Patents by Inventor Derek Horton

Derek Horton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210102274
    Abstract: An alloy having the formula Ti1-xMx. M is Co, Sn, Cr, or a combination. The value x is from 0.001 to 0.02. A method of combining titanium metal and a dopant metal to form the alloy.
    Type: Application
    Filed: December 14, 2020
    Publication date: April 8, 2021
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Steve Policastro, Derek Horton, Carlos Hangarter, James A. Wollmershauser, Rachel Anderson
  • Publication number: 20180053316
    Abstract: A non-destructive method for assessing the “degree of sensitization” of ship structures formed from aluminum-magnesium marine service alloys. Features of the method include (1) selective etching of beta phase in a sensitized aluminum-magnesium alloy (2) metallographic recording of the etched surface; (3) image enhancement to produce high-contrast binary images of etched and unetched areas; (4) image analysis of the enhanced images using line segments along grain boundaries to provide statistical information about the grain boundary beta phase percentage and (5) calibration, whereby the grain boundary beta phase percentage is converted to an expression of the degree of sensitization in the sample.
    Type: Application
    Filed: August 1, 2016
    Publication date: February 22, 2018
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Ronald L. Holtz, Derek Horton
  • Patent number: 9898832
    Abstract: A non-destructive method for assessing the “degree of sensitization” of ship structures formed from aluminum-magnesium marine service alloys. Features of the method include (1) selective etching of beta phase in a sensitized aluminum-magnesium alloy (2) metallographic recording of the etched surface; (3) image enhancement to produce high-contrast binary images of etched and unetched areas; (4) image analysis of the enhanced images using line segments along grain boundaries to provide statistical information about the grain boundary beta phase percentage and (5) calibration, whereby the grain boundary beta phase percentage is converted to an expression of the degree of sensitization in the sample.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: February 20, 2018
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Ronald L. Holtz, Derek Horton
  • Patent number: 9701342
    Abstract: A suspension mount assembly for mounting a subframe to a frame of a vehicle having a frame rail is provided. The suspension mount assembly includes a cross member and a stay. The cross member is coupled to the frame rail and at least partially defines a recess. The subframe includes a distal end at least partially positioned within the recess at a mounting point defined along a central axis of the recess. The stay couples the cross member to the frame rail and retains the subframe at least partially positioned within the recess at the mounting point.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: July 11, 2017
    Assignee: HONDA MOTOR CO., LTD.
    Inventors: Adam Goellner, Derek Horton, Keith Malarik, Martyn Morrish, Charles Gagliano, Michael Gebrian, Aaron Wright, Paul Martino
  • Publication number: 20170167034
    Abstract: An alloy having the formula Ti1-xMx. M is Co, Sn, Cr, or a combination. The value x is from 0.001 to 0.02. A method of combining titanium metal and a dopant metal to form the alloy.
    Type: Application
    Filed: December 15, 2016
    Publication date: June 15, 2017
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Steve Policastro, Derek Horton, Carlos Hangarter, James A. Wollmershauser, Rachel Anderson
  • Publication number: 20160288834
    Abstract: A suspension mount assembly for mounting a subframe to a frame of a vehicle having a frame rail is provided. The suspension mount assembly includes a cross member and a stay. The cross member is coupled to the frame rail and at least partially defines a recess. The subframe includes a distal end at least partially positioned within the recess at a mounting point defined along a central axis of the recess. The stay couples the cross member to the frame rail and retains the subframe at least partially positioned within the recess at the mounting point.
    Type: Application
    Filed: March 31, 2015
    Publication date: October 6, 2016
    Inventors: Adam Goellner, Derek Horton, Keith Malarik, Martyn Morrish, Charles Gagliano, Michael Gebrian, Aaron Wright, Paul Martino
  • Publication number: 20160108504
    Abstract: A method for desensitizing an aluminum alloy is presented. A desired location on the surface of an aluminum alloy sample is exposed to a controlled pulsed electron beam. The pulsed electron beam heats a shallow layer of the metal alloy having a desired depth at the desired location on the surface of the sample to a temperature between a solvus temperature and an annealing temperature of the metal alloy to controllably reduce a degree of sensitization of the metal alloy sample at the desired location, an extent of a reduction in the degree of sensitization being controllable by varying at least one of a voltage, a current density, a pulse duration, a pulse frequency and a number of pulses of the electron beam.
    Type: Application
    Filed: February 5, 2015
    Publication date: April 21, 2016
    Inventors: John D. Sethian, Matthew C. Myers, Mathew Wolford, Frank Hegeler, Ronald L. Holtz, Derek Horton, Alexis C. Lewis, Kathryn J. Wahl
  • Patent number: 9315886
    Abstract: A method for desensitizing an aluminum alloy is presented. A desired location on the surface of an aluminum alloy sample is exposed to a controlled pulsed electron beam. The pulsed electron beam heats a shallow layer of the metal alloy having a desired depth at the desired location on the surface of the sample to a temperature between a solvus temperature and an annealing temperature of the metal alloy to controllably reduce a degree of sensitization of the metal alloy sample at the desired location, an extent of a reduction in the degree of sensitization being controllable by varying at least one of a voltage, a current density, a pulse duration, a pulse frequency and a number of pulses of the electron beam.
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: April 19, 2016
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: John D. Sethian, Matthew C. Myers, Mathew Wolford, Frank Hegeler, Ronald L. Holtz, Derek Horton, Alexis C. Lewis, Kathryn J. Wahl
  • Patent number: 4870058
    Abstract: Compounds of the formula (I) and pharmaceutical preparations containing the same are disclosed ##STR1## wherein R.sup.1 is --OOCR.sup.3 or --OOC(CH.sub.2).sub.n COOR.sup.4 ; R.sup.2 is hydrogen, hydroxy or methoxy; one of X and X' is a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine and the other is hydrogen; one of Y and Y' is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and acyloxy; one of Z and Z' is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and acyloxy; R.sup.3 is an alkyl group containing 1 to 8 carbon atoms; R.sup.4 is a hydrogen atom, a metal atom, or an alkyl group containing 1 to 4 carbon atoms; and n is an integer of 0 to 6. These compounds are active in the inhibition of malignant diseases.
    Type: Grant
    Filed: February 3, 1988
    Date of Patent: September 26, 1989
    Assignee: Ohio State University Research Foundation
    Inventors: Derek Horton, Waldemar Priebe
  • Patent number: 4772688
    Abstract: Compounds of the formula (I) and pharmaceutical preparations containing the same are disclosed ##STR1## wherein R.sup.1 is --OOCR.sup.3 or --OOC(CH.sub.2).sub.n COOR.sup.4 ; R.sup.2 is hydrogen, hydroxy or methoxy; one of X and X' is a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine and the other is hydrogen; one of Y and Y' is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and acyloxy; one of Z and Z' is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and acyloxy; R.sup.3 is an alkyl group containing 1 to 8 carbon atoms; R.sup.4 is a hydrogen atom, a metal atom, or an alkyl group containing 1 to 4 carbon atoms; and n is an integer of 0 to 6. These compounds are active in the inhibition of malignant diseases.
    Type: Grant
    Filed: April 23, 1987
    Date of Patent: September 20, 1988
    Assignee: Ohio State University Research Foundation
    Inventors: Derek Horton, Waldemar Priebe, Richard L. Wolgemuth
  • Patent number: 4663445
    Abstract: Anthracycline antibiotics represented by the formula (I) ##STR1## wherein R is hydrogen or hydroxyl, one of X and Y is fluorine and the other is hydrogen or both X and Y are fluorine, and S is a 2-halo sugar moiety; pharmaceutical preparations containing the same; and a method for inhibiting the growth of mammalian tumors are disclosed.
    Type: Grant
    Filed: March 20, 1985
    Date of Patent: May 5, 1987
    Assignee: The Ohio State Research Foundation
    Inventors: John S. Swenton, Derek Horton, Waldemar Priebe, Gary W. Morrow
  • Patent number: 4562177
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is a hydrogen atom or a hydroxyl group; R.sup.2 is a hydrogen atom or a hydroxyl or methoxyl group; X is a fluorine, chlorine, bromine or iodine atom; one of Y and Y' is a hydrogen atom and the other is a hydrogen atom or a hydroxyl or acyloxy group; R.sup.3 and R.sup.4 are each independently a hydrogen atom, an alkyl group, a halo- or phenyl-substituted alkyl group, an acyl group or a halo- or phenyl-substituted acyl group or R.sup.3 and R.sup.4 together form a polymethylene chain having 4 to 6 carbon atoms, are useful as anti-tumor agents, especially for treating leukemia; in particular these compounds exhibit high antileukemic activity against P388 murine leukemia.
    Type: Grant
    Filed: April 22, 1983
    Date of Patent: December 31, 1985
    Assignee: The Ohio State University Research Foundation
    Inventors: Derek Horton, Waldemar A. Priebe
  • Patent number: 4537882
    Abstract: Compounds of the formula (I), acid addition salts thereof, and pharmaceutical preparations containing the same are disclosed ##STR1## wherein R.sup.1 is hydroxy; one of X and X' is hydrogen and the other is a halogen atom selected from the group consisting of fluorine, chlorine, bromine, and iodine; one of Y and Y' is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and --OCOR; one of Z and Z' is hydrogen and the other is hydrogen, hydroxy or --OCOR; and R is a lower alkyl group.
    Type: Grant
    Filed: May 10, 1984
    Date of Patent: August 27, 1985
    Assignee: Ohio State University
    Inventors: Derek Horton, Waldemar Priebe
  • Patent number: 4427664
    Abstract: The compounds are derived from aglycons which may be daunomycin, desmethoxy daunomycin, adriamycin and carminomycin. A preferred compound is ##STR1## (1) R'=H; R.sup.2 =OMe; X; Y (2) R'=OH; R.sup.2 =OMe; X; Y(3) R'=H; R.sup.2 =H; X; Y(4) R'=H; R.sup.2 =OH; X; YwhereX=I, Cl, Br, or F andY=OH or AcO (acetoxy)where Y is AcO or OH and R'=H and R.sup.2 =OMe.These compounds are effective showing high anti-leukemic activity against P388 murine leukemia.
    Type: Grant
    Filed: August 17, 1982
    Date of Patent: January 24, 1984
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Derek Horton, Waldemar Priebe
  • Patent number: 4201773
    Abstract: A series of compounds showing high antileukemic activity against P388 murine leukemia and increased aqueous solubility due to substitution of --OH for the known --NH.sub.2 at the 3' position of the hexopyranose sugar, i.e., daunosamine.These compounds are coupled products of aglycon selected from daunomycinone, desmethoxy daunomycinone, adriamycinone and carminomycinone. These compounds are coupled at the 0-7 position of the aglycon with an .alpha.
    Type: Grant
    Filed: July 26, 1978
    Date of Patent: May 6, 1980
    Assignee: The United States of America as represented by the Department of Health, Education and Welfare
    Inventors: Derek Horton, Wolfgang Weckerle, Ernst F. Fuchs, Tak M. Cheung, Beat Winter, Roderick J. Sorenson
  • Patent number: 4024333
    Abstract: A method for synthesizing daunosamine hydrochloride from methyl .alpha.-D-mannopyranoside. The major features of the preparative route involve the formation of a 2-deoxy-3-keto intermediate, whose oxime is reduced with high stereoselectivity to the D-ribo-3-amino compound, followed by a stereospecific step late in the sequence to introduce the terminal C-methyl group with inversion at C-5, to generate the required L-lyxo stereochemistry. The synthesis procedure affords daunosamine hydrochloride in 40% overall yield, with no chromatographic procedures for isolation being required in any of the steps.
    Type: Grant
    Filed: June 22, 1976
    Date of Patent: May 17, 1977
    Assignee: The United States of America as represented by the Department of Health, Education and Welfare
    Inventors: Derek Horton, Wolfgang F. Weckerle