship structures formed from aluminum-magnesium marine service alloys. Features of the method include (1) selective etching of beta phase in a sensitized aluminum-magnesium alloy (2) metallographic recording of the etched surface; (3) image enhancement to produce high-contrast binary images of etched and unetched areas; (4) image analysis of the enhanced images using line segments along grain boundaries to provide statistical information about the grain boundary beta phase percentage and (5) calibration, whereby the grain boundary beta phase percentage is converted to an expression of the degree of sensitization in the sample.Type: GrantFiled: August 1, 2016Date of Patent: February 20, 2018Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Ronald L. Holtz, Derek Horton
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Patent number: 9701342Abstract: A suspension mount assembly for mounting a subframe to a frame of a vehicle having a frame rail is provided. The suspension mount assembly includes a cross member and a stay. The cross member is coupled to the frame rail and at least partially defines a recess. The subframe includes a distal end at least partially positioned within the recess at a mounting point defined along a central axis of the recess. The stay couples the cross member to the frame rail and retains the subframe at least partially positioned within the recess at the mounting point.Type: GrantFiled: March 31, 2015Date of Patent: July 11, 2017Assignee: HONDA MOTOR CO., LTD.Inventors: Adam Goellner, Derek Horton, Keith Malarik, Martyn Morrish, Charles Gagliano, Michael Gebrian, Aaron Wright, Paul Martino
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Publication number: 20170167034Abstract: An alloy having the formula Ti1-xMx. M is Co, Sn, Cr, or a combination. The value x is from 0.001 to 0.02. A method of combining titanium metal and a dopant metal to form the alloy.Type: ApplicationFiled: December 15, 2016Publication date: June 15, 2017Applicant: The Government of the United States of America, as represented by the Secretary of the NavyInventors: Steve Policastro, Derek Horton, Carlos Hangarter, James A. Wollmershauser, Rachel Anderson
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Publication number: 20160288834Abstract: A suspension mount assembly for mounting a subframe to a frame of a vehicle having a frame rail is provided. The suspension mount assembly includes a cross member and a stay. The cross member is coupled to the frame rail and at least partially defines a recess. The subframe includes a distal end at least partially positioned within the recess at a mounting point defined along a central axis of the recess. The stay couples the cross member to the frame rail and retains the subframe at least partially positioned within the recess at the mounting point.Type: ApplicationFiled: March 31, 2015Publication date: October 6, 2016Inventors: Adam Goellner, Derek Horton, Keith Malarik, Martyn Morrish, Charles Gagliano, Michael Gebrian, Aaron Wright, Paul Martino
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Publication number: 20160108504Abstract: A method for desensitizing an aluminum alloy is presented. A desired location on the surface of an aluminum alloy sample is exposed to a controlled pulsed electron beam. The pulsed electron beam heats a shallow layer of the metal alloy having a desired depth at the desired location on the surface of the sample to a temperature between a solvus temperature and an annealing temperature of the metal alloy to controllably reduce a degree of sensitization of the metal alloy sample at the desired location, an extent of a reduction in the degree of sensitization being controllable by varying at least one of a voltage, a current density, a pulse duration, a pulse frequency and a number of pulses of the electron beam.Type: ApplicationFiled: February 5, 2015Publication date: April 21, 2016Inventors: John D. Sethian, Matthew C. Myers, Mathew Wolford, Frank Hegeler, Ronald L. Holtz, Derek Horton, Alexis C. Lewis, Kathryn J. Wahl
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Patent number: 9315886Abstract: A method for desensitizing an aluminum alloy is presented. A desired location on the surface of an aluminum alloy sample is exposed to a controlled pulsed electron beam. The pulsed electron beam heats a shallow layer of the metal alloy having a desired depth at the desired location on the surface of the sample to a temperature between a solvus temperature and an annealing temperature of the metal alloy to controllably reduce a degree of sensitization of the metal alloy sample at the desired location, an extent of a reduction in the degree of sensitization being controllable by varying at least one of a voltage, a current density, a pulse duration, a pulse frequency and a number of pulses of the electron beam.Type: GrantFiled: February 5, 2015Date of Patent: April 19, 2016Assignee: The United States of America, as represented by the Secretary of the NavyInventors: John D. Sethian, Matthew C. Myers, Mathew Wolford, Frank Hegeler, Ronald L. Holtz, Derek Horton, Alexis C. Lewis, Kathryn J. Wahl
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Patent number: 4870058Abstract: Compounds of the formula (I) and pharmaceutical preparations containing the same are disclosed ##STR1## wherein R.sup.1 is --OOCR.sup.3 or --OOC(CH.sub.2).sub.n COOR.sup.4 ; R.sup.2 is hydrogen, hydroxy or methoxy; one of X and X' is a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine and the other is hydrogen; one of Y and Y' is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and acyloxy; one of Z and Z' is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and acyloxy; R.sup.3 is an alkyl group containing 1 to 8 carbon atoms; R.sup.4 is a hydrogen atom, a metal atom, or an alkyl group containing 1 to 4 carbon atoms; and n is an integer of 0 to 6. These compounds are active in the inhibition of malignant diseases.Type: GrantFiled: February 3, 1988Date of Patent: September 26, 1989Assignee: Ohio State University Research FoundationInventors: Derek Horton, Waldemar Priebe
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Patent number: 4772688Abstract: Compounds of the formula (I) and pharmaceutical preparations containing the same are disclosed ##STR1## wherein R.sup.1 is --OOCR.sup.3 or --OOC(CH.sub.2).sub.n COOR.sup.4 ; R.sup.2 is hydrogen, hydroxy or methoxy; one of X and X' is a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine and the other is hydrogen; one of Y and Y' is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and acyloxy; one of Z and Z' is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and acyloxy; R.sup.3 is an alkyl group containing 1 to 8 carbon atoms; R.sup.4 is a hydrogen atom, a metal atom, or an alkyl group containing 1 to 4 carbon atoms; and n is an integer of 0 to 6. These compounds are active in the inhibition of malignant diseases.Type: GrantFiled: April 23, 1987Date of Patent: September 20, 1988Assignee: Ohio State University Research FoundationInventors: Derek Horton, Waldemar Priebe, Richard L. Wolgemuth
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Patent number: 4663445Abstract: Anthracycline antibiotics represented by the formula (I) ##STR1## wherein R is hydrogen or hydroxyl, one of X and Y is fluorine and the other is hydrogen or both X and Y are fluorine, and S is a 2-halo sugar moiety; pharmaceutical preparations containing the same; and a method for inhibiting the growth of mammalian tumors are disclosed.Type: GrantFiled: March 20, 1985Date of Patent: May 5, 1987Assignee: The Ohio State Research FoundationInventors: John S. Swenton, Derek Horton, Waldemar Priebe, Gary W. Morrow
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Patent number: 4562177Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is a hydrogen atom or a hydroxyl group; R.sup.2 is a hydrogen atom or a hydroxyl or methoxyl group; X is a fluorine, chlorine, bromine or iodine atom; one of Y and Y' is a hydrogen atom and the other is a hydrogen atom or a hydroxyl or acyloxy group; R.sup.3 and R.sup.4 are each independently a hydrogen atom, an alkyl group, a halo- or phenyl-substituted alkyl group, an acyl group or a halo- or phenyl-substituted acyl group or R.sup.3 and R.sup.4 together form a polymethylene chain having 4 to 6 carbon atoms, are useful as anti-tumor agents, especially for treating leukemia; in particular these compounds exhibit high antileukemic activity against P388 murine leukemia.Type: GrantFiled: April 22, 1983Date of Patent: December 31, 1985Assignee: The Ohio State University Research FoundationInventors: Derek Horton, Waldemar A. Priebe
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Patent number: 4537882Abstract: Compounds of the formula (I), acid addition salts thereof, and pharmaceutical preparations containing the same are disclosed ##STR1## wherein R.sup.1 is hydroxy; one of X and X' is hydrogen and the other is a halogen atom selected from the group consisting of fluorine, chlorine, bromine, and iodine; one of Y and Y' is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and --OCOR; one of Z and Z' is hydrogen and the other is hydrogen, hydroxy or --OCOR; and R is a lower alkyl group.Type: GrantFiled: May 10, 1984Date of Patent: August 27, 1985Assignee: Ohio State UniversityInventors: Derek Horton, Waldemar Priebe
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Patent number: 4427664Abstract: The compounds are derived from aglycons which may be daunomycin, desmethoxy daunomycin, adriamycin and carminomycin. A preferred compound is ##STR1## (1) R'=H; R.sup.2 =OMe; X; Y (2) R'=OH; R.sup.2 =OMe; X; Y(3) R'=H; R.sup.2 =H; X; Y(4) R'=H; R.sup.2 =OH; X; YwhereX=I, Cl, Br, or F andY=OH or AcO (acetoxy)where Y is AcO or OH and R'=H and R.sup.2 =OMe.These compounds are effective showing high anti-leukemic activity against P388 murine leukemia.Type: GrantFiled: August 17, 1982Date of Patent: January 24, 1984Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Derek Horton, Waldemar Priebe
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Patent number: 4201773Abstract: A series of compounds showing high antileukemic activity against P388 murine leukemia and increased aqueous solubility due to substitution of --OH for the known --NH.sub.2 at the 3' position of the hexopyranose sugar, i.e., daunosamine.These compounds are coupled products of aglycon selected from daunomycinone, desmethoxy daunomycinone, adriamycinone and carminomycinone. These compounds are coupled at the 0-7 position of the aglycon with an .alpha.Type: GrantFiled: July 26, 1978Date of Patent: May 6, 1980Assignee: The United States of America as represented by the Department of Health, Education and WelfareInventors: Derek Horton, Wolfgang Weckerle, Ernst F. Fuchs, Tak M. Cheung, Beat Winter, Roderick J. Sorenson
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Patent number: 4024333Abstract: A method for synthesizing daunosamine hydrochloride from methyl .alpha.-D-mannopyranoside. The major features of the preparative route involve the formation of a 2-deoxy-3-keto intermediate, whose oxime is reduced with high stereoselectivity to the D-ribo-3-amino compound, followed by a stereospecific step late in the sequence to introduce the terminal C-methyl group with inversion at C-5, to generate the required L-lyxo stereochemistry. The synthesis procedure affords daunosamine hydrochloride in 40% overall yield, with no chromatographic procedures for isolation being required in any of the steps.Type: GrantFiled: June 22, 1976Date of Patent: May 17, 1977Assignee: The United States of America as represented by the Department of Health, Education and WelfareInventors: Derek Horton, Wolfgang F. Weckerle